scbmtБИОМЕДИЦИНАJournal Biomed2074-59822713-0428Scientific center of biomedical technologies of Federal Medical and Biological Agencyscbmt-477Research ArticleГЕНЕТИКАСравнительный анализ воздействия цитостатических препаратов на нестабильность генома Drosophila melanogasterThe comparative analysis of influence of cytostatic drugs on genome instability of Drosophila melanogasterАнтосюкО. Н.AntosyukO. N.Antosuk-olga@mail.ruМарвинА. М.MarvinA. M.noemail@neicon.ruМарвинН. А.MarvinN. A.noemail@neicon.ruУральский федеральный университет имени первого президента России Б.Н. Ельцина, ЕкатеринбургRussian Federation201421012020138391Copyright © Антосюк О.Н., Марвин А.М., Марвин Н.А., 20202020Антосюк О.Н., Марвин А.М., Марвин Н.А.Antosyuk O.N., Marvin A.M., Marvin N.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.scbmt.ru/jour/article/view/477

Морфометрический анализ крыла Drosophila melanogaster выявил различные изменения крыловых параметров при воздействии Метотрексатом, Гельданамицином и Митомицином-С, а также сходные изменения при воздействии Этопозидом и Циклофосфаном. При используемой дозе 2 мкг/кг среды повреждения типа «вырезка» на крыле наблюдались только в случае воздействия Метотрексатом. Можно предположить, что именно Метотрексат, Митомицин-С и Гельданамицин вызывают большую геномную нестабильность, судя по косвенным показателям.

Morphometric analysis of Drosophila melanogaster wings revealed various change of wing`s parameters at influence by Methotrexate, Heldanamicine and Mytomicine-C, and similar changes at influence by Etoposide and Cyclophosphane. At a used dose of 2 mkg/kg of the environment of damage like “cutting” on a wing were observed only in case of influence by the Methotrexate. It is possible to assume what exactly the Methotrexate, Mitomicine-S and Geldanamicine cause big genomic instability, judging by indirect indicators.

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The authors declare that there are no conflicts of interest present.