scbmtБИОМЕДИЦИНАJournal Biomed2074-59822713-0428Scientific center of biomedical technologies of Federal Medical and Biological Agencyscbmt-101Research ArticleДОКЛИНИЧЕСКИЕ ИССЛЕДОВАНИЯNON-CLINICAL RESEARCHESВлияние нового производного диэтиламиноэтанола на выраженность неврологического дефицита у крыс после черепно-мозговой травмыThe influence of new diethylaminoethanol compound on the neurologic deficit in rats after traumatic brain injuryСысоевЮ. И.SysoevY. I.susoyev92@mail.ruОковитыйС. В.OkovityiS. V.noemail@neicon.ruУзуегбунамБ. ..UzuegbunamB. ..noemail@neicon.ruФГОУ ВО «Санкт-Петербургская государственная химико-фармацевтическая академия» Минздрава РоссииRussian Federation2018260220190295105Copyright © Сысоев Ю.И., Оковитый С.В., Узуегбунам Б..., 20192019Сысоев Ю.И., Оковитый С.В., Узуегбунам Б...Sysoev Y.I., Okovityi S.V., Uzuegbunam B...Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.scbmt.ru/jour/article/view/101

Оценено влияние нового производного диэтиламиноэтанола на выраженность неврологических нарушений у крыс после черепно-мозговой травмы (ЧМТ) на модели контролируемого кортикального ударного повреждения «Controlled cortical impact injury». Установлено, что повреждение зоны сенсомоторной коры у крыс вызывает стойкий неврологический дефицит, наиболее выраженный в первые сутки после операции, с постепенным улучшением состояния животных в течение последующих дней. Проведено сравнение нейропротекторного действия изучаемого соединения с другими средствами, используемыми при ЧМТ. Применение нового производного диэтиламиноэтанола у травмированных животных приводило к улучшению состояния моторной функции передней и задней конечностей, расположенных контрлатерально к месту повреждения, а также к увеличению показателей общей двигательной и поисково-исследовательской активности.

The influence of the new diethylaminoethanol derivative on the neurological deficit in rats after traumatic brain injury in the model «Controlled cortical impact injury» was evaluated. It was found, that damage of sensorimotor cortex cause the steady neurologic deficit in rats, which is mostly pronounced on the first day after the operation with the gradient improvement of condition of animals during the next days. Also, neuroprotective properties of the studying agent were compared with existing analogues. The usе of the new diethylaminoethanol compound in traumatized rats led to improvement of hindlimb and forelimb motor function, which are situated contralaterally to the damaged area of the brain. Also the overall movement activity and research-exploratory activity were normalized.

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CDPcholine treatment induces brain plasticity markers expression in experimental animal stroke. Neurochem. Int. 2012. Vol. 60. No. 3. Pp. 310-317.Gutierrez-Fernandez M., Rodriguez-Frutos B., Fuentes B., et al. CDPcholine treatment induces brain plasticity markers expression in experimental animal stroke. Neurochem. Int. 2012. Vol. 60. No. 3. Pp. 310-317.Hashimoto M., Kazui H., Matsumoto K., et al. Does donepezil treatment slow the progression of hippocampal atrophy in patients with Alzheimer’s disease. Am. J. Psychiatry. 2005. Vol. 162. No. 4. Pp. 676-682.Hashimoto M., Kazui H., Matsumoto K., et al. Does donepezil treatment slow the progression of hippocampal atrophy in patients with Alzheimer’s disease. Am. J. Psychiatry. 2005. Vol. 162. No. 4. Pp. 676-682.Isaev N.K., Novikova S.V., Stelmashook E.V., et al. Mitochondria-targeted plastoquinone antioxidant skqr1 decreases trauma-induced neurological deficit in rat. Biochemistry (Moscow). 2012. Vol. 77. No. 9. Pp. 996-999.Isaev N.K., Novikova S.V., Stelmashook E.V., et al. Mitochondria-targeted plastoquinone antioxidant skqr1 decreases trauma-induced neurological deficit in rat. Biochemistry (Moscow). 2012. Vol. 77. No. 9. Pp. 996-999.Janowsky D., Davis J., El-Yousef M., et al. A cholinergic-adrenergic hypothesis of mania and depression. Lancet. 1972. No. 7778II. Pp. 632-635.Janowsky D., Davis J., El-Yousef M., et al. A cholinergic-adrenergic hypothesis of mania and depression. Lancet. 1972. No. 7778II. Pp. 632-635.Kilgard M., Merzenich M. Cortical map reorganization enabled by nucleus basalis activity. Science. 1998. Vol. 279. No. 5357. Pp. 1714-1718.Kilgard M., Merzenich M. Cortical map reorganization enabled by nucleus basalis activity. Science. 1998. Vol. 279. No. 5357. Pp. 1714-1718.O’Neill M., Murray T., Lakics V., et al. The role of neuronal nicotinic acetylcholine receptors in acute and chronic neurodegeneration. Curr. drug targets CNS neurol. disord. 2002. Vol. 1. No. 4. Pp. 399-411.O’Neill M., Murray T., Lakics V., et al. The role of neuronal nicotinic acetylcholine receptors in acute and chronic neurodegeneration. Curr. drug targets CNS neurol. disord. 2002. Vol. 1. No. 4. Pp. 399-411.Paxinos G., Watson C. The rat brain in stereotaxic coordinates. 7th edition. Academic press. 2013. P. 12.Paxinos G., Watson C. The rat brain in stereotaxic coordinates. 7th edition. Academic press. 2013. P. 12.Warburton E., Koder T., Cho K., et al. Cholinergic neurotransmission is essential for perirhinal cortical plasticity and recognition memory. Neuron. 2003. Vol. 38. No. 6. Pp. 987-996.Warburton E., Koder T., Cho K., et al. Cholinergic neurotransmission is essential for perirhinal cortical plasticity and recognition memory. Neuron. 2003. Vol. 38. No. 6. Pp. 987-996.

The authors declare that there are no conflicts of interest present.