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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">scbmt</journal-id><journal-title-group><journal-title xml:lang="ru">БИОМЕДИЦИНА</journal-title><trans-title-group xml:lang="en"><trans-title>Journal Biomed</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2074-5982</issn><issn pub-type="epub">2713-0428</issn><publisher><publisher-name>Scientific center of biomedical technologies of Federal Medical and Biological Agency</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.33647/2074-5982-21-3-78-81</article-id><article-id custom-type="elpub" pub-id-type="custom">scbmt-1761</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>МЕТОДЫ И ТЕХНОЛОГИИ БИОМЕДИЦИНСКИХ ИССЛЕДОВАНИЙ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>METHODS AND TECHNOLOGIES OF BIOMEDICAL RESEARCH</subject></subj-group></article-categories><title-group><article-title>Декремент-тест как метод функциональной оценки нервно-мышечной передачи при экспериментальных исследованиях</article-title><trans-title-group xml:lang="en"><trans-title>Repetitive Nerve Stimulation for Functional Assessment of Neuromuscular Transmission in Experimental Studies</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тюнин</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Tyunin</surname><given-names>M. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Mikhail A. Tyunin - Cand. Sci. (Med.)</p><p>195043, Санкт-Петербург, ул. Лесопарковая, 4</p></bio><bio xml:lang="en"><p>Mikhail A. Tyunin - Cand. Sci. (Med.)</p><p>195043, Saint Petersburg, Lesoparkovaya Str., 4</p></bio><email xlink:type="simple">gniiivm_7@mil.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мацейчик</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Macejchik</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мацейчик Владимир Анатольевич</p><p>127994, Москва, Рахмановский пер., 3</p></bio><bio xml:lang="en"><p>Vladimir A. Macejchik</p><p>127994, Moscow, Rakhmanovskyj Lane, 3</p></bio><email xlink:type="simple">gniiivm_7@mil.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ильинский</surname><given-names>Н. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Ilinskiy</surname><given-names>N. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ильинский Никита Сергеевич - к.м.н.</p><p>195043, Санкт-Петербург, ул. Лесопарковая, 4</p></bio><bio xml:lang="en"><p>Nikita S. Ilinskiy - Cand. Sci. (Med.).</p><p>195043, Saint Petersburg, Lesoparkovaya Str., 4</p></bio><email xlink:type="simple">gniiivm_7@mil.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Старшова</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Starshova</surname><given-names>I. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Старшова Ирина Владимировна</p><p>195043, Санкт-Петербург, ул. Лесопарковая, 4</p></bio><bio xml:lang="en"><p>Irina V. Starshova</p><p>195043, Saint Petersburg, Lesoparkovaya Str., 4</p></bio><email xlink:type="simple">gniiivm_7@mil.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ижорская</surname><given-names>Е. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Izhorskaya</surname><given-names>E. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ижорская Елизавета Юрьевна</p><p>195043, Санкт-Петербург, ул. Лесопарковая, 4</p></bio><bio xml:lang="en"><p>Elizaveta Yu. Izhorskaya</p><p>195043, Saint Petersburg, Lesoparkovaya Str., 4</p></bio><email xlink:type="simple">gniiivm_7@mil.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ «Государственный научно-исследовательский испытательный институт военной медицины» Минобороны России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>State Scientific Research Testing Institute of Military Medicine of the Ministry of Defence of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Департамент науки и инновационного развития Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Departament of Science and Innovative Development of the Ministry of Health Сare of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>19</day><month>10</month><year>2025</year></pub-date><volume>21</volume><issue>3</issue><fpage>78</fpage><lpage>81</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Тюнин М.А., Мацейчик В.А., Ильинский Н.С., Старшова И.В., Ижорская Е.Ю., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Тюнин М.А., Мацейчик В.А., Ильинский Н.С., Старшова И.В., Ижорская Е.Ю.</copyright-holder><copyright-holder xml:lang="en">Tyunin M.A., Macejchik V.A., Ilinskiy N.S., Starshova I.V., Izhorskaya E.Y.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.scbmt.ru/jour/article/view/1761">https://journal.scbmt.ru/jour/article/view/1761</self-uri><abstract><p>Представлено сравнительное описание типичных электромиографических паттернов нарушений нервно-мышечной передачи на фоне введения различных холинэргических средств. Результаты исследования пригодны для моделирования патологии периферической нервной системы и проведения доклинических исследований в области нейрофармакологии и нейротоксикологии.</p></abstract><trans-abstract xml:lang="en"><p>This article presents a comparative description of typical electromyographic patterns of neuromuscular transmission disturbances due to effects of various cholinergic agents. The results obtained can be used when modeling pathologies of the peripheral nervous system and conducting preclinical studies in the field of neuropharmacology and neurotoxicology.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>ритмическая стимуляция</kwd><kwd>нервно-мышечная передача</kwd><kwd>нейротоксичность</kwd></kwd-group><kwd-group xml:lang="en"><kwd>repetitive nerve stimulation</kwd><kwd>neuromuscular transmission</kwd><kwd>neurotoxicity</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Ильинский Н.С., Тюнин М.А., Матросова М.О. Методические подходы к оценке паралитического синдрома токсического генеза в экспериментах на грызунах. Лаб. жив. для научн. исслед. 2021;(3):70–74.</mixed-citation><mixed-citation xml:lang="en">Ilinskiy N.S., Tyunin M.A., Matrosova M.O. 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