scbmtБИОМЕДИЦИНАJournal Biomed2074-59822713-0428Scientific center of biomedical technologies of Federal Medical and Biological Agencyscbmt-299Research ArticleСтатьиМоделирование увеоретинита и ретинопатии как инструмент изучения их иммунопатогенезаModelling of uveoretinitis and retinopathy as a tool for study of their immunopathogenesisДикиновЗ. Х.DikinovZ. H.noemail@neicon.ruЕвсегнееваИ. В.EvsegneevaI. V.noemail@neicon.ruКалюжинО. В.KalyuzhinO. V.kalyuzhin@list.ruКабардино-Балкарский государственный университет им. Х.М. Бербекова, НальчикRussian FederationПервый МГМУ им. И.М. Сеченова, МоскваRussian FederationНаучно-исследовательский институт морфологии человека РАМН, МоскваRussian Federation201420012020112737Copyright © Дикинов З.Х., Евсегнеева И.В., Калюжин О.В., 20202020Дикинов З.Х., Евсегнеева И.В., Калюжин О.В.Dikinov Z.H., Evsegneeva I.V., Kalyuzhin O.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.scbmt.ru/jour/article/view/299

Моделирование увеоретинита и ретинопатии на животных и клеточных культурах явилось важнейшим шагом на пути не только к раскрытию иммунных механизмов интраокулярного воспаления, но и к разработке методов биотерапии заболеваний сосудистого тракта и сетчатки. В обзоре проанализированы преимущества и недостатки основных экспериментальных моделей увеоретинита и ретинопатии с позиций адекватности воспроизведения заболеваний глаз у человека.

Modelling of uveoretinitis and retinopathy in animals and cell cultures was a key step to discovery of immune mechanisms of intraocular inflammation and development of methods for biotherapy of uveal and retinal diseases. In this review, the advantages and shortcomings of uveoretinitis and retinopathy models have been analyzed in terms of adequacy of human disease reproduction.

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The authors declare that there are no conflicts of interest present.