scbmtБИОМЕДИЦИНАJournal Biomed2074-59822713-0428Scientific center of biomedical technologies of Federal Medical and Biological Agencyscbmt-517Research ArticleМЕТОДЫ БИОМЕДИЦИНСКИХ ИССЛЕДОВАНИЙMETHODS OF BIOMEDICAL RESEARCHESРаботоспособность крыс в тесте «Вынужденное плавание с грузом» и причины её вариабельностиThe rat work capacity in forced swimming test with load and causes it variabilityЗайцеваМ. С.ZaytsevaM. S.zaiceva.mar@yandex.ruИвановД. Г.IvanovD. G.noemail@neicon.ruАлександровскаяН. В.AlexandrovskayaN. V.noemail@neicon.ruФГУП «НЦ «Сигнал»Russian Federation201522012020143042Copyright © Зайцева М.С., Иванов Д.Г., Александровская Н.В., 20202020Зайцева М.С., Иванов Д.Г., Александровская Н.В.Zaytseva M.S., Ivanov D.G., Alexandrovskaya N.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.scbmt.ru/jour/article/view/517

Исследовано влияние способа введения, массы тела животных и атмосферного давления на динамику показателя работоспособности крыс при плавании с грузом 10% от массы тела. Работоспособность тестировали у животных на первые, восьмые, пятнадцатые и двадцать вторые сутки внутрижелудочного и внутримышечного введения дистиллированной воды. Динамика длительности плавания крыс при обоих способах введения характеризовалась увеличением значений показателя на восьмые, пятнадцатые и двадцать вторые сутки по сравнению с результатами первого тестирования. На пятнадцатые сутки эксперимента длительность плавания животных, на которых применялось внутрижелудочное введение, была больше, чем при внутримышечном введении. Показатель длительности плавания животных имел обратную регрессионную зависимость от массы тела и относительной массы эпидидимального жира. Атмосферное давление не оказывало влияния на среднегрупповые значения длительности плавания животных. Имелись животные с индивидуальной чувствительностью к уровню атмосферного давления, количество которых было больше в группе с внутримышечным введением.

The drug administration rout, body mass and atmospheric pressure effects on the rat work capacity in forced swimming test with 10% from body mass load were investigated. The rat work capacity was tested at the 1, 8, 15 and 22-nd days of intragastral or intramuscular distilled water administration. At the 8, 15 and 22-nd experimental days the rat swimming time was increased in comparison with 1-st day test results. At the 15-th day work capacity in rat group with intragastral rout was greater than in the group with intramuscular injection. The rat swimming time had inverted correlation with body mass and relative epididymidal fat mass. Atmospheric pressure had no effect on the mean swimming time in rats groups, but rats with individual sensibility to atmospheric pressure was detected. The individual sensibility of rat to atmospheric pressure was greater in rat group with intramuscular injection than in group with intragastral administration rout.

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