scbmtБИОМЕДИЦИНАJournal Biomed2074-59822713-0428Scientific center of biomedical technologies of Federal Medical and Biological Agency10.33647/2074-5982-18-3-122-127scbmt-1424Research ArticleДОКЛИНИЧЕСКИЕ ИССЛЕДОВАНИЯ В БИОМЕДИЦИНЕNON-CLINICAL RESEARCH IN BIOMEDICINEАдаптогенные и нейропротективные свойства аскорбата литияAdaptogenic and Neuroprotective Properties of Lithium AscorbateОстренкоК. С.OstrenkoK. S.

Остренко Константин Сергеевич - доктор биологических наук.

249013, Калужская обл., Боровск, пос. Институт.

Konstantin S. Ostrenko - Dr. Sci. (Biol.). All-Russian Research Institute of Physiology, Biochemistry and Animal Nutrition — branch of the Federal Scientific Center of Animal Husbandry — The All-Russian Institute of Animal Husbandry named after academician L.K. Ernst.

249013, Kaluga Region, Borovsk, Institut Village.

Ostrenkoks@gmail.comГромоваО. А.GromovaO. A.

Громова Ольга Алексеевна – доктор медицинских наук, профессор.

119333, Москва, ул. Вавилова, 44, корп. 2.

Olga A. Gromova - Dr. Sci. (Med.), Prof., Federal Research Center “Computer Science and Control” of the Russian Academy of Sciences.

119333, Moscow, Vavilova Str., 44/2.

unesco.gromova@gmail.comРасташанскийВ. В.RastashanskyV. V.

Расташанский Вячеслав Валерьевич.

121205, Москва, терр. инновационного центра Сколково, ул. Нобеля, 5.

Vyacheslav V. Rastashansky.

121205, Moscow, terr. of the Innovation Center Skolkovo, Nobelya Str., 5.

normotim@yandex.ruВсероссийский научно-исследовательский институт физиологии, биохимии и питания животных — филиал ФГБНУ «Федеральный научный центр животноводства — ВИЖ им. акад. Л.К. Эрнста»РоссияAll-Russian Research Institute of Physiology, Biochemistry and Animal Nutrition — branch of the Federal Scientific Center of Animal Husbandry — The All-Russian Institute of Animal Husbandry named after Academician L.K. ErnstRussian FederationФГУ «Федеральный исследовательский центр “Информатика и управление” РАН»РоссияFederal Research Center “Computer Science and Control” of the Russian Academy of SciencesRussian FederationООО «Нормофарм»РоссияNormopharmRussian Federation202218102022183122127Copyright © Остренко К.С., Громова О.А., Расташанский В.В., 20222022Остренко К.С., Громова О.А., Расташанский В.В.Ostrenko K.S., Gromova O.A., Rastashansky V.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.scbmt.ru/jour/article/view/1424

Цель исследования — изучение нейропротективных свойств аскорбата лития в моделях стресса in vivo и in vitro. Проведены нейроцитологические и поведенческие исследования на моделях стресса в культуре нервных клеток и у экспериментальных животных. Показан выраженный нейропротективный эффект аскорбата лития при цитотоксическом действии глутамата in vitro и его адаптогенный эффект при индукции стресса in vivo. Результаты указывают на высокий нейропротективный потенциал аскорбата лития в условиях стресса, индуцируемого in vivo и in vitro.

In this work, we study the neuroprotective properties of lithium ascorbate in in vivo and in vitro stress models. Neurocytological and behavioral studies were carried out on models of stress in both a culture of nerve cells and experimental animals. The studied drug showed a significant neuroprotective effect of lithium ascorbate in neuronal cultures exposed to glutamate toxicity and an adaptogenic effect in stress models in rats. The results suggest that lithium ascorbate possess a high neuroprotective potential in stress models in vivo and in vitro.

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The authors declare that there are no conflicts of interest present.