scbmtБИОМЕДИЦИНАJournal Biomed2074-59822713-0428Scientific center of biomedical technologies of Federal Medical and Biological Agencyscbmt-121Research ArticleИНФОРМАЦИОННЫЕ МАТЕРИАЛЫИммуногенные липопептидыImmunogenic lipopeptidesБелявцевА. Н.BelyavtsevA. N.belyavcev@mirea.ruНиколаеваЛ. И.NikolaevaL. I.noemail@neicon.ruШастинаН. С.ShastinaN. S.noemail@neicon.ruКуприяновВ. В.KoupriyanovV. V.noemail@neicon.ruФГБУ «Национальный исследовательский центр эпидемиологии и микробиологии имени почетного академика Н.Ф. Гамалеи» Минздрава России; ФГБОУ ВО «МИРЭА - Российский технологический университет»Russian FederationФГБУ «Национальный исследовательский центр эпидемиологии и микробиологии имени почетного академика Н.Ф. Гамалеи» Минздрава РоссииRussian FederationФГБОУ ВО «МИРЭА - Российский технологический университет»Russian FederationФГУ «Федеральный исследовательский центр «Фундаментальные основы биотехнологии» РАН»Russian Federation201826022019048895Copyright © Белявцев А.Н., Николаева Л.И., Шастина Н.С., Куприянов В.В., 20192019Белявцев А.Н., Николаева Л.И., Шастина Н.С., Куприянов В.В.Belyavtsev A.N., Nikolaeva L.I., Shastina N.S., Koupriyanov V.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.scbmt.ru/jour/article/view/121

Липопротеины и липопептиды представляют собой амфифильные соединения. Липопептиды и их синтетические аналоги обладают биологической активностью in vivo : иммуномодулирующей, противоопухолевой, противовирусной, фунгицидной, бактерицидной и адъювантной. Синтетические липопептиды (как аналоги бактериальных) обладают адъювантными свойствами, могут вызывать продукцию цитокинов Th1- и Th2-профиля, усиливать функциональную активность CD8+ T-клеток памяти и CD4+ T-клеточную пролиферацию, что послужило причиной их использования при конструировании вакцинных препаратов.

Lipoproteins and lipopeptides are amphiphilic compounds. Lipopeptides and their synthetic analogs possess biological activities in vivo , so as immunomodulating, antitumor, antiviral, fungicidal, bactericidal and adjuvant activities. Synthetic lipopeptides (as bacterial analogs) have adjuvant properties, they can cause the production of Th1- and Th2-cytokines, enhance the functional activity of CD8+ T-memory cells and CD4+ T-cell proliferation, which has led to using lipopeptides in the design of vaccine preparations.

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The authors declare that there are no conflicts of interest present.