scbmtБИОМЕДИЦИНАJournal Biomed2074-59822713-0428Scientific center of biomedical technologies of Federal Medical and Biological Agencyscbmt-47Research ArticleНОВЫЕ БИОМЕДИЦИНСКИЕ ТЕХНОЛОГИИNEW BIOMEDICAL TECHNOLOGIESМикрофлюидные технологии в изучении и моделировании гематоэнцефалического барьераMicrofluidic technologies in studying and modelling the blood-brain barrierМоргунА. В.MorgunA. V.noemail@neicon.ruСалминВ. В.SalminV. V.allasalmina@mail.ruУспенскаяЮ. А.UspenskayaY. A.noemail@neicon.ruТепляшинаЕ. А.TeplyashinaE. A.noemail@neicon.ruСалминаА. Б.SalminaA. B.noemail@neicon.ruНИИ молекулярной медицины и патобиохимии ФГБОУ ВО «Красноярский государственный медицинский университет имени проф. В.Ф. Войно-Ясенецкого» Минздрава России, КрасноярскRussian Federation201625022019042233Copyright © Моргун А.В., Салмин В.В., Успенская Ю.А., Тепляшина Е.А., Салмина А.Б., 20192019Моргун А.В., Салмин В.В., Успенская Ю.А., Тепляшина Е.А., Салмина А.Б.Morgun A.V., Salmin V.V., Uspenskaya Y.A., Teplyashina E.A., Salmina A.B.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.scbmt.ru/jour/article/view/47

Разработка моделей гематоэнцефалического барьера (ГЭБ) in vitro является актуальной задачей нейробиологии и нейрофармакологии. Все большее значение приобретают модели с использованием технологии микрофлюидики, позволяющие изучать и воспроизводить ключевые события церебрального ангиогенеза, барьерогенеза, механизмы поддержания структурно-функциональной целостности ГЭБ, тестировать препараты с потенциальной нейротропной активностью. В обзоре анализируются современные достижения в разработке микрофлюидных моделей ГЭБ, а также наиболее перспективные технологические решения, обеспечивающие качественно новые возможности в создании и применении моделей in vitro .

Development of the blood-brain barrier model in vitro is one of the main points in modern Neurobiology and Neuropharmacology. Application of microfluidic approach to the blood-brain barrier modeling allows studying and reconstructing the key events in cerebral angiogenesis, barriergenesis, regulation of structural and functional integrity of the barrier, and testing the drug candidates targeting brain tissue. Here we review the current achievements in the development of blood-brain barrier microfluidic models as well as the most promising technological solutions to get novel opportunities in the development and application of these models in vitro .

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The authors declare that there are no conflicts of interest present.