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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">scbmt</journal-id><journal-title-group><journal-title xml:lang="ru">БИОМЕДИЦИНА</journal-title><trans-title-group xml:lang="en"><trans-title>Journal Biomed</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2074-5982</issn><issn pub-type="epub">2713-0428</issn><publisher><publisher-name>Scientific center of biomedical technologies of Federal Medical and Biological Agency</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.33647/2713-0428-19-3E-130-135</article-id><article-id custom-type="elpub" pub-id-type="custom">scbmt-1525</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>БИОМЕДИЦИНСКИЕ ТЕХНОЛОГИИ В КЛИНИЧЕСКИХ ИССЛЕДОВАНИЯХ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>BIOMEDICAL TECHNOLOGIES IN CLINICAL RESEARCH</subject></subj-group></article-categories><title-group><article-title>Особенности клинического течения и способы терапии аквагенной крапивницы</article-title><trans-title-group xml:lang="en"><trans-title>Clinical Course and Therapy Methods of Aquagenic Urticaria</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Куделина</surname><given-names>О. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Kudelina</surname><given-names>O. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Куделина Оксана Михайловна - кандидат медицинских наук.</p><p>344022, Ростов-на-Дону, пер. Нахичеванский, 29</p></bio><bio xml:lang="en"><p>Oksana M. Kudelina - Cand. Sci. (Med.).</p><p>344022, Rostov-on-Don, Nakhichevansky Lane, 29</p></bio><email xlink:type="simple">kuomi81@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ганцгорн</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Gantsgorn</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ганцгорн Елена Владимировна - кандидат медицинских наук, доцент.</p><p>344022, Ростов-на-Дону, пер. Нахичеванский, 29</p></bio><bio xml:lang="en"><p>Elena V. Gantsgorn - Cand. Sci. (Med.), Assoc. Prof.</p><p>344022, Rostov-on-Don, Nakhichevansky Lane, 29</p></bio><email xlink:type="simple">gantsgorn@inbox.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Макляков</surname><given-names>Ю. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Maklyakov</surname><given-names>Yu. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Макляков Юрий Степанович - кандидат медицинских наук, профессор.</p><p>344022, Ростов-на-Дону, пер. Нахичеванский, 29</p></bio><bio xml:lang="en"><p>Yuri S. Maklyakov - Dr. Sci. (Med.), Prof.</p><p>344022, Rostov-on-Don, Nakhichevansky Lane, 29</p></bio><email xlink:type="simple">maklus005@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ткаченко</surname><given-names>Д. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Tkachenko</surname><given-names>D. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ткаченко Дарья Леонидовна</p><p>344022, Ростов-на-Дону, пер. Нахичеванский, 29</p></bio><bio xml:lang="en"><p>Darya L. Tkachenko</p><p>344022, Rostov-on-Don, Nakhichevansky Lane, 29</p></bio><email xlink:type="simple">t_darya2301@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Авакян</surname><given-names>Л. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Avakyan</surname><given-names>L. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Авакян Лилия Ашотовна</p><p>344022, Ростов-на-Дону, пер. Нахичеванский, 29</p></bio><bio xml:lang="en"><p>Lilia A. Avakyan</p><p>344022, Rostov-on-Don, Nakhichevansky Lane, 29</p></bio><email xlink:type="simple">lilyforever02@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чубырева</surname><given-names>П. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Chubyreva</surname><given-names>P. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Чубырева Полина Алексеевна</p><p>344022, Ростов-на-Дону, пер. Нахичеванский, 29</p></bio><bio xml:lang="en"><p>Polina A. Chubyreva</p><p>344022, Rostov-on-Don, Nakhichevansky Lane, 29</p></bio><email xlink:type="simple">chubyrevapolina@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Амирова</surname><given-names>У. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Amirova</surname><given-names>Y. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Амирова Ульяна Газиевна</p><p>344022, Ростов-на-Дону, пер. Нахичеванский, 29</p></bio><bio xml:lang="en"><p>Yliana G. Amirova</p><p>344022, Rostov-on-Don, Nakhichevansky Lane, 29</p></bio><email xlink:type="simple">amirova.yliana@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Карпова</surname><given-names>Ю. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Karpova</surname><given-names>Yu. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Карпова Юлия Александровна</p><p>344022, Ростов-на-Дону, пер. Нахичеванский, 29</p></bio><bio xml:lang="en"><p>Yulia A. Karpova</p><p>344022, Rostov-on-Don, Nakhichevansky Lane, 29</p></bio><email xlink:type="simple">yulka171102@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дульская</surname><given-names>А. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Dulskaya</surname><given-names>A. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Дульская Алина Николаевна</p><p>344022, Ростов-на-Дону, пер. Нахичеванский, 29</p></bio><bio xml:lang="en"><p>Alina N. Dulskaya</p><p>344022, Rostov-on-Don, Nakhichevansky Lane, 29</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Месхи</surname><given-names>И. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Meshi</surname><given-names>I. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Месхи Иракли Бесикович</p><p>344022, Ростов-на-Дону, пер. Нахичеванский, 29</p></bio><bio xml:lang="en"><p>Irakly B. Meshi</p><p>344022, Rostov-on-Don, Nakhichevansky Lane, 29</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Ростовский государственный медицинский университет» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Rostov State Medical University of the Ministry of Health Care of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>21</day><month>11</month><year>2023</year></pub-date><volume>19</volume><issue>3E</issue><fpage>130</fpage><lpage>135</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Куделина О.М., Ганцгорн Е.В., Макляков Ю.С., Ткаченко Д.Л., Авакян Л.А., Чубырева П.А., Амирова У.Г., Карпова Ю.А., Дульская А.Н., Месхи И.Б., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Куделина О.М., Ганцгорн Е.В., Макляков Ю.С., Ткаченко Д.Л., Авакян Л.А., Чубырева П.А., Амирова У.Г., Карпова Ю.А., Дульская А.Н., Месхи И.Б.</copyright-holder><copyright-holder xml:lang="en">Kudelina O.M., Gantsgorn E.V., Maklyakov Y.S., Tkachenko D.L., Avakyan L.A., Chubyreva P.A., Amirova Y.G., Karpova Y.A., Dulskaya A.N., Meshi I.B.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.scbmt.ru/jour/article/view/1525">https://journal.scbmt.ru/jour/article/view/1525</self-uri><abstract><p>Аквагенная крапивница — одна из наиболее редких форм аллергической реакции организма. Клинически проявляется зудом, уртикарными высыпаниями спустя 5–10 мин после контакта с водой и их исчезновением в течение 30–60 мин. Базисная терапия включает назначение блокаторов H1-гистаминовых рецепторов II поколения и барьерных кремов с церамидами. В последние годы рассматривается применение терапии моноклональными антителами (омализумаб) в случае неэффективности антигистаминных препаратов.</p></abstract><trans-abstract xml:lang="en"><p>Aquagenic urticaria is one of the rarest forms of allergic reaction in the body. Aquagenic urticaria is clinically manifested by itching and urticarial rashes 5–10 min after contact with water. The signs disappear within 30–60 min. The standard therapy regimen includes the administration of second-generation H1-histamine receptor blockers and barrier creams with ceramides. In recent years, the use of monoclonal antibody therapy (omalizumab) has been considered in cases where antihistamines are ineffective.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>аквагенная крапивница</kwd><kwd>хроническая индуцированная крапивница</kwd><kwd>блокаторы H1-гистаминовых рецепторов</kwd><kwd>омализумаб</kwd></kwd-group><kwd-group xml:lang="en"><kwd>aquagenic urticaria</kwd><kwd>chronic inducible urticaria</kwd><kwd>H1-antihistamines</kwd><kwd>omalizumab</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Крапивница. Клин. реком. Российское общество дерматовенерологов и косметологов, Российская ассоциация аллергологов и клинических иммунологов. М., 2020.</mixed-citation><mixed-citation xml:lang="en">Clinical guidelines: urticarial]. Russian Society of Dermatovenerologists and Cosmetologists, Russian Association of Allergology and Clinical Immunology. 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