scbmtБИОМЕДИЦИНАJournal Biomed2074-59822713-0428Scientific center of biomedical technologies of Federal Medical and Biological Agency10.33647/2074-5982-16-3-106-110scbmt-1208Research ArticleСПЕЦИАЛЬНЫЕ ВОПРОСЫ ФАРМАКОТОКСИКОЛОГИИSPECIAL PHARMACOTOXICOLOGY ISSUESМоделирование ингаляционных отравлений сернистым ипритомModelling of Inhalation Poisoning with Sulphur Mustard GasБулкаК. А.BulkaK. A.

Булка Кирилл Александрович

194044, Санкт-Петербург, ул. Лебедева, д. 6

Kirill A. Bulka

194044, Saint Petersburg, Lebedeva str., 6

visoret@list.ruКузьминА. А.KuzminA. A.

Кузьмин Андрей Александрович, д.м.н.

195043, Санкт-Петербург, ул. Лесопарковая, д. 4

Andrey A. Kuzmin, Dr. Sci. (Med.)

195043, Saint Petersburg, Lesoparkovaya str., 4

gniiivm_2@mil.comСидоровС. П.SidorovS. P.

Сидоров Сергей Павлович, к.м.н.

195043, Санкт-Петербург, ул. Лесопарковая, д. 4

Sergey P. Sidorov, Cand. Sci. (Med.)

195043, Saint Petersburg, Lesoparkovaya str., 4

gniiivm_2@mil.comЧубарьО. В.ChubarO. V.

Чубарь Олег Владимирович, д.м.н.

195043, Санкт-Петербург, ул. Лесопарковая, д. 4

Oleg V. Chubar, Dr. Sci. (Med.)

195043, Saint Petersburg, Lesoparkovaya str., 4

gniiivm_2@mil.comХалимовЮ. Ш.KhalimovYu. Sh.

Халимов Юрий Шавкатович, д.м.н.

194044, Санкт-Петербург, ул. Лебедева, д. 6

Yuriy Sh. Khalimov, Dr. Sci. (Med.)

194044, Saint Petersburg, Lebedeva str., 6

yushkha@gmail.comФГБВОУ ВПО «Военно-медицинская академия им. С.М. Кирова» Минобороны РоссииРоссияS.M. Kirov Military Medical Academy of the Ministry of Defence of RussiaRussian FederationФГБУ «Государственный научно-исследовательский испытательный институт военной медицины» Минобороны РоссииРоссияState Scientific Research Test Institute of Military Medicine of the Ministry of Defence of RussiaRussian Federation202003092020163106110Copyright © Булка К.А., Кузьмин А.А., Сидоров С.П., Чубарь О.В., Халимов Ю.Ш., 20202020Булка К.А., Кузьмин А.А., Сидоров С.П., Чубарь О.В., Халимов Ю.Ш.Bulka K.A., Kuzmin A.A., Sidorov S.P., Chubar O.V., Khalimov Y.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.scbmt.ru/jour/article/view/1208

В настоящей работе представлено описание существующих на сегодняшний день экспериментальных моделей ингаляционного поражения сернистым ипритом, а также анализ их достоинств и недостатков с точки зрения возможности использования при разработке медицинских средств защиты. В качестве одного из перспективных подходов предложено использование микроспрееров, сочетающих в себе техническую возможность перевода иприта из жидкого состояния в аэрозольное, эргономическую простоту и безопасность для экспериментатора.

The present work describes the currently existing experimental models of sulphur mustard gas inhalation injury. These models were analysed in terms of their suitability for the development of medical protective equipment. It is proposed to use micro-sprayers, which provide the possibility of transferring mustard gas from a liquid state to an aerosol form while exhibiting an increased ergonomic simplicity and safety.

ипритаэрозольмикроспреерmustard gasaerosolmicro-sprayerReferencesКорнякова В.В., Ашвиц И.В., Муратов В.А. К вопросу о механизме действия иприта. Здоровье и образование в XXI веке. 2017;19(8):26–33.Kornyakova V.V., Ashwitz I.V., Muratov V.A. K voprosu o mekhanizme deystviya iprita [To the question of mustard gas action mechanism]. Zdorov’ye i obrazovaniye v XXI veke [Health and Education in XXI Century]. 2017;19(8):26–33. (In Russian).Супотницкий М.В., Шило Н.И., Ковтун В.А. Химическое оружие в Ирано-Иракской войне 1980–1988 годов. 1. Подготовка Ирака к химической войне. Вестник войск РХБ защиты. 2019;3(1):40–64.Supotnitskiy M.V., Shilo N.I., Kovtun V.I. Chimicheskoe oruzhie v Irano-Irakskoj vojne 1980–1988 godov. 1. Podgotovka Irana k himicheskoy vojne [Chemical weapon in Iran-Iraq war 1980–1988. 1. Irans preparing to Chemical war]. Vestnik vojsk RHB zashchity [Radiation, Chemical and Biological Protection Corps Messenger]. 2019;3(1):40–64. (In Russian).Супотницкий М.В., Шило Н.И., Ковтун В.А. Химическое оружие в Ирано-Иракской войне 19801988 годов. 2. Применение химического оружия в боевых действиях. Вестник войск РХБ защиты. 2019;3(2):150–174.Supotnitskiy M.V., Shilo N.I., Kovtun V.I. Chimicheskoe oruzhie v Irano-Irakskoj vojne 1980–1988 godov. 2. Primeneniye khimicheskogo oruzhiya v boyevikh deystviyakh [Chemical weapon in Iran-Iraq war 1980–1988. 2. The usage of chemical weapon in battle action]. Vestnik vojsk RHB zashchity [Radiation, Chemical and Biological Protection Corps Messenger]. 2019;3(2):150–174. (In Russian).Супотницкий М.В., Шило Н.И., Ковтун В.А. Химическое оружие в Ирано-Иракской войне 1980–1988 годов. 3. Медицинские последствия химической войны. Вестник войск РХБ защиты. 2019;3(3):255–288.Supotnitskiy M.V., Shilo N.I., Kovtun V.I. Chimicheskoe oruzhie v Irano-Irakskoj vojne 1980–1988 godov. 2. Primeneniye khimicheskogo oruzhiya v boyevikh deystviyakh. [Chemical weapon in Iran-Iraq war 1980–1988. 3. The usage of chemical weapon in battle action]. Vestnik vojsk RHB zashchity [Radiation, Chemical and Biological Protection Corps Messenger]. 2019;3(3):255–288. (In Russian).Anderson D.R., Yourick J.J., Moeller R.B., Petrali J.P., Young D., Byers S.L. Evaluation of protease inhibitors and an antioxidant for treatment of sulfur mustard-induced toxic lung injury. Toxicology. 2009;263:41–46.Anderson D.R., Yourick J.J., Moeller R.B., Petrali J.P., Young D., Byers S.L. Evaluation of protease inhibitors and an antioxidant for treatment of sulfur mustard-induced toxic lung injury. Toxicology. 2009;263:41–46.Boskabady M.H., Vahedi N., Amery S., Khakzad M.R. The effect of Nigella sativa alone, and in combination with dexamethasone, on tracheal muscle responsiveness and lung inflammation in sulfur mustard exposed guinea pigs. J. Ethnopharmacol. 2011;137(2):1028–1034.Boskabady M.H., Vahedi N., Amery S., Khakzad M.R. The effect of Nigella sativa alone, and in combination with dexamethasone, on tracheal muscle responsiveness and lung inflammation in sulfur mustard exposed guinea pigs. J. Ethnopharmacol. 2011;137(2):1028–1034.Calvet J.H., Coste A., Levame M., Harf A., MacquinMavier I., Escudier E. Airway epithelial damage and release of inflammatory mediators in human lung parenchyma after sulfur mustard exposure. Hum. Exp. Toxicol. 1999;18:77–81.Calvet J.H., Coste A., Levame M., Harf A., MacquinMavier I., Escudier E. Airway epithelial damage and release of inflammatory mediators in human lung parenchyma after sulfur mustard exposure. Hum. Exp. Toxicol. 1999;18:77–81.Gholamnezhad Z., Boskabady M.H., Amery S., Vahedi N., Tabatabaei A., Boskabady M., et al. The effect of vitamin E on tracheal responsiveness and lung inflammation in sulfur mustard exposed guinea pigs. Inhal. Toxicol. 2011;23:157–165.Gholamnezhad Z., Boskabady M.H., Amery S., Vahedi N., Tabatabaei A., Boskabady M., et al. The effect of vitamin E on tracheal responsiveness and lung inflammation in sulfur mustard exposed guinea pigs. Inhal. Toxicol. 2011;23:157–165.Jiang Y.Y., Li Z., Yu D., Xie J., Zhu X., Zhong Y. Changes in inflammatory factors and protein expression in sulfur mustard (1LD50)-induced acute pulmonary injury in rats. Int. Immunopharmacol. 2018;61:338–345.Jiang Y.Y., Li Z., Yu D., Xie J., Zhu X., Zhong Y. Changes in inflammatory factors and protein expression in sulfur mustard (1LD50)-induced acute pulmonary injury in rats. Int. Immunopharmacol. 2018;61:338–345.Kilic E. Acute intensive care unit management of mustard gas victims: the Turkish experience. Cutaneous and Ocular Toxicology. 2018;37(4):332–337.Kilic E. Acute intensive care unit management of mustard gas victims: the Turkish experience. Cutaneous and Ocular Toxicology. 2018;37(4):332–337.Mariappan N., Husain M., Zafar I., Singh V., Smithson K.G., Crowe D.R., et al. Extracellular nucleic acid scavenging rescues rats from sulfur mustard analog-induced lung injury and mortality. Archives of Toxicology. 2020;94(4):1321–1334.Mariappan N., Husain M., Zafar I., Singh V., Smithson K.G., Crowe D.R., et al. Extracellular nucleic acid scavenging rescues rats from sulfur mustard analog-induced lung injury and mortality. Archives of Toxicology. 2020;94(4):1321–1334.McClintock S.D., Hoesel L.M., Das S.K., Till G.O., Neff T., Kunkel R.G., et al. Attenuation of half sulfur mustard gas-induced acute lung injury in rats. J. Appl. Toxicol. 2006;26:126–131.McClintock S.D., Hoesel L.M., Das S.K., Till G.O., Neff T., Kunkel R.G., et al. Attenuation of half sulfur mustard gas-induced acute lung injury in rats. J. Appl. Toxicol. 2006;26:126–131.Sermet S. Victims of chemical terrorism, a family of four who were exposed to sulfur mustard. Toxicology Letters. 2018;294:1–22.Sermet S. Victims of chemical terrorism, a family of four who were exposed to sulfur mustard. Toxicology Letters. 2018;294:1–22.Veress L.A., O’Neill H.C., Hendry-Hofer T.B., Loader J.E., Rancourt R.C., White C.W. Airway obstruction due to bronchial vascular injury after sulfur mustard analog inhalation. Am. J. Respir. Crit. Care Med. 2010;182:1352–1361.Veress L.A., O’Neill H.C., Hendry-Hofer T.B., Loader J.E., Rancourt R.C., White C.W. Airway obstruction due to bronchial vascular injury after sulfur mustard analog inhalation. Am. J. Respir. Crit. Care Med. 2010;182:1352–1361.Xiaoji Z., Xiao M., Rui X., Haibo C., Chao Z., Chengjin L., et al. Mechanism underlying acute lung injury due to sulfur mustard exposure in rats. Toxicology and Industrial Health. 2016;32(8):1345–1357.Xiaoji Z., Xiao M., Rui X., Haibo C., Chao Z., Chengjin L., et al. Mechanism underlying acute lung injury due to sulfur mustard exposure in rats. Toxicology and Industrial Health. 2016;32(8):1345–1357.Yu D., Bei Y., Li Y., Han W., Zhong Y., Liu F., et al. In vitro the differences of inflammatory and oxidative reactions due to sulfur mustard induced acute pulmonary injury underlying intraperitoneal injection and intratracheal instillation in rats. Int. Immunopharmacol. 2017;47:78–87.Yu D., Bei Y., Li Y., Han W., Zhong Y., Liu F., et al. In vitro the differences of inflammatory and oxidative reactions due to sulfur mustard induced acute pulmonary injury underlying intraperitoneal injection and intratracheal instillation in rats. Int. Immunopharmacol. 2017;47:78–87.

The authors declare that there are no conflicts of interest present.