scbmtБИОМЕДИЦИНАJournal Biomed2074-59822713-0428Scientific center of biomedical technologies of Federal Medical and Biological Agency10.33647/2074-5982-18-3-118-121scbmt-1423Research ArticleДОКЛИНИЧЕСКИЕ ИССЛЕДОВАНИЯ В БИОМЕДИЦИНЕNON-CLINICAL RESEARCH IN BIOMEDICINEЭкзогенные РНК как потенциальные фармакологические агентыExogenous RNAs as Potential Pharmacological AgentsОковитыйС. В.OkovitiyS. V.

Оковитый Сергей Владимирович - доктор медицинских наук, профессор.

197376, Санкт-Петербург, ул. Профессора Попова, 14, лит. А.

Sergey V. Okovitiy - Dr. Sci. (Med.), Prof., St. Petersburg State Chemical and Pharmaceutical University of the Ministry of Health Care of Russia.

197376, St. Petersburg, Professora Popova Str., 14, lit. A.

okovity@pharminnotech.comШустовЕ. Б.ShustovE. B.

Шустов Евгений Борисович - доктор медицинских наук, профессор.

197376, Санкт-Петербург, ул. Профессора Попова, 14, лит. А.

Evgeniy B. Shustov - Dr. Sci. (Med.), Prof., St. Petersburg State Chemical and Pharmaceutical University of the Ministry of Health Care of Russia.

197376, St. Petersburg, Professora Popova Str., 14, lit. A.

evgeniy.shustov@pharminnotech.comФГБОУ ВО «Санкт-Петербургский государственный химико-фармацевтический университет» Минздрава РоссииРоссияSt. Petersburg State Chemical and Pharmaceutical University of the Ministry of Health Care of RussiaRussian Federation202218102022183118121Copyright © Оковитый С.В., Шустов Е.Б., 20222022Оковитый С.В., Шустов Е.Б.Okovitiy S.V., Shustov E.B.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.scbmt.ru/jour/article/view/1423

Экзогенные РНК видонеспецифически изменяют передачу сигналов в тканях, регулируя экспрессию генов, что приводит к фенотипическим изменениям в клетках, а их применение может стать основой для новой тактики регуляторной профилактики и терапии различных заболеваний. Технологии экзогенных РНК являются перспективным подходом к созданию принципиально нового класса лекарственных препаратов или биологически активных добавок (для растительных экзогенных РНК) с широким спектром фармакологической активности и минимальным количеством побочных эффектов.

Exogenous RNAs alter interspecifically the transmission of signals in organisms by regulating the expression of their genes. This process leads to phenotypic cellular changes, thus representing a possible new tactic for the treatment of various diseases. Exogenous RNAs are a promising approach to the creation of a fundamentally new class of drugs or biologically active additives (for plant exogenous RNAs) with a promising pharmacological activity and minimal side effects.

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The authors declare that there are no conflicts of interest present.