scbmtБИОМЕДИЦИНАJournal Biomed2074-59822713-0428Scientific center of biomedical technologies of Federal Medical and Biological Agency10.33647/2074-5982-17-1-70-81scbmt-1253Research ArticleРЕЛЕВАНТНОЕ И АЛЬТЕРНАТИВНОЕ БИОМОДЕЛИРОВАНИЕRELEVANT AND ALTERNATIVE BIOMODELLINGГенетические и индуцированные модели животных с дегенерацией сетчаткиConflict of interest: the authors declare no conflict of interest.БайгильдинС. С.BaygildinS. S.

Байгильдин Самат Сагадатович

450106, Уфа, ул. Степана Кувыкина, 94; 450076, Уфа, ул. Заки Валиди, 32

Samat S. Baygildin

450106, Ufa, Kuvykina Street, 94; 450076, Ufa, Zaki Validi Street, 32

baigildin.samat@yandex.ruМусинаЛ. А.MusinaL. A.

Мусина Ляля Ахияровна - доктор биологических наук.

450076, Уфа, ул. Заки Валиди, 32

Lyalya A. Musina - Dr. Sci. (Biol.)

420075, Ufa, Zorge Street, 67/1

morphoplant@mail.ruХисматуллинаЗ. Р.KhismatullinaZ. R.

Хисматуллина Зухра Рашидовна - доктор биологических наук, профессор.

450076, Уфа, ул. Заки Валиди, 32

Zukhra R. Khismatullina - Dr. Sci. (Biol.), Prof.

450076, Ufa, Zaki Validi Street, 32

hismatullinazr@mail.ruФБУН Уфимский НИИ медицины труда и экологии человека; ФГБОУ ВО Башкирский государственный университетРоссияUfa Research Institute of Occupational Health and Human Ecology; Bashkir State UniversityRussian FederationФГБОУ ВО Башкирский государственный университетРоссияRussian Eye and Plastic Surgery Centre of the Ministry of Health care of RussiaRussian FederationФГБОУ ВО Башкирский государственный университетРоссияBashkir State UniversityRussian Federation2021250220211717081Copyright © Байгильдин С.С., Мусина Л.А., Хисматуллина З.Р., 20212021Байгильдин С.С., Мусина Л.А., Хисматуллина З.Р.Baygildin S.S., Musina L.A., Khismatullina Z.R.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.scbmt.ru/jour/article/view/1253

Дегенерации сетчатки представляют собой обширную и гетерогенную группу заболеваний (дистрофий) сетчатки, которые приводят к прогрессирующей потере зрения. Одновременно с развитием новых методов экспериментальной терапии (генной и клеточной терапии, регенеративной офтальмохирургии) возрастает потребность в экспериментальных моделях. В обзоре рассматриваются различные животные модели дегенеративных заболеваний сетчатки глаза человека. Индуцированные и генетические экспериментальные модели имеют свои преимущества и недостатки, освещающиеся в обзоре. Адекватный выбор экспериментальной модели может способствовать патогенетическому подходу лечения заболеваний сетчатки.

Retinal degenerations comprise a large heterogeneous class of diseases (dystrophies) of retina leading to a progressive vision loss. The emergence of new experimental therapies (gene and cell therapy, regenerative ophthalmic surgery) generates a demand for new experimental models. The review tackles various animal models of human retinal degenerative diseases. Pros and contras of induced and genetic experimental models are highlighted. An adequate experimental model choice may condition a pathogenetic approach to retinal disease therapy.

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The authors declare that there are no conflicts of interest present.