scbmtБИОМЕДИЦИНАJournal Biomed2074-59822713-0428Scientific center of biomedical technologies of Federal Medical and Biological Agencyscbmt-522Research ArticleДОКЛИНИЧЕСКИЕ ИССЛЕДОВАНИЯNON-CLINICAL RESEARCHESЭнтеральное введение трибутирина как компонента нутритивной поддержки в коррекции нарушений электрической активности тонкой кишки при экспериментальной эндотоксемииEnteral administration of tributyrin as an element of nutritional support in the treatment of disruption of the intestinal electrical activity during experimental endotoxemiaКисляковаЕ. А.KislyakovaE. A.kisliakovakatia@mail.ruТропскаяН. С.TropskayaN. S.noemail@neicon.ruПоповаТ. С.PopovaT. S.noemail@neicon.ruГБУЗ г. Москвы «Научно-исследовательский институт скорой помощи им. Н.В. Склифосовского Департамента здравоохранения г. Москвы»Russian Federation201522012020147783Copyright © Кислякова Е.А., Тропская Н.С., Попова Т.С., 20202020Кислякова Е.А., Тропская Н.С., Попова Т.С.Kislyakova E.A., Tropskaya N.S., Popova T.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.scbmt.ru/jour/article/view/522

Исследована электрическая активность тонкой кишки крыс, которым внутривенно вводили 200 мкг/кг липополисахарида E. coli . Показано, что нарушения в генерации мигрирующего миоэлектрического комплекса наблюдаются на протяжении 96-ти ч после введения липополисахарида. Применение энтерального введения трибутирина укорачивало общие сроки восстановления мигрирующего миоэлектрического комплекса до 48-ми ч.

We investigated the electrical activity of the small intestine in rats intravenously administered 200 µg/kg of lipopolysaccharide E. coli . It has been shown that disturbances in the generation of migrating myoelectric complex were observed during the 96-hours after lipopolysaccharide administration. Enteral administration of tributyrin shortened overall recovery times migrating myoelectric complex to 48 hours.

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The authors declare that there are no conflicts of interest present.