scbmtБИОМЕДИЦИНАJournal Biomed2074-59822713-0428Scientific center of biomedical technologies of Federal Medical and Biological Agencyscbmt-241Research ArticleРЕЛЕВАНТНОЕ И АЛЬТЕРНАТИВНОЕ БИОМОДЕЛИРОВАНИЕRELEVANT AND ALTERNATIVE BIOMODELLINGСовременные экспериментальные модели депрессииCurrent experimental models of depressionЯузинаН. А.YauzinaN. A.nina.a.k.85@mail.ruКомлеваЮ. К.KomlevaYu. K.noemail@neicon.ruСалминаА. Б.SalminaA. B.noemail@neicon.ruПетроваМ. М.PetrovaM. M.noemail@neicon.ruМорозоваГ. А.MorozovaG. A.noemail@neicon.ruМалиновскаяН. А.MalinovskayaN. A.noemail@neicon.ruГерцогГ. Е.G.enoemail@neicon.ruКрасноярский государственный медицинский университет им. проф. В.Ф. ВойноЯсенецкого, КрасноярскРоссия201320012020116171Copyright © Яузина Н.А., Комлева Ю.К., Салмина А.Б., Петрова М.М., Морозова Г.А., Малиновская Н.А., Герцог Г.Е., 20202020Яузина Н.А., Комлева Ю.К., Салмина А.Б., Петрова М.М., Морозова Г.А., Малиновская Н.А., Герцог Г.Е.Yauzina N.A., Komleva Y.K., Salmina A.B., Petrova M.M., Morozova G.A., Malinovskaya N.A., Герцог Г.Е.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.scbmt.ru/jour/article/view/241

This review covers basic fundamental models of experimental modeling of depression and methods of experimental modeling of behavioral alterations. Animal models are promising enough for the understanding of psychopathotology, but not as a deviations of behavior, as well as a series of psychological processes that obey certain laws. Creating models of depression is experiencing a period of prosperity. There are several models of depression: chronic mild stress model, social conflict model, leaned helplessness model, water- immersion model. Many of them are based on some manipulation of the animals behavior, which have know biological effects. The investigation of the behavior of laboratory animals and modeling of depression allows detail characteristic features of psychopatology in humans.

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The authors declare that there are no conflicts of interest present.