scbmtБИОМЕДИЦИНАJournal Biomed2074-59822713-0428Scientific center of biomedical technologies of Federal Medical and Biological Agency10.33647/2074-5982-18-2-63-76scbmt-1389Research ArticleРЕЛЕВАНТНОЕ И АЛЬТЕРНАТИВНОЕ БИОМОДЕЛИРОВАНИЕRELEVANT AND ALTERNATIVE BIOMODELLINGСравнительное исследование инъекционных имплантатов на основе микрочастиц различных биодеградируемых материалов в модели подкожной имплантации у мышейComparative Study of Injectable Implants Based on Microparticles of Various Biodegradable Materials in a Murine Model of Subcutaneous ImplantationДемьяненкоИ. А.DemyanenkoI. A.

 к.б.н.,

 123098, Российская Федерация, Москва, ул. Гамалеи, 18 

 Cand. Sci. (Biol.) 

123098, Russian Federation, Moscow, Gamaleya Str., 18

ilya871@rambler.ruШишкинаА. В.ShishkinaA. V.

 к.х.н., 

 123098, Российская Федерация, Москва, ул. Гамалеи, 18 

 Cand. Sci. (Biol.) 

 123098, Russian Federation, Moscow, Gamaleya Str., 18 

ХацЮ. С.HatsYu. S.

123098, Российская Федерация, Москва, ул. Гамалеи, 18 

 123098, Russian Federation, Moscow, Gamaleya Str., 18 

КалмыковаН. В.KalmykovaN. V.

 к.б.н., 

 123098, Российская Федерация, Москва, ул. Гамалеи, 18 

 Cand. Sci. (Biol.) 

 123098, Russian Federation, Moscow, Gamaleya Str., 18 

ФГБУ «Национальный исследовательский центр эпидемиологии и микробиологии имени почётного академика Н.Ф. Гамалеи» Минздрава РоссииРоссияNational Research Center for Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya of the Ministry of Health Care of RussiaRussian Federation2022100620221826376Copyright © Демьяненко И.А., Шишкина А.В., Хац Ю.С., Калмыкова Н.В., 20222022Демьяненко И.А., Шишкина А.В., Хац Ю.С., Калмыкова Н.В.Demyanenko I.A., Shishkina A.V., Hats Y.S., Kalmykova N.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.scbmt.ru/jour/article/view/1389

Проведено сравнительное исследование двух коммерчески доступных инъекционных имплантатов на основе микрочастиц различных биодеградируемых материалов (гидроксиапатита кальция и стабилизированного коллагена) в модели подкожной имплантации у мышей. Показано, что в использованной экспериментальной модели оба имплантата эффективно замещали объём мягких тканей. Резорбция имплантатов сопровождалась умеренным хроническим воспалительным ответом. Имплантат на основе микрочастиц гидроксиапатита кальция подвергался выраженному постинъекционному обводнению на 1-е сутки после введения, характеризовался более выраженной миграцией из точки инъекции и более ранним началом процесса замещения микрочастиц аутологичными волокнами коллагена, сопровождающего его биодеградацию. В свою очередь, имплантат на основе микрочастиц стабилизированного коллагена оказывал больший эффект лифтинга на кожу в месте введения, а также дольше сохранял эффект объёмной коррекции в течение 12 мес. эксперимента.

A comparative study of two commercially available injectable implants based on microparticles of various biodegradable materials (calcium hydroxyapatite and cross-linked collagen) was carried out using a murine model of subcutaneous implantation. The developed experimental model showed that both implants effectively replace the volume of soft tissues. Implant resorption was accompanied by a moderate chronic inflammatory response. The implant based on calcium hydroxyapatite microparticles caused pronounced post-injection swelling at 1 day after administration and demonstrated a more pronounced migration from the injection point. For this implant, an earlier onset of the process of replacing microparticles with autologous collagen fibers, accompanying its biodegradation, was observed. The implant based on cross-linked collagen microparticles had a greater lifting effect at the injection site and retained a longer effect of skin augmentation lasting for 12 months.

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The authors declare that there are no conflicts of interest present.