References

scbmt

БИОМЕДИЦИНА

Journal Biomed

2074-59822713-0428

Scientific center of biomedical technologies of Federal Medical and Biological Agency

10.33647/2074-5982-17-2-88-99

scbmt-1275

Research Article

ДОКЛИНИЧЕСКИЕ ИССЛЕДОВАНИЯ В БИОМЕДИЦИНЕ

NON-CLINICAL RESEARCH IN BIOMEDICINE

Механизмы цитотоксического действия оловоорганических соединений

Mechanisms of the Cytotoxic Action of Organotin Compounds

Милаева

Е. Р.

Milaeva

E. R.

Милаева Елена Рудольфовна, д.х.н., проф.

119991, Москва, ул. Ленинские горы, 1, стр. 3

Elena R. Milaeva, Dr. Sci. (Chem.), Prof.

119991, Moscow, Leninskie gory Str., 1, building 3

Додохова

М. А.

Dodokhova

M. A.

Додохова Маргарита Авдеевна*, к.м.н., доц.

344022, Ростов-на-Дону, Нахичеванский пер., 29

Margarita A. Dodokhova, Cand. Sci. (Med.), Assoc. Prof.

344022, Rostov-on-Don, Nakhichevansky Lane, 29

dodohova@mail.ru

Шпаковский

Д. Б.

Shpakovsky

D. B.

Шпаковский Дмитрий Борисович, к.х.н.

119991, Москва, ул. Ленинские горы, 1, стр. 3

Dmitry B. Shpakovsky, Cand. Sci. (Chem.)

119991, Moscow, Leninskie gory Str., 1, building 3

Антоненко

Т. А.

Antonenko

T. A.

Антоненко Таисия Алексеевна, к.х.н.

119991, Москва, ул. Ленинские горы, 1, стр. 3

Taisiya A. Antonenko, Cand. Sci. (Chem.)

119991, Moscow, Leninskie gory Str., 1, building 3

Сафроненко

А. В.

Safronenko

A. V.

Сафроненко Андрей Владимирович, д.м.н., доц.

344022, Ростов-на-Дону, Нахичеванский пер., 29

Andrey V. Safronenko, Dr. Sci. (Med.), Assoc. Prof.

344022, Rostov-on-Don, Nakhichevansky Lane, 29

Котиева

И. М.

Kotieva

I. M.

Котиева Инга Мовлиевна, д.м.н., доц.

344022, Ростов-на-Дону, Нахичеванский пер., 29

Inga M. Kotieva, Dr. Sci. (Med.), Assoc. Prof.

344022, Rostov-on-Don, Nakhichevansky Lane, 29

Комарова

Е. Ф.

Komarova

E. F.

Комарова Екатерина Федоровна, д.б.н., проф., проф. РАН

344022, Ростов-на-Дону, Нахичеванский пер., 29

Ekaterina F. Komarova, Dr. Sci. (Biol.), Prof., Prof. of RAS

344022, Rostov-on-Don, Nakhichevansky Lane, 29

Ганцгорн

Е. В.

Gantsgorn

E. V.

Ганцгорн Елена Владимировна, к.м.н.

344022, Ростов-на-Дону, Нахичеванский пер., 29

Elena V. Gantsgorn, Cand. Sci. (Med.)

344022, Rostov-on-Don, Nakhichevansky Lane, 29

Алхусейн-Кулягинова

М. С.

Alkhuseyn-Kulyaginova

M. S.

Алхусейн-Кулягинова Маргарита Стефановна

344022, Ростов-на-Дону, Нахичеванский пер., 29

Margarita S. Alkhuseyn-Kulyaginova

344022, Rostov-on-Don, Nakhichevansky Lane, 29

ФГБОУ ВО «Московский государственный университет имени М.В. Ломоносова»РоссияLomonosov Moscow State UniversityRussian Federation

ФГБОУ ВО «Ростовский государственный медицинский университет» Минздрава РоссииРоссияRostov State Medical University of the Ministry of Health care of RussiaRussian Federation

2021

26062021

1728899

2021

Милаева Е.Р., Додохова М.А., Шпаковский Д.Б., Антоненко Т.А., Сафроненко А.В., Котиева И.М., Комарова Е.Ф., Ганцгорн Е.В., Алхусейн-Кулягинова М.С.

Milaeva E.R., Dodokhova M.A., Shpakovsky D.B., Antonenko T.A., Safronenko A.V., Kotieva I.M., Komarova E.F., Gantsgorn E.V., Alkhuseyn-Kulyaginova M.S.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://journal.scbmt.ru/jour/article/view/1275

В обзоре проанализированы данные, представленные в доступной нам медицинской и научной литературе, посвященные доклиническому изучению in vitro цитотоксических свойств оловоорганических соединений (ООС), а также основных механизмов их действия. Последние, в частности, заключаются во взаимодействии со свободными SH группами белков, инициировании окислительного стресса, связывании с ДНК, взаимодействии с рецепторами, а также активированием апоптоза за счет повышения экспрессии каспаз, проапоптотических белков и уменьшением антиапоптотического белка. В зависимости от донорного лиганда ООС проявляют специфическую цитотоксичность по отношению к опухолевой клеточной линии. Высокий цитотоксический потенциал ООС указывает на целесообразность их дальнейшего изучения in vivo и разработки в качестве кандидатов для создания лекарственных средств для противоопухолевой и антиметастатической терапии.

This review analyzed the literature data on the in vitro preclinical study of the cytotoxic properties of organotin compounds, as well as the main mechanisms of their action. The latter consist in interacting with SH groups of proteins, initiating oxidative stress, binding to DNA, interacting with receptors, as well as activate apoptosis by increasing the expression of caspases, proapoptotic proteins, and decreasing antiapoptotic proteins. Organotin compounds, depending on the donor ligand, exhibit specifi c cytotoxicity towards certain tumor cell lines. The high cytotoxic potential indicates the possibility of further development in vivo and research of organotin compounds as candidates for the creation of drugs for anticancer and antimetastatic therapy.

оловоорганические соединенияцитотоксичностьмеханизм противоопухолевого действиядоклинические исследования in vitro

organotin compoundscytotoxicitymechanism of antitumor actionin vitro preclinical studies

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The authors declare that there are no conflicts of interest present.