scbmtБИОМЕДИЦИНАJournal Biomed2074-59822713-0428Scientific center of biomedical technologies of Federal Medical and Biological Agency10.33647/2074-5982-19-2-54-60scbmt-1476Research ArticleДОКЛИНИЧЕСКИЕ ИССЛЕДОВАНИЯ В БИОМЕДИЦИНЕNON-CLINICAL RESEARCH IN BIOMEDICINEРеакция CD68-положительных клеток тимуса у крыс при введении селена и канцерогенаResponse of CD68-Positive Thymic Cells in Rats to Selenium and Carcinogen AdministrationБубноваН. В.BubnovaN. V.

Бубнова Наталья Владимировна.

428015, Чебоксары, Московский пр., 15

Natalia V. Bubnova.

428015, Cheboksary, Moskovsky Ave., 15

natalia210485@yandex.ruФГБОУ ВО «Чувашский государственный университет им. И.Н. Ульянова»РоссияI.N. Ulyanov Chuvash State UniversityRussian Federation2023100620231925460Copyright © Бубнова Н.В., 20232023Бубнова Н.В.Bubnova N.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.scbmt.ru/jour/article/view/1476

Макрофаги являются ключевыми клетками тимуса, которые принимают участие в антигеннезависимой дифференцировке Т-лимфоцитов и их дальнейшей селекции. По уровню макрофагов можно судить об изменении функций исследуемого органа. Селен является незаменимым микроэлементом, который входит в состав множества белков и ферментов, обеспечивающих цитопротективное, антимутагенное и антиканцерогенное действие. Также он играет значительную роль в функционировании иммунной системы, увеличивая активность естественных киллеров, продукцию интерлейкинов и стимулируя фагоцитоз. Главная цель данного исследования — изучение реакции макрофагов тимуса на фоне приёма селена и введения химического канцерогена. В ходе эксперимента выявлено увеличение уровня CD68-положительных клеток у всех опытных животных, получавших селен, канцероген и при сочетанном влиянии этих факторов, что может быть связано с иммуностимулирующим действием селена.

Macrophages are the key thymic cells that take part in the antigen-independent differentiation of T-lymphocytes and their further selection. The level of macrophages indicates changes in the functions of the organ under study. As an essential trace element, selenium is part of a variety of proteins and enzymes, which perform cytoprotective, antimutagenic, and anticancerogenic action. Selenium also plays a significant role in the functioning of the immune system, increasing the activity of natural killers, production of interleukins, and stimulation of phagocytosis. This study was aimed at investigating the response of thymic macrophages to the administration of selenium and a chemical carcinogen. During the experiment, an increase in the level of CD68-positive cells was revealed in all experimental animals receiving selenium and a carcinogen, as well as under their combined action. The observed effects were assumed to be related to the immune-stimulating effect of selenium.

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The authors declare that there are no conflicts of interest present.