scbmtБИОМЕДИЦИНАJournal Biomed2074-59822713-0428Scientific center of biomedical technologies of Federal Medical and Biological Agency10.33647/2713-0428-17-3E-127-132scbmt-1327Research ArticleДОКЛИНИЧЕСКИЕ ИССЛЕДОВАНИЯ В БИОМЕДИЦИНЕNON-CLINICAL RESEARCH IN BIOMEDICINEИспользование модели солидной формы асцитной карциномы Эрлиха у мышей для исследования ранних и отдалённых последствий гипофракционированного протонного облученияStudy of early and remote effects of hypofractionated proton irradiation in a model of solid Ehrlich ascites carcinoma in miceБалакинВ. Е.BalakinV. E.

чл.-корр. РАН, д.ф.-м.н., 

142281, Московская обл., Протвино, Академический пр., 2

Corresponding Member of the Russian Academy of Sciences, Dr. Sci. (Phys.-Math.), 

142281, Moscow Region, Protvino, Akademicheskiy Passage, 2

balakin@ftcfian.ruБеляковаТ. А.BelyakovaT. A.

142281, Московская обл., Протвино, Академический пр., 2

142281, Moscow Region, Protvino, Akademicheskiy Passage, 2

belyakovata@lebedev.ruРозановаО. М.RozanovaO. M.

142290, Московская обл., Пущино, ул. Институтская, 3

142290, Moscow Region, Pushchino, Institutskaya Str., 3

rozanova.iteb@gmail.comСмирноваЕ. Н.SmirnovaE. N.

142290, Московская обл., Пущино, ул. Институтская, 3

142290, Moscow Region, Pushchino, Institutskaya Str., 3

smirnova.elena04@gmail.comШемяковА. Е.ShemyakovA. E.

142281, Московская обл., Протвино, Академический пр., 2;

142290, Московская обл., Пущино, ул. Институтская, 3

142281, Moscow Region, Protvino, Akademicheskiy Passage, 2;

142290, Moscow Region, Pushchino, Institutskaya Str., 3

alshemyakov@yandex.ruСтрельниковаН. С.StrelnikovaN. S.

142281, Московская обл., Протвино, Академический пр., 2

142281, Moscow Region, Protvino, Akademicheskiy Passage, 2

petunia21.02@mail.ruФилиал «Физико-технический центр» ФГБУН Физический институт им. П.Н. Лебедева РАНРоссияBranch “Physics and Technology Center” of the P.N. Lebedev Physical Institute of the Russian Academy of SciencesRussian FederationФГБУН Институт теоретической и экспериментальной биофизики РАНРоссияInstitute of Theoretical and Experimental Biophysics of the Russian Academy of SciencesRussian FederationФилиал «Физико-технический центр» ФГБУН Физический институт им. П.Н. Лебедева РАН; ФГБУН Институт теоретической и экспериментальной биофизики РАНРоссияBranch “Physics and Technology Center” of the P.N. Lebedev Physical Institute of the Russian Academy of Sciences; Institute of Theoretical and Experimental Biophysics of the Russian Academy of SciencesRussian Federation202125102021173E127132Copyright © Балакин В.Е., Белякова Т.А., Розанова О.М., Смирнова Е.Н., Шемяков А.Е., Стрельникова Н.С., 20212021Балакин В.Е., Белякова Т.А., Розанова О.М., Смирнова Е.Н., Шемяков А.Е., Стрельникова Н.С.Balakin V.E., Belyakova T.A., Rozanova O.M., Smirnova E.N., Shemyakov A.E., Strelnikova N.S.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.scbmt.ru/jour/article/view/1327

Исследовано действие тонкого сканирующего пучка протонов в дозах 60 и 80 Гр на солидную форму асцитной карциномы Эрлиха (АКЭ) у мышей. Показано, что мыши с индуцированной АКЭ являются удобной моделью для исследования схем гипофракционирования при протонной терапии. 

The effect of a pencil scanning beam of protons at doses of 60 and 80 Gy on the solid form of Ehrlich ascites carcinoma (EAC) in mice was studied. It was shown that mice with induced EAC are a convenient model for studying hypofractionation schemes under proton therapy. 

нелинейные мыши SHKасцитная карцинома Эрлихапротоныnon-inbred mice SHKEhrlich ascites carcinomaprotonsReferencesБалакин В.Е., Шемяков А.Е., Заичкина C.И. и др. Гипофракционированное облучение солидной формы асцитной карциномы Эpлиxа у мышей тонким сканирующим пучком протонов. Биофизика. 2016;61(4):808–812.Balakin V.E., Shemyakov A.E., Zaichkina S.I., et al. Gipofrakcionirovannoe obluchenie solidnoj formy ascitnoj karcinomy Jeplixa u myshej tonkim skanirujushhim puchkom protonov [Hypofractionated irradiation of the solid form of Erlich ascites carcinoma in mice by a thin scanning proton beam]. Biophysics. 2016;61(4):682–686. (In Russian).Abdel-Gawad E.I., Hassan A.I., Awwad S.A. Efficiency of calcium phosphate composite nanoparticles in targeting Ehrlich carcinoma cells transplanted in mice. J. Adv. Res. 2016;7(1):143–154. DOI: 10.1016/j.jare.2015.04.001.Abdel-Gawad E.I., Hassan A.I., Awwad S.A. Efficiency of calcium phosphate composite nanoparticles in targeting Ehrlich carcinoma cells transplanted in mice. J. Adv. Res. 2016;7(1):143–154. DOI: 10.1016/j.jare.2015.04.001.Belyakova T.A., Balakin V.E., Rozanova O.M., et al. The impact of target volumes of Ehrlich ascites carcinoma irradiated with a pencil scanning beam of protons at a total dose of 60 Gy on the tumor growth and remote effects in mice. In: Eighth International Conference on radiation in various fields of research. DOI: 10.21175/RadProc.2020.05.Belyakova T.A., Balakin V.E., Rozanova O.M., et al. The impact of target volumes of Ehrlich ascites carcinoma irradiated with a pencil scanning beam of protons at a total dose of 60 Gy on the tumor growth and remote effects in mice. In: Eighth International Conference on radiation in various fields of research. DOI: 10.21175/RadProc.2020.05.Durante M. Proton beam therapy in Europe: More centres need more research. Br. J. Cancer. 2019;120(8):777–778.Durante M. Proton beam therapy in Europe: More centres need more research. Br. J. Cancer. 2019;120(8):777–778.Rajkapoor B., Sankari M., Sumithra M., et al. Antitumor and cytotoxic effects of Phyllanthus polyphyllus on Ehrlich ascites carcinoma and human cancer cell lines. Biosci Biotechnol Biochem. 2007;71(9):2177–2183. DOI: 10.1271/bbb.70149.Rajkapoor B., Sankari M., Sumithra M., et al. Antitumor and cytotoxic effects of Phyllanthus polyphyllus on Ehrlich ascites carcinoma and human cancer cell lines. Biosci Biotechnol Biochem. 2007;71(9):2177–2183. DOI: 10.1271/bbb.70149.Smith J., van den Broek F., Martorell J., et al. Principles and practice in ethical review of animal experiments across Europe: Summary of the report of the FELASA working group on ethical evaluation of animal experiments. Laboratory Animals. 2007;41(2):143–160.Smith J., van den Broek F., Martorell J., et al. Principles and practice in ethical review of animal experiments across Europe: Summary of the report of the FELASA working group on ethical evaluation of animal experiments. Laboratory Animals. 2007;41(2):143–160.Sorensen B.S., Horsman M.R., Alsner J., et al. Relative biological effectiveness of carbon ions for tumor control, acute skin damage and late radiation-induced fibrosis in a mouse model. Acta Oncol. 2015;54(9):1623–1630. DOI: 10.3109/0284186X.2015.1069890.Sorensen B.S., Horsman M.R., Alsner J., et al. Relative biological effectiveness of carbon ions for tumor control, acute skin damage and late radiation-induced fibrosis in a mouse model. Acta Oncol. 2015;54(9):1623–1630. DOI: 10.3109/0284186X.2015.1069890.

The authors declare that there are no conflicts of interest present.