Work is devoted to research of consequences of influence of acute hypobaric hypoxia on female gametes of rats and mice. In experiment the rats of the strain HY/Y low-steady against a hypoxia removed and supported in SCBMT and a mouse strain C57BL/6Y, supported also in our Center were used. Virgin females of rats and mice for 9-16 days of the post-hypoxemic period coupled to intact males to reveal consequences of influence of the general hypobaric hypoxia on female gametes. The accounting of embryonic mortality in the uterine period of development carried out, opening females for 19-20 days of pregnancy. As a result of the conducted research the following is established. At the general mortality of embryos in the post-implantation period of development in 39,1% at females of rats and - 38,73% at females of mice, the share of mortality of the embryos, caused by influence of a sharp hypoxia, made at them 32,89% and 31,76%, respectively. Losses from among ovulated ova at a preimplantation stage at females in experience made at rats 14,3%, at mice - 26,7%. Thus, under the influence of acute hypoxia on females gametes of rats females of mice had total losses equal 47,16%, - 58,45%. It should be noted also that 6 females of rats and 4 females of mice in experience had no any implant in general. While at control animals of both types it isn’t revealed any case of their absence. It is explained, apparently, by that it, was caused by impact of a hypoxia on a female in the period of her especially sensitive stage of an ovogenesis that probably finds confirmation in wide scope of a variation of size of this indicator at females of skilled groups.