scbmtБИОМЕДИЦИНАJournal Biomed2074-59822713-0428Scientific center of biomedical technologies of Federal Medical and Biological Agency10.33647/2074-5982-15-2-69-74scbmt-135Research ArticleМЕТОДЫ БИОМЕДИЦИНСКИХ ИССЛЕДОВАНИЙMETHODS OF BIOMEDICAL RESEARCHESМЕТОДЫ ОЦЕНКИ НЕВРОЛОГИЧЕСКИХ НАРУШЕНИЙ ПРИ ЭКСПЕРИМЕНТАЛЬНОЙ ЦЕРЕБРАЛЬНОЙ ИШЕМИИMETHODS FOR ESTIMATING NEUROLOGICAL DISTURBANCES IN EXPERIMENTAL CEREBRAL ISCHEMIAБоньЕ. И.BonE. I.

к.б.н.,

230009, Республика Беларусь, Гродно, ул. Горького, д. 80

Cand. Sci. (Biol.),

230009, Republic of Belarus, Grodno, Gorkogo str., 80

asphodela@list.ruМаксимовичН. Е.MaksimovichN. Ye.

д.м.н., проф.,

230009, Республика Беларусь, Гродно, ул. Горького, д. 80

Dr. Sci. (Med.), Prof.,

230009, Republic of Belarus, Grodno, Gorkogo str., 80

mne@grsmu.byУО «Гродненский государственный медицинский университет»БеларусьGrodno State Medical UniversityBelarus201901072019026974Copyright © Бонь Е.И., Максимович Н.Е., 20192019Бонь Е.И., Максимович Н.Е.Bon E.I., Maksimovich N.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.scbmt.ru/jour/article/view/135

Изучение патологии головного мозга при экспериментальной ишемии обусловливает потребность в адекватных способах оценки возникающего у лабораторных животных неврологического дефицита, включающего сенсомоторные и поведенческие нарушения. Целью работы явилось сравнительное изучение двигательных и поведенческих нарушений у крыс с частичной и субтотальной экспериментальной церебральной ишемией. Установлено, что крысы после экспериментальной церебральной ишемии обладали меньшей мышечной силой, были менее устойчивы к гипоксии, проявляли меньшую двигательную и эмоциональную активность. У животных с субтотальной церебральной ишемией наблюдались более выраженные сенсомоторные и поведенческие нарушения по сравнению с крысами, которым моделировали частичную церебральную ишемию и, особенно, по сравнению с контрольными животными.

Investigation of the brain pathology in experimental ischemia requires adequate methods for assessing the neurological deficit that occurs in laboratory animals, including sensory-based and behavioural disorders. In this research, we aimed to compare motor and behavioural disorders in rats with partial and subtotal experimental cerebral ischemia. The rats modelled with cerebral ischemia are found to exhibit a decrease in muscle strength, resistance to hypoxia, motor and emotional activity. The animals with incomplete cerebral ischemia demonstrated more pronounced sensory-based motor and behavioural disorders compared both with those modelled with partial cerebral ischemia and, in particular, with the control group.

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The authors declare that there are no conflicts of interest present.