scbmtБИОМЕДИЦИНАJournal Biomed2074-59822713-0428Scientific center of biomedical technologies of Federal Medical and Biological Agency10.33647/2074-5982-17-2-22-34scbmt-1268Research ArticleМЕТОДЫ БИОМЕДИЦИНСКИХ ИССЛЕДОВАНИЙMETHODS OF BIOMEDICAL RESEARCHESМодель «выученной беспомощности» у крыс: возможности и ограничения при оценке депрессивно-подобного состояния и эффектов антидепрессантов.The “Learned Helplessness” Model in Rats: Possibilities and Limitations in Assessing a Depressive-Like State and Effects of AntidepressantsВальдманЕ. А.ValdmanE. A.

Вальдман Елена Артуровна, д.м.н., проф

125315, Российская Федерация, Москва, Балтийская ул., 8

Elena A. Valdman, Dr. Sci. (Med.), Prof.

125315,  Moscow, Baltiyskaya Str., 8

evaldman@mail.ruКрайневаВ. А.KrainevaV. A.

Крайнева Валентина Александровна, к.б.н.

125315, Российская Федерация, Москва, Балтийская ул., 8

Valentina A. Kraineva, Cand. Sci. (Biol.)

125315,  Moscow, Baltiyskaya Str., 8

krayneva@academpharm.ruКотельниковаС. О.KotelnikovaS. O.

Котельникова Светлана Олеговна, к.б.н.

125315, Российская Федерация, Москва, Балтийская ул., 8

Svetlana O. Kotelnikova, Cand. Sci. (Biol.)

125315,  Moscow, Baltiyskaya Str., 8

ailantha@mail.ruCадовскийМ. С.SadovskyM. S.

Садовский Максим Сергеевич

125315, Российская Федерация, Москва, Балтийская ул., 8

Maksim S. Sadovsky

125315,  Moscow, Baltiyskaya Str., 8

sadowskymaxim@yandex.ruФГБНУ «Научно-исследовательский институт фармакологии имени В.В. Закусова»РоссияZakusov Institute of PharmacologyRussian Federation2021250620211722234Copyright © Вальдман Е.А., Крайнева В.А., Котельникова С.О., Cадовский М.С., 20212021Вальдман Е.А., Крайнева В.А., Котельникова С.О., Cадовский М.С.Valdman E.A., Kraineva V.A., Kotelnikova S.O., Sadovsky M.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.scbmt.ru/jour/article/view/1268

Модель «выученной беспомощности» (ВБ) у крыс широко используется в наборе тестов для оценки депрессивно-подобного состояния и эффектов антидепрессантов. Модель оценивается как достаточно валидная, но имеющая ограничения по воспроизводимости. В обзоре представлены возможности использования модели для оценки симптомов депрессивно-подобного состояния и отдельных звеньев патогенеза депрессии, эффектов антидепрессантов. Описаны факторы, влияющие на воспроизводимость модели ВБ, наиболее важным из которых является различная чувствительность животных к стрессу. Приведены различные протоколы формирования и тестирования ВБ, используемые в разных исследовательских коллективах. С учетом большого количества вариантов протоколов и получаемых результатов, сравнительный анализ которых затруднен, необходима стандартизация модели ВБ в условиях каждой конкретной лаборатории. Модель ВБ целесообразно использовать в доклинических исследованиях потенциальных препаратов с антидепрессивной активностью.

The “learned helplessness” (LH) model in rats is widely used in a battery of tests to assess depression-like behaviour and the effects of antidepressants. The model is considered to be suffi ciently valid, though having some limitations with reproducibility. This review discusses the possibilities of using the model for assessing the symptoms of a depressive-like state and the pathogenesis of depression, as well as the effects of antidepressants. The factors affecting the reproducibility of the LH model are described, the most important of which is the different sensitivity of animals to stress. Several protocols for the induction and testing of LH, which are used by different research teams, are presented. Due to the diffi culty of comparing the results obtained using different LH protocols, LH models should be standardized for use in individual laboratories. LH models are worth using in preclinical studies of potential drugs exhibiting antidepressant activity.

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The authors declare that there are no conflicts of interest present.