scbmtБИОМЕДИЦИНАJournal Biomed2074-59822713-0428Scientific center of biomedical technologies of Federal Medical and Biological Agency10.33647/2074-5982-21-2-71-80scbmt-1717Research ArticleДОКЛИНИЧЕСКИЕ ИССЛЕДОВАНИЯ В БИОМЕДИЦИНЕNON-CLINICAL RESEARCH IN BIOMEDICINEКлеточный состав надпочечников крыс-самцов при введении уретанаCellular Composition of Male Rat Adrenal Glands upon Urethane AdministrationТимофееваН. Ю.TimofeevaN. Yu.

Тимофеева Наталья Юрьевна 

428015, Чувашская Республика, Чебоксары, Московский пр-т, 15 

Natalia Yu. Timofeeva 

428015, Chuvash Republic, Cheboksary, Moskovskiy Ave., 15

bla11blabla@yandex.ruСтручкоГ. Ю.StruchkoG. Yu.

Стручко Глеб Юрьевич, д.м.н., проф. 

428015, Чувашская Республика, Чебоксары, Московский пр-т, 15 

Gleb Yu. Struchko, Dr. Sci. (Med.), Prof. 

428015, Chuvash Republic, Cheboksary, Moskovskiy Ave., 15

glebstr@mail.ruМеркуловаЛ. М.MerkulovaL. M.

Меркулова Лариса Михайловна, д.м.н., проф. 

428015, Чувашская Республика, Чебоксары, Московский пр-т, 15 

Larisa M. Merkulova, Dr. Sci. (Med.), Prof. 

428015, Chuvash Republic, Cheboksary, Moskovskiy Ave., 15

merkulova192@mail.ruКостроваО. Ю.KostrovaO. Yu.

Кострова Ольга Юрьевна, к.м.н., доц. 

428015, Чувашская Республика, Чебоксары, Московский пр-т, 15 

Olga Yu. Kostrova, Cand. Sci. (Med.), Assoc. Prof.

428015, Chuvash Republic, Cheboksary, Moskovskiy Ave., 15

evkbiz@yandex.ruСтоменскаяИ. С.StomenskayaI. S.

Стоменская Ирина Станиславовна, к.м.н., доц. 

428015, Чувашская Республика, Чебоксары, Московский пр-т, 15 

Irina S. Stomenskaya, Cand. Sci. (Med.), Assoc. Prof.

428015, Chuvash Republic, Cheboksary, Moskovskiy Ave., 15

irina.stomenskaja@gmail.comМосквичевЕ. В.MoskvichevE. V.

Москвичев Евгений Васильевич, д.м.н. 

428015, Чувашская Республика, Чебоксары, Московский пр-т, 15 

Evgenij V. Moskvichev, Dr. Sci. (Med.) 

428015, Chuvash Republic, Cheboksary, Moskovskiy Ave., 15

moskvichev@rambler.ruФГБОУ ВО «Чувашский государственный университет имени И.Н. Ульянова»РоссияI.N. Ulyanov Chuvash State UniversityRussian Federation2025040720252127180Copyright © Тимофеева Н.Ю., Стручко Г.Ю., Меркулова Л.М., Кострова О.Ю., Стоменская И.С., Москвичев Е.В., 20252025Тимофеева Н.Ю., Стручко Г.Ю., Меркулова Л.М., Кострова О.Ю., Стоменская И.С., Москвичев Е.В.Timofeeva N.Y., Struchko G.Y., Merkulova L.M., Kostrova O.Y., Stomenskaya I.S., Moskvichev E.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.scbmt.ru/jour/article/view/1717

Надпочечники представляют собой эндокринный орган, участвующий в регуляции практически всех жизненно важных процессов в организме. Работа основных структурных элементов надпочечников — кортикоцитов и хромаффинных клеток — во многом зависит от клеточного микроокружения. Известно, что в структуру паренхимы надпочечников входят лимфоциты, макрофаги, мастоциты и другие клетки. Уретан является одним из химических стрессоров, который способен влиять на структуру надпочечников. В данной статье представлено изучение изменений клеточного состава надпочечников при действии уретана. Выявлено, что однократное внутрибрюшинное введение уретана крысам-самцам приводит к изменениям в структуре надпочечников в виде уменьшения числа пролиферирующих клеток и мастоцитов, увеличения числа фибробластов и макрофагов и инфильтрации органа лимфоцитами, преимущественно NK-клетками.

The adrenal glands are an endocrine organ involved in the regulation of almost all vital processes in the body. Functioning of the main structural elements of the adrenal glands – corticocytes and chromaffin cells – largely depends on the cellular microenvironment. It is known that the structure of the adrenal parenchyma includes lymphocytes, macrophages, mastocytes, and other cells. Urethane is a chemical stressor that can affect the structure of the adrenal gland. This paper presents a study of the changes in the cellular composition of the adrenal glands under the administration of urethane. It was found that a single intraperitoneal injection of urethane into male rats leads to changes in the structure of the adrenal glands manifested in a decreased number of proliferating cells and mastocytes, an increased number of fibroblasts and macrophages, and infiltration of the organ with lymphocytes, mainly NK-cells.

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The authors declare that there are no conflicts of interest present.