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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">scbmt</journal-id><journal-title-group><journal-title xml:lang="ru">БИОМЕДИЦИНА</journal-title><trans-title-group xml:lang="en"><trans-title>Journal Biomed</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2074-5982</issn><issn pub-type="epub">2713-0428</issn><publisher><publisher-name>Scientific center of biomedical technologies of Federal Medical and Biological Agency</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.33647/2713-0428-17-3E-99-105</article-id><article-id custom-type="elpub" pub-id-type="custom">scbmt-1320</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>БИОРЕГУЛЯТОРЫ В МЕДИЦИНСКИХ ТЕХНОЛОГИЯХ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>BIOREGULATORS IN MEDICAL TECHNOLOGIES</subject></subj-group></article-categories><title-group><article-title>Направленная регуляция микробиома человека: вклад в решение демографической проблемы в России</article-title><trans-title-group xml:lang="en"><trans-title>Directed regulation of the human microbiome: contribution to the solution of the demographic problem in Russia</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Абрамов</surname><given-names>В. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Abramov</surname><given-names>V. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p> д.б.н., проф.,</p><p>142380, Московская обл., Чеховский р-н, п. Любучаны, ул. Научная, 1</p></bio><bio xml:lang="en"><p>Dr. Sci. (Biol.), Prof.,</p><p>142380, Moscow Region, Chekhov District, Lyubuchany, Nauchnaya Str., 1</p></bio><email xlink:type="simple">slavab2017@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Косарев</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kosarev</surname><given-names>I. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.б.н., </p><p>142380, Московская обл., Чеховский р-н, п. Любучаны, ул. Научная, 1</p></bio><bio xml:lang="en"><p>Cand. Sci. (Biol.),</p><p>142380, Moscow Region, Chekhov District, Lyubuchany, Nauchnaya Str., 1</p></bio><email xlink:type="simple">kosarev-52@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Припутневич</surname><given-names>Т. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Priputnevich</surname><given-names>T. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., проф., </p><p>117997, Москва, ул. Академика Опарина, 4</p></bio><bio xml:lang="en"><p>Dr. Sci. (Med.), Prof.,</p><p>117997, Moscow, Akademika Oparina Str., 4</p></bio><email xlink:type="simple">priput1@gmail.com</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хлебников</surname><given-names>В. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Khlebnikov</surname><given-names>V. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.б.н., проф.,</p><p>142380, Московская обл., Чеховский р-н, п. Любучаны, ул. Научная, 1</p></bio><bio xml:lang="en"><p>Dr. Sci. (Biol.), Prof.,</p><p>142380, Moscow Region, Chekhov District, Lyubuchany, Nauchnaya Str., 1</p></bio><email xlink:type="simple">vkhleb@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Василенко</surname><given-names>Р. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Vasilenko</surname><given-names>R. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.б.н., </p><p>142380, Московская обл., Чеховский р-н, п. Любучаны, ул. Научная, 1</p></bio><bio xml:lang="en"><p>Cand. Sci. (Biol.), </p><p>142380, Moscow Region, Chekhov District, Lyubuchany, Nauchnaya Str., 1</p></bio><email xlink:type="simple">slavab2017@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пчелинцев</surname><given-names>С. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Pchelintsev</surname><given-names>S. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., проф.,</p><p>142380, Московская обл., Чеховский р-н, п. Любучаны, ул. Научная, 1</p></bio><bio xml:lang="en"><p>Dr. Sci. (Med.), Prof.,</p><p>142380, Moscow Region, Chekhov District, Lyubuchany, Nauchnaya Str., 1</p></bio><email xlink:type="simple">serg.pch@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Каркищенко</surname><given-names>В. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Karkischenko</surname><given-names>V. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p> д.м.н.,</p><p>143442, Московская обл., Красногорский р-н, п. Светлые горы, 1</p></bio><bio xml:lang="en"><p>Dr. Sci. (Med.), Prof., </p><p>143442, Moscow Region, Krasnogorsk District, Svetlye Gory Village, 1</p></bio><email xlink:type="simple">scbmt@yandex.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мачулин</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Machulin</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.б.н., </p><p>142290, Московская обл., г. Пущино, просп. Науки, 3</p></bio><bio xml:lang="en"><p>Cand. Sci. (Biol.),</p><p>142290, Moscow Region, Pushchino, Science Avenue, 3</p></bio><email xlink:type="simple">and.machul@gmail.com</email><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Абашина</surname><given-names>Т. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Abashina</surname><given-names>T. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.б.н., </p><p>142290, Московская обл., г. Пущино, просп. Науки, 3</p></bio><bio xml:lang="en"><p>Cand. Sci. (Biol.),</p><p>142290, Moscow Region, Pushchino, Science Avenue, 3</p></bio><email xlink:type="simple">tnabashina@gmail.com</email><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Самойленко</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Samoilenko</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p> к.б.н.,</p><p>142290, Московская обл., г. Пущино, просп. Науки, 3</p></bio><bio xml:lang="en"><p>Cand. Sci. (Biol.),</p><p>142290, Moscow Region, Pushchino, Science Avenue, 3</p></bio><email xlink:type="simple">samva@rambler.ru</email><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гасанов</surname><given-names>М. Т.</given-names></name><name name-style="western" xml:lang="en"><surname>Gasanov</surname><given-names>M. T.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н., доц.,</p><p>143442, Московская обл., Красногорский р-н, п. Светлые горы, 1</p></bio><bio xml:lang="en"><p>Cand. Sci. (Med.), Assoc. Prof., </p><p>143442, Moscow Region, Krasnogorsk District, Svetlye Gory Village, 1</p></bio><email xlink:type="simple">m.gasanov@scbmt.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Уверский</surname><given-names>В. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Uversky</surname><given-names>V. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.ф.-м.н., проф., </p><p>33620, Флорида, Тампа, просп. E. Фаулер, 4202</p></bio><bio xml:lang="en"><p>Dr. Sci. (Phys.-Math.), Prof.,</p><p>33620, Florida, Tampa, 4202 E. Fowler Avenue</p></bio><email xlink:type="simple">vuversky@usf.edu</email><xref ref-type="aff" rid="aff-5"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Карлышев</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Karlyshev</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.б.н., проф., </p><p>KT1 1LQ, Лондон, Суррей, Кингстон-апон-Темс, ул. Хайстрит, 53-57, Ривер Хаус</p></bio><bio xml:lang="en"><p>Cand. Sci. (Biol.), Prof.,</p><p>KT1 1LQ, London, Surrey, Kingston upon Thames, 53-57 High Str., River House</p></bio><email xlink:type="simple">a.karlyshev@kingston.ac.uk</email><xref ref-type="aff" rid="aff-6"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">ОАО «Институт инженерной иммунологии»<country>Россия</country></aff><aff xml:lang="en">Institute of Immunological Engineering<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">ФГБУ «Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии им. В.И. Кулакова» Минздрава России<country>Россия</country></aff><aff xml:lang="en">National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov of the Ministry of Health Care of Russia<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru">ФГБУН «Научный центр биомедицинских технологий ФМБА России»<country>Россия</country></aff><aff xml:lang="en">Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru">ФГБУН «Федеральный исследовательский центр «Пущинский научный центр биологических исследований РАН»<country>Россия</country></aff><aff xml:lang="en">Federal Research Center “Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences”<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-5"><aff xml:lang="ru">Университет Южной Флориды<country>Соединённые Штаты Америки</country></aff><aff xml:lang="en">University of South Florida<country>United States</country></aff></aff-alternatives><aff-alternatives id="aff-6"><aff xml:lang="ru">Кингстонский университет<country>Россия</country></aff><aff xml:lang="en">Kingston University London<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>24</day><month>10</month><year>2021</year></pub-date><volume>17</volume><issue>3E</issue><fpage>99</fpage><lpage>105</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Абрамов В.М., Косарев И.В., Припутневич Т.В., Хлебников В.С., Василенко Р.Н., Пчелинцев С.Ю., Каркищенко В.Н., Мачулин А.В., Абашина Т.Н., Самойленко В.А., Гасанов М.Т., Уверский В.Н., Карлышев А.В., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Абрамов В.М., Косарев И.В., Припутневич Т.В., Хлебников В.С., Василенко Р.Н., Пчелинцев С.Ю., Каркищенко В.Н., Мачулин А.В., Абашина Т.Н., Самойленко В.А., Гасанов М.Т., Уверский В.Н., Карлышев А.В.</copyright-holder><copyright-holder xml:lang="en">Abramov V.M., Kosarev I.V., Priputnevich T.V., Khlebnikov V.S., Vasilenko R.N., Pchelintsev S.Y., Karkischenko V.N., Machulin A.V., Abashina T.N., Samoilenko V.A., Gasanov M.T., Uversky V.N., Karlyshev A.V.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.scbmt.ru/jour/article/view/1320">https://journal.scbmt.ru/jour/article/view/1320</self-uri><abstract><p>Для решения возникшей в России демографической проблемы требуются комплексные многосторонние подходы, направленные на повышение рождаемости и снижение детской и взрослой смертности. Одним из подходов для решения этой проблемы является направленная регуляция микробиома человека. </p></abstract><trans-abstract xml:lang="en"><p>In order to solve the demographic problem that has arisen in Russia, comprehensive multilateral approaches are required, aimed at increasing the birth rate and reducing child and adult mortality. One approach to solve this problem is directed regulation of the human microbiome. </p></trans-abstract><kwd-group xml:lang="en"><kwd>demographic problem</kwd><kwd>directed regulation of the microbiome</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Ардатская М.Д. Масляная кислота и инулин в клинической практике: теоретические аспекты и возможности клинического применения. М.: Форте принт, 2014:64.</mixed-citation><mixed-citation xml:lang="en">Ardatskaya M.D. Maslyanaya kislota i inulin v klinicheskoy praktike: teoreticheskie aspekty i vozmozhnosti klinicheskogo primeneniya [Butyric acid and inulin in clinical practice: theoretical aspects and possibilities of clinical use]. Moscow: Forte print Publ., 2014:64. (In Russian).</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Бойцов С., Баланова Ю.А., Шальнова С.А. и др. Артериальная гипертония среди лиц 25–64 лет: распространённость, осведомлённость, лечение и контроль. По материалам исследования ЭССЕ. Кардиоваскулярная терапия и профилактика. 2014;13(4):4–14. DOI: 10.15829/1728-8800-2014-4-4-142.</mixed-citation><mixed-citation xml:lang="en">Boytsov S.A., Balanova Yu.A., Shalnova S.A., et al. Arterial’naja gipertonija sredi lic 25–64 let: rasprostranjonnost’, osvedomljonnost’, lechenie i kontrol’. Po materi alam issledovanija ESSE [Arterial hypertension among individuals of 25–64 years old: prevalence, awareness, treatment and control. By the data from ECCD]. Kardiovaskulyarnaya terapiya i profilaktika [Cardiovascular Therapy and Prevention]. 2014;13(4):4–14. (In Russian). DOI: 10.15829/1728-8800-2014-4-4-142.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Arumugam M., Raes J., Pelletier E., et al. Enterotypes of the human gut microbiome. Nature. 2011;473(7346):174–180. DOI: 10.1038/nature09944.</mixed-citation><mixed-citation xml:lang="en">Arumugam M., Raes J., Pelletier E., et al. Enterotypes of the human gut microbiome. Nature. 2011;473(7346):174–180. DOI: 10.1038/nature09944.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Cani P., Delzenne N. The role of the gut microbiota in energy metabolism and metabolic disease. Curr. Pharm. Des. 2009;15(13):1546–1558. DOI: 10.2174/138161209788168164.</mixed-citation><mixed-citation xml:lang="en">Cani P., Delzenne N. The role of the gut microbiota in energy metabolism and metabolic disease. Curr. Pharm. Des. 2009;15(13):1546–1558. DOI: 10.2174/138161209788168164.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Franceschi C., Garagnani P., Vitale G., Capri M., Salvioli S. Inflammaging and ‘Garb-aging’. Trends Endocrinol. Metab. 2017;28(3):199–212. DOI: 10.1016/j.tem.2016.09.005.</mixed-citation><mixed-citation xml:lang="en">Franceschi C., Garagnani P., Vitale G., Capri M., Salvioli S. Inflammaging and ‘Garb-aging’. Trends Endocrinol. Metab. 2017;28(3):199–212. DOI: 10.1016/j.tem.2016.09.005.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Kim J., Jun J.M., Kim M.K., Kwon O., Cho B. Lactobacillus gasseri BNR17 supplementation reduces the visceral fat accumulation and waist circumference in obese adults: A randomized, double-blind, placebo-controlled trial. J. Med. Food. 2018;21(5):454– 461. DOI: 10.1089/jmf.2017.3937.</mixed-citation><mixed-citation xml:lang="en">Kim J., Jun J.M., Kim M.K., Kwon O., Cho B. Lactobacillus gasseri BNR17 supplementation reduces the visceral fat accumulation and waist circumference in obese adults: A randomized, double-blind, placebo-controlled trial. J. Med. Food. 2018;21(5):454– 461. DOI: 10.1089/jmf.2017.3937.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Lee S., Bose S., Seo J., et al. The effects of co-administration of probiotics with herbal medicine on obesity, metabolic endotoxemia and dysbiosis: A randomized double-blind controlled clinical trial. Clin. Nutr. 2014;33(6):973–981. DOI: 10.1016/j.clnu.2013.12.006.</mixed-citation><mixed-citation xml:lang="en">Lee S., Bose S., Seo J., et al. The effects of co-administration of probiotics with herbal medicine on obesity, metabolic endotoxemia and dysbiosis: A randomized double-blind controlled clinical trial. Clin. Nutr. 2014;33(6):973–981. DOI: 10.1016/j.clnu.2013.12.006.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Lew S., Hor Y., Jaafar M., et al. Lactobacilli modulated AMPK activity and prevented telomere shortening in ageing rats. Benef. Microbes. 2019;10(8):883–892. DOI: 10.3920/BM2019.0058.</mixed-citation><mixed-citation xml:lang="en">Lew S., Hor Y., Jaafar M., et al. Lactobacilli modulated AMPK activity and prevented telomere shortening in ageing rats. Benef. Microbes. 2019;10(8):883–892. DOI: 10.3920/BM2019.0058.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Ritter A., Kreis N., Louwen F., Yuan J. Obesity and COVID-19: Molecular linking both pandemics. Int. J. Mol. Sci. 2020;21(16):5793. DOI: 10.3390/ijms21165793.</mixed-citation><mixed-citation xml:lang="en">Ritter A., Kreis N., Louwen F., Yuan J. Obesity and COVID-19: Molecular linking both pandemics. Int. J. Mol. Sci. 2020;21(16):5793. DOI: 10.3390/ijms21165793.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
