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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">scbmt</journal-id><journal-title-group><journal-title xml:lang="ru">БИОМЕДИЦИНА</journal-title><trans-title-group xml:lang="en"><trans-title>Journal Biomed</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2074-5982</issn><issn pub-type="epub">2713-0428</issn><publisher><publisher-name>Scientific center of biomedical technologies of Federal Medical and Biological Agency</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">scbmt-107</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>МЕТОДЫ БИОМЕДИЦИНСКИХ ИССЛЕДОВАНИЙ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>METHODS OF BIOMEDICAL RESEARCHES</subject></subj-group></article-categories><title-group><article-title>Морфологическая характеристика мышц голени в условиях высокоскоростного дистракционого остеосинтеза в сочетании с внутрикостным титановым стержнем, напылённым гидроксиапатитом</article-title><trans-title-group xml:lang="en"><trans-title>Morphological characteristics of tibial muscles in the conditions of high rate distraction osteosynthesis in combination with itramedullary hydrohyapatite-coated titanium nail</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Попков</surname><given-names>А. В.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Филимонова</surname><given-names>Г. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Filimonova</surname><given-names>G. N.</given-names></name></name-alternatives><email xlink:type="simple">galnik.kurgan@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кононович</surname><given-names>Н. А.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Горбач</surname><given-names>Е. Н.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Попков</surname><given-names>Д. А.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">ФГБУ «Российский научный центр «Восстановительная травматология и ортопедия» им. акад. Г.А. Илизарова» Минздрава России<country>Россия</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>26</day><month>02</month><year>2019</year></pub-date><volume>0</volume><issue>3</issue><fpage>62</fpage><lpage>73</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Попков А.В., Филимонова Г.Н., Кононович Н.А., Горбач Е.Н., Попков Д.А., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Попков А.В., Филимонова Г.Н., Кононович Н.А., Горбач Е.Н., Попков Д.А.</copyright-holder><copyright-holder xml:lang="en">Попков А.В., Filimonova G.N., Кононович Н.А., Горбач Е.Н., Попков Д.А.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.scbmt.ru/jour/article/view/107">https://journal.scbmt.ru/jour/article/view/107</self-uri><abstract><p>Цель работы - сравнение морфофункциональных характеристик мышц голени в условиях чрескостного дистракционного остеосинтеза посредством скоростной высокодробной автодистракции и в комбинации с интрамедулярным армированием. Основные эксперименты выполнены на беспородных собаках обоего пола в возрасте скелетной зрелости, у которых осуществляли удлинение голени круглосуточным автодистрактором в темпе 3,0 мм в течение 10 суток. У животных группы № 1 шаг автодистрактора был 0,025 мм за 120 приёмов. Под общим наркозом осуществляли интрамедуллярное армирование большеберцовой кости спицей из титанового сплава (Ti6Al 4V) толщиной 1,8 мм с покрытием гидроксиапатитом по технологии микродугового оксидирования, осуществляли остеосинтез аппаратом Илизарова и поперечную остеотомию большеберцовой кости. В группе № 2 шаг автодистрактора был равен 0,017 мм за 180 приёмов, а период фиксации - 30 суток. По окончании дистракции и через 3 мес. после снятия аппарата исследовали переднюю большеберцовую мышцу. Животные группы № 1 активно использовали опытную конечность с первых дней дистракции, период фиксации был сокращён в 2 раза. Макропрепараты мышц животных группы № 1 фактически не различались на опытной и контралатеральной конечностях. Гистоструктура мышцы в обеих группах характеризовалась признаками активизации ангио- и миогистогенеза, но у собак в группе № 1 объёмная плотность микрососудов была выше в 3 раза в периоде удлинения. Сделан вывод о том, что метод высокоскоростной автодистракции конечности в сочетании с интрамедуллярным армированием титановой спицей с гидроксиапатитным напылением оказывает активирующее воздействие на ангио- и миогенез: гистоструктурные характеристики большеберцовой мышцы свидетельствуют о преобладании процессов репаративной регенерации по типу реституции. В результате сохраняется функциональная активность конечности с первых дней дистракции, а период фиксации сокращается вдвое.</p></abstract><trans-abstract xml:lang="en"><p>The purpose of this work is to compare of the morphofunctional characteristics of the lower leg muscles in conditions of transosseous distraction osteosynthesis by high-rate and high-fractional automated destraction and in combination with intraosseous reinforcement with a titanium. The main experiments were performed on mongrel dogs of both sexes at the age of skeletal maturity, lengthening of the tibia was performed with a daily autodistractor at a rate of 3.0 mm for 10 days. In the animals of group No. 1, the autodistractor step was 0.025 mm at 120 times. At the general anesthesia, intramedullary reinforcement of the tibia was a 1.8- mm titanium (Ti6Al 4V) coated with hydroxyapatite by microarc oxidation technology. Next, osteosynthesis with an Ilizarov apparatus and transverse osteotomy of the tibia were produced. In the group No. 2, the autodistractor step was 0.017 mm at 180 times, тhe fixation period was 30 days. At the end of the distraction and 3 months after the removal of the apparatus, the tibial muscles were examined. Animals of the group No. 1 actively used the limb from the first days of distraction. The period of fixation decreased twice. Macro-preparations of muscles of dogs in group No. 1 did not significantly differ in the experimental and contralateral limbs. The histostructure of the muscles in both groups was characterized by signs of activation of angiogenesis and myogistogenesis, but in the group No. 1 the volume density of microvessels was 3 times higher in the period of elongation. It was concluded that the method of high-speed limb auto-extrusion in combination with intramedullary reinforcement of titanium wire with hydroxyapatite spraying has an activating effect on angiogenesis and myogenesis. The histostructural characteristics of the tibial muscle testify to the predominance of the processes of reparative regeneration by the type of restitution. As a result, the functional activity of the limb remains from the first days of distraction, the period of fixation is reduced by 2 times.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>мышцы</kwd><kwd>автодистракция</kwd><kwd>интрамедулярное армирование</kwd><kwd>гидроксиапатитное покрытие</kwd></kwd-group><kwd-group xml:lang="en"><kwd>muscles</kwd><kwd>automated distraction</kwd><kwd>intramedular reinforcement</kwd><kwd>hydroxyapatite coating</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Гаркавенко Ю.Е., Поздеев А.П. Ошибки и осложнения при удлинении нижних конечностей у детей // Вестник гильдии протезистов-ортопедов. - 2004. - № 5. - С. 61-63.</mixed-citation><mixed-citation xml:lang="en">Гаркавенко Ю.Е., Поздеев А.П. 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