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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">scbmt</journal-id><journal-title-group><journal-title xml:lang="ru">БИОМЕДИЦИНА</journal-title><trans-title-group xml:lang="en"><trans-title>Journal Biomed</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2074-5982</issn><issn pub-type="epub">2713-0428</issn><publisher><publisher-name>Scientific center of biomedical technologies of Federal Medical and Biological Agency</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">scbmt-606</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ ИССЛЕДОВАНИЯ</subject></subj-group></article-categories><title-group><article-title>Гистопатоморфологические изменения кишечника при обтурационной опухолевой толстокишечной непроходимости</article-title><trans-title-group xml:lang="en"><trans-title>Histopathomorphological changes in bowel obstructive neoplastic colonic obstruction</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ачкасов</surname><given-names>Е. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Achkasov</surname><given-names>E. E.</given-names></name></name-alternatives><email xlink:type="simple">2215.g23@rambler.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Алекперов</surname><given-names>С. Ф.</given-names></name><name name-style="western" xml:lang="en"><surname>Alekperov</surname><given-names>S. F.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мельников</surname><given-names>П. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Melnikov</surname><given-names>P. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Колышев</surname><given-names>И. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Kolyshev</surname><given-names>I. Yu.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Калачёв</surname><given-names>О. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kalachyov</surname><given-names>O. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Орехов</surname><given-names>О. О.</given-names></name><name name-style="western" xml:lang="en"><surname>Orekhov</surname><given-names>O. O.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Каннер</surname><given-names>Д. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Kanner</surname><given-names>D. Yu.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>ГБОУ ВПО Первый МГМУ им. И.М. Сеченова Минздравсоцразвития РФ, Москва</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2012</year></pub-date><pub-date pub-type="epub"><day>13</day><month>02</month><year>2020</year></pub-date><volume>1</volume><issue>4</issue><fpage>113</fpage><lpage>123</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Ачкасов Е.Е., Алекперов С.Ф., Мельников П.В., Колышев И.Ю., Калачёв О.А., Орехов О.О., Каннер Д.Ю., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Ачкасов Е.Е., Алекперов С.Ф., Мельников П.В., Колышев И.Ю., Калачёв О.А., Орехов О.О., Каннер Д.Ю.</copyright-holder><copyright-holder xml:lang="en">Achkasov E.E., Alekperov S.F., Melnikov P.V., Kolyshev I.Y., Kalachyov O.A., Orekhov O.O., Kanner D.Y.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.scbmt.ru/jour/article/view/606">https://journal.scbmt.ru/jour/article/view/606</self-uri><abstract><p>Изучены особенности морфологических изменений в стенке ободочной и тонкой кишки у 26 боль- ных с обтурационной опухолевой толстокишечной непроходимостью (ОТКН). Выявлена динамика в развитии морфологических изменений кишечной стенки в зависимости от степени компенсации ОТКН, которая заключалась в прогрессирующем отёке, нарушении кровообращения с внутрисосудистыми предтромботическими изменениями и острой воспалительной реакции. Подобные острые изменения в кишечной стенке происходили на фоне хронических морфологических изменений, особенно у больных пожилого и старческого возраста, которые могут способствовать нарушению всасывательной функции кишки. На основании полученных данных можно сделать вывод, что следует воздерживаться от вы- полнения первичных межкишечных соустий на высоте ОТКН, а выполнение радикальных операций с формированием межкишечных анастомозов следует осуществлять не ранее, чем через 3-4 недели после устранения кишечной непроходимости.</p></abstract><trans-abstract xml:lang="en"><p>Particular morphological changes in the wall of colon and small intestine have been studied in 26 patients with obturation tumorous intestine obstruction (OTIO). The dynamics in the development of morphological changes of intestinal wall were detected according to the rate of compensation of the OTIO, which lied in progressing edema, blood circulation disturbance with vessels prethrombus changes and acute inflammatory reaction. Such acute changes in the intestine wall occurred against a background of chronic morphologic changes, especially by the patients of elderly and senile age, which can contribute to the disturbance of sucking intestine function. On the base of received data can be made a conclusion about inadmissibility of realization of primary enterostomies on the height of OTIO, and realization of radical surgeries with forming interintestinal anastomosis should be done not earlier than in 3-4 weeks after elimination of ileus.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>гистопатоморфология</kwd><kwd>колоректальный рак</kwd><kwd>острая толстокишечная непроходи- мость</kwd><kwd>ободочная кишка</kwd><kwd>тонкая кишка</kwd><kwd>острая воспалительная реакция</kwd><kwd>внутрисосудистые предтром- ботические изменения</kwd><kwd>морфологические изменения</kwd><kwd>всасывательная функция кишки</kwd><kwd>межкишечные анастомозы</kwd><kwd>histopathomorphology</kwd><kwd>colorectal cancer</kwd><kwd>acute colon impossibility</kwd><kwd>colon</kwd><kwd>small intestine</kwd><kwd>acute inflammatory reaction</kwd><kwd>vessels prethrombus changes</kwd><kwd>morphological changes</kwd><kwd>absorptive intestine function</kwd><kwd>interintestinal anastomosis</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Бабков О.В. и соавт. 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