scbmtБИОМЕДИЦИНАJournal Biomed2074-59822713-0428Scientific center of biomedical technologies of Federal Medical and Biological Agency10.33647/2713-0428-17-3E-42-47scbmt-1310Research ArticleМЕТОДЫ И ТЕХНОЛОГИИ БИОМЕДИЦИНСКИХ ИССЛЕДОВАНИЙMETHODS AND TECHNOLOGIES OF BIOMEDICAL RESEARCHУльтразвуковая оценка распределения трикальцийфосфатного наполнителя по объему набухших пористых матриксов на основе хитозана для биомедицинского примененияUltrasonic assessment of the distribution of tricalcium phosphate filler over the volume of swollen porous matrices based on chitosan for biomedical applicationsКуликоваО. Р.KulikovaO. R.

119334, Москва, ул. Косыгина, 4

119334, Moscow, Kosygina Str., 4

olga.kulikova.2012@list.ruХрамцоваЕ. А.KhramtsovaE. A.

к.б.н.,

119334, Москва, ул. Косыгина, 4

Cand. Sci. (Biol.),

119334, Moscow, Kosygina Str., 4

alyonushk@gmail.comАнтиповаК. Г.AntipovaK. G.

123182, Москва, пл. Академика Курчатова, 1

123098, Moscow, Akademika Kurchatova Square, 1

kris444ti@yandex.ruПацаевТ. Д.PatsaevT. D.

123182, Москва, пл. Академика Курчатова, 1

123098, Moscow, Akademika Kurchatova Square, 1

МороковЕ. С.MorokovE. S.

к.ф.-м.н., 

119334, Москва, ул. Косыгина, 4

Cand. Sci. (Phys.-Math.),

119334, Moscow, Kosygina Str., 4

es_morokov@yahoo.comЛуканинаК. И.LukaninaK. I.

к.т.н., 

123182, Москва, пл. Академика Курчатова, 1

Cand. Sci. (Tech.),

123098, Moscow, Akademika Kurchatova Square, 1

lukanina_ki@nrcki.ruЛевинВ. М.LevinV. M.

к.ф.-м.н., 

119334, Москва, ул. Косыгина, 4

Cand. Sci. (Phys.-Math.), 

119334, Moscow, Kosygina Str., 4

levin1943@gmail.comГригорьевТ. Е.GrigorievT. E.

к.ф.-м.н.,

123182, Москва, пл. Академика Курчатова, 1

Cand. Sci. (Phys.-Math.),

123098, Moscow, Akademika Kurchatova Square, 1

grigoriev@nrcki.ruФГБУН Институт биохимической физики им. Н.М. Эмануэля РАНРоссияEmanuel Institute of Biochemical Physics of the Russian Academy of SciencesRussian FederationНациональный исследовательский центр «Курчатовский институт»РоссияNational Research Center “Kurchatov Institute”Russian Federation202122102021173E4247Copyright © Куликова О.Р., Храмцова Е.А., Антипова К.Г., Пацаев Т.Д., Мороков Е.С., Луканина К.И., Левин В.М., Григорьев Т.Е., 20212021Куликова О.Р., Храмцова Е.А., Антипова К.Г., Пацаев Т.Д., Мороков Е.С., Луканина К.И., Левин В.М., Григорьев Т.Е.Kulikova O.R., Khramtsova E.A., Antipova K.G., Patsaev T.D., Morokov E.S., Lukanina K.I., Levin V.M., Grigoriev T.E.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.scbmt.ru/jour/article/view/1310

Регенеративная медицина — быстро развивающаяся междисциплинарная область. Основной интерес представляют новые материалы и механизмы их взаимодействия с живым организмом. Методы исследования изучаемых объектов должны обеспечивать как объёмную визуализацию, так и предоставлять оценку количественных характеристик неинвазивно. Перспективными для этих целей являются методы, основанные на применении ультразвука и отображающие вариации упругих свойств образцов. 

Regenerative medicine is a rapidly developing interdisciplinary field of science. Of primary interest are new materials and mechanisms of their interaction with living organisms. Investigation methods should provide 3D visualization and analysis of quantitative characteristics, while having no effect on the objects under study. For these purposes, methods based on ultrasound and those displaying variations in the elastic properties of samples are promising. 

пористый матриксхитозанкомпозитакустическая микроскопияporous matrixchitosancompositeacoustic microscopyПористые матриксы на основе хитозана разработаны в рамках ВНИР НИЦ «Курчатовский институт», ультразвуковые исследование проведены при поддержке гранта РФФИ № 20-33-70095.ReferencesGrigoriev T.E., Zagoskin Y.D., Belousov S.I., et al. Influence of molecular characteristics of chitosan on properties of in situ formed scaffolds. BioNanoSci. 2017;7:492–495. DOI: 10.1007/S12668-017-0411-5.Grigoriev T.E., Zagoskin Y.D., Belousov S.I., et al. Influence of molecular characteristics of chitosan on properties of in situ formed scaffolds. BioNanoSci. 2017;7:492–495. DOI: 10.1007/S12668-017-0411-5.Gudur M., Rao R.R., Hsiao Y.S., Peterson A.W., Deng C.X., Stegemann J.P. Noninvasive, quantitative, spatiotemporal characterization of mineralization in three-dimensional collagen hydrogels using high-resolution spectral ultrasound imaging. Tissue engineering. 2012;18(12):935–946. DOI: 10.1089/ten. 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The authors declare that there are no conflicts of interest present.