scbmtБИОМЕДИЦИНАJournal Biomed2074-59822713-0428Scientific center of biomedical technologies of Federal Medical and Biological Agency10.33647/2074-5982-18-3-14-17scbmt-1402Research ArticleМЕТОДЫ И ТЕХНОЛОГИИ БИОМЕДИЦИНСКИХ ИССЛЕДОВАНИЙMETHODS AND TECHNOLOGIES OF BIOMEDICAL RESEARCHОценка одиночных нуклеотидных полиморфизмов человеческого сывороточного альбумина, ассоциированных с болезнью АльцгеймераEvaluation of Single-Nucleotide Polymorphisms in Human Serum Albumin Associated with Alzheimer's DiseaseДерюшеваЕ. И.DeryushevaE. I.

Дерюшева Евгения Игоревна - кандидат физико-математических наук.

142290, Московская обл., Пущино, просп. Науки, 3.

Evgeniya I. Deryusheva - Cand. Sci. (Phis.-Math.), Federal Research Center “Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences”.

142290, Moscow Region, Pushchino, Nauki Ave., 3.

evgenia.deryusheva@gmail.comЛитусЕ. А.LitusE. A.

Литус Екатерина Андреевна - кандидат медицинских наук.

142290, Московская обл., Пущино, просп. Науки, 3.

Ekaterina A. Litus - Cand. Sci. (Med.), Federal Research Center “Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences”.

142290, Moscow Region, Pushchino, Nauki Ave., 3.

ealitus@gmail.comФГБУН «Федеральный исследовательский центр «Пущинский научный центр биологических исследований РAH»РоссияFederal Research Center “Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences”Russian Federation2022161020221831417Copyright © Дерюшева Е.И., Литус Е.А., 20222022Дерюшева Е.И., Литус Е.А.Deryusheva E.I., Litus E.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.scbmt.ru/jour/article/view/1402

Человеческий сывороточный альбумин (ЧСА) является природным буфером амилоидного β-пептида (Аβ), ключевого фактора развития болезни Альцгеймера (БА). Увеличение сродства ЧСА к Aβ может достигаться путём насыщения ЧСА низкомолекулярными лигандами, такими как серотонин, отдельные жирные кислоты. Анализ геномных данных экзомов (WES), ассоциированных с БА (база данных ADSP), выявил наличие однонуклеотидного полиморфизма гена ЧСА в центрах связывания ибупрофена, арахидоновой и олеиновой кислот. Исследование свойств найденных генетических вариантов ЧСА позволит определить варианты, восприимчивые к модулирующему воздействию лигандов ЧСА, повышающих его сродство к Аβ.

Human serum albumin (HSA) is a natural buffer for amyloid в peptide (Аβ), which is a key factor in the development of Alzheimer's disease (AD). An increase in HSA affinity to Аβ can be achieved via HSA saturation with low-molecular-weight ligands, such as serotonin or specific fatty acids. The conducted analysis of the genomic data of exomes (WES) associated with AD (ADSP database) revealed the presence of a single-nucleotide polymorphism of the HSA gene at the binding sites of ibuprofen, arachidonic and oleic acids. Research into the properties of the revealed genetic variants of HSA should be carried out to determine those variants that are susceptible to the modulatory action of HSA ligands, thus increasing its affinity to Aβ.

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The authors declare that there are no conflicts of interest present.