scbmtБИОМЕДИЦИНАJournal Biomed2074-59822713-0428Scientific center of biomedical technologies of Federal Medical and Biological Agencyscbmt-1038Research ArticleСтатьиКлассические и альтернативные модели в лекарственной токсикологииКаркищенкоН. Н.noemail@neicon.ruНаучный центр биомедицинских технологий РАМНRussian Federation20061302202014123Copyright © Каркищенко Н.Н., 20202020Каркищенко Н.Н.Каркищенко Н.Н.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.scbmt.ru/jour/article/view/1038

Даны генетически обусловленные и экспериментальные модели для оценки острой и хронической токсичности фармакологических веществ, общетоксического действия ксенобиотиков, специальных средств защиты. Приводятся стандартизованные и альтернативные модели оценки острой и хронической токсичности, альтернативные батареи тестов и основные стратегии токсикокинетики, токсикопротеомики, токсикогеномики, а также подходы к компьютерному моделированию токсичности.

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The authors declare that there are no conflicts of interest present.