scbmtБИОМЕДИЦИНАJournal Biomed2074-59822713-0428Scientific center of biomedical technologies of Federal Medical and Biological Agencyscbmt-63Research ArticleМЕТОДЫ БИОМЕДИЦИНСКИХ ИССЛЕДОВАНИЙMETHODS OF BIOMEDICAL RESEARCHESАдаптационные изменения у крыс при ежедневном выполнении физической нагрузки в методике «Бег на тредбане»Adaptive changes in rats under everyday physical load in «The run on treadmill» methodИвановД. Г.IvanovD. G.dg1983@myrambler.ruАлександровскаяН. В.AlexandrovskayaN. V.noemail@neicon.ruАфонькинаЕ. А.AfonkinaE. A.noemail@neicon.ruЕрошкинП. В.EroshkinP. V.noemail@neicon.ruСеменовА. Н.SemenovA. N.noemail@neicon.ruБусыгинД. В.BusiiginD. V.noemail@neicon.ruФГУП «НЦ «Сигнал»Россия20172602201902422Copyright © Иванов Д.Г., Александровская Н.В., Афонькина Е.А., Ерошкин П.В., Семенов А.Н., Бусыгин Д.В., 20192019Иванов Д.Г., Александровская Н.В., Афонькина Е.А., Ерошкин П.В., Семенов А.Н., Бусыгин Д.В.Ivanov D.G., Alexandrovskaya N.V., Afonkina E.A., Eroshkin P.V., Semenov A.N., Busiigin D.V.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.scbmt.ru/jour/article/view/63

Изучались адаптационные изменения у крыс при ежедневном выполнении в течение четырех недель тренировочной (бег на тредбане 20 мин со скоростью 15 м/мин и углом подъема 15° 4 дня в неделю) и тестовой (бег до отказа с ускорением 0,6 м/мин2, начальной скоростью 12 м/мин и углом подъема 15° 1 день в неделю) физических нагрузок. По результатам определения динамики уровня глюкозы и лактата в крови тестовая нагрузка соответствовала нагрузкам аэробной околомаксимальной зоны мощности, тренировочная - нагрузкам аэробной средней или низкой зон мощности. Адаптация к нагрузке в виде увеличения длительности бега до отказа была связана с гипертрофией мышц, увеличением числа эритроцитов в крови, уменьшением среднего объёма эритроцита и ширины распределения эритроцитов по объёму, снижением числа тромбоцитов, уменьшением числа сердечных сокращений и систолического давления. Физическая нагрузка не приводила к увеличению глюкотолерантности, изменению уровня глюкозы в крови, содержания гликогена в мышце, не влияла на массу эпидидимального жира у крыс. Состояния утомления, анализируемого по массе левого надпочечника, тимуса и селезёнки, уровню кортизола и мочевины в крови, активности аминотрансфераз и содержанию белка в печени, содержанию белка, молочной кислоты в мышцах, у крыс при выполнении физической нагрузки обнаружено не было.

The adaptive changes in rats under 4 week’s everyday training (4 days/week) and test (1 days/week) physical exercise on treadmill was investigated. The training exercise was consisted of 20 minutes run with velocity 15 m/min and incline 15°. The test exercise was 20-30 minutes run until exhaustion with acceleration 0,6 m/min2, initial velocity 12 m/min and incline 15°. The test exercise was corresponded to submaximal intensity aerobic capacity zone, and training exercise was related to medium or low intensity aerobic capacity zone by results of measurements glucose and lactate blood level. The adaptation to load were associated with the muscle hypertrophy, erythrocytes increasing, mean corpuscles volume, red cell width distribution and platelets decreasing, reduction heart rate and values of systolic pressure. The physical exercise did not influence on glucose tolerance and glucose blood level, containing glucose and glycogen in gastrocnemius muscle, wet weight of epididymal fat in rats. After 4 weeks physical load did not influence on left adrenal, thymus and spleen weights, blood level of cortisol, thyroxin, triiodothyronine and urea, liver protein and amino transferases activity, muscle lactate, protein and aspartate amino transferase activity. Therefore we suggested that physical exercise did not produce fatigue in rat.

крысатредбанадаптацияфизическая работоспособностьrattreadmilladaptationphysical exerciseReferencesЗайцева М.С., Иванов Д.Г., Александровская Н.В. Работоспособность крыс в тесте «Плавание с грузом» и причины ее вариабельности // Биомедицина. 2015. № 4. С. 30-42.Зайцева М.С., Иванов Д.Г., Александровская Н.В. Работоспособность крыс в тесте «Плавание с грузом» и причины ее вариабельности // Биомедицина. 2015. № 4. С. 30-42.Каркищенко Н.Н. Альтернативы биомедицины. Т. 1. Основы биомедицины и фармакомоделирования. - М.: Изд-во ВПК, 2007. - 320 с.Каркищенко Н.Н. Альтернативы биомедицины. Т. 1. Основы биомедицины и фармакомоделирования. - М.: Изд-во ВПК, 2007. - 320 с.Соловьева Г.А. Зайцева Н.Н., Телепнёва В.И. Углеводы и липиды // Практикум по биохимии. - М.: Изд-во Московского университета. 1989. С. 5-78.Соловьева Г.А. Зайцева Н.Н., Телепнёва В.И. Углеводы и липиды // Практикум по биохимии. - М.: Изд-во Московского университета. 1989. С. 5-78.Ткаченко А.В. Метаболические процессы в сердце и печени крыс при экспериментальной гипокинезии и их коррекция фитосиропом «Валеотон» // Вестник Харьковского национального университета. Серия: Биология. 2011. В. 14. № 971. С. 177-184.Ткаченко А.В. Метаболические процессы в сердце и печени крыс при экспериментальной гипокинезии и их коррекция фитосиропом «Валеотон» // Вестник Харьковского национального университета. Серия: Биология. 2011. В. 14. № 971. С. 177-184.Фомин Н.А., Вавилов Ю.Н. Физиологические основы двигательной активности. М.: Физкультура и спорт, 1991. - 224 с.Фомин Н.А., Вавилов Ю.Н. Физиологические основы двигательной активности. М.: Физкультура и спорт, 1991. - 224 с.Ament W., Verkerke G.J. Exercise and Fatigue // Sports Med. 2009. V. 39. No. 5. P. 389-422.Ament W., Verkerke G.J. Exercise and Fatigue // Sports Med. 2009. V. 39. No. 5. P. 389-422.Baptista S., Piloto N., Reis F., Teixeira-de-Lemos E., Garrido A.P., Dias A., Lourenco M., Palmeiro A., Ferrer-Antunes C., Teixeira F. Treadmill running and swimming imposes distinct cardiovascular physiological adaptations in the rat: focus on serotonergic and sympathetic nervous systems modulation // Acta Physiologica Hungarica. 2008. doi: 10.1556/APhysiol.2008.0002.Baptista S., Piloto N., Reis F., Teixeira-de-Lemos E., Garrido A.P., Dias A., Lourenco M., Palmeiro A., Ferrer-Antunes C., Teixeira F. Treadmill running and swimming imposes distinct cardiovascular physiological adaptations in the rat: focus on serotonergic and sympathetic nervous systems modulation // Acta Physiologica Hungarica. 2008. doi: 10.1556/APhysiol.2008.0002.Billat V.L. Sirvent P., Py G., Koralsztein J.P. Mercie J. The concept of maximal lactate steady state a bridge between biochemistry, physiology and sport science // Sports Med. 2003. V. 33. No. 6. P. 407-426.Billat V.L. Sirvent P., Py G., Koralsztein J.P. Mercie J. The concept of maximal lactate steady state a bridge between biochemistry, physiology and sport science // Sports Med. 2003. V. 33. No. 6. P. 407-426.Brooks G.A., White T.P. Determination of metabolic and heart rate responses of rats to treadmill exercise // J. Appl. Physiol.: respirat. environ. exercise physiol. 1978. V. 45. No. 6. P. 1009-1015.Brooks G.A., White T.P. Determination of metabolic and heart rate responses of rats to treadmill exercise // J. Appl. Physiol.: respirat. environ. exercise physiol. 1978. V. 45. No. 6. P. 1009-1015.Chen Z.P., Stephens T.J., Murthy S., Canny B.J., Hargreaves M., Witters L.A., Kemp B.E., McConell G.K. Effect of exercise intensity on skeletal muscle AMPK signaling in humans // Diabetes. 2003. V. 52. P. 2205-2212.Chen Z.P., Stephens T.J., Murthy S., Canny B.J., Hargreaves M., Witters L.A., Kemp B.E., McConell G.K. Effect of exercise intensity on skeletal muscle AMPK signaling in humans // Diabetes. 2003. V. 52. P. 2205-2212.Copp S.W., Hirai D.M., Musch T.I., Poole D.C. Critical speed in the rat: implications for hindlimb muscle blood flow distribution and fibre recruitment // J. Physiol. 2010. V. 588. No. 24. P. 5077-5087.Copp S.W., Hirai D.M., Musch T.I., Poole D.C. Critical speed in the rat: implications for hindlimb muscle blood flow distribution and fibre recruitment // J. Physiol. 2010. V. 588. No. 24. P. 5077-5087.Dantas E.M., Pimentel E.B., Gonçalves C.P., Lunz W., Rodrigues S.L., Mill J.G. Effects of chronic treadmill training on body mass gain and visceral fat accumulation in overfed rats // Brazilian J. of medical and biological research. 2010. V. 43. P. 515-521.Dantas E.M., Pimentel E.B., Gonçalves C.P., Lunz W., Rodrigues S.L., Mill J.G. Effects of chronic treadmill training on body mass gain and visceral fat accumulation in overfed rats // Brazilian J. of medical and biological research. 2010. V. 43. P. 515-521.Delp M.D., Duan C. Composition and size of type I, IIA, IID/X, and IIB fibers and citrate synthase activity of rat muscle // J. Appl. Physiol. 1996. V. 80. P. 261-270.Delp M.D., Duan C. Composition and size of type I, IIA, IID/X, and IIB fibers and citrate synthase activity of rat muscle // J. Appl. Physiol. 1996. V. 80. P. 261-270.Díaz-Herreral P., Garcia-Castellano J.M., Torres A., Morcuende J.A., Calbet J.A.L., Sarrat R. Effect of high-intensity running in rectus femoris muscle fiber in rats // Journal of Orthopaedic research. 2001. V. 19. P. 229-232.Díaz-Herreral P., Garcia-Castellano J.M., Torres A., Morcuende J.A., Calbet J.A.L., Sarrat R. Effect of high-intensity running in rectus femoris muscle fiber in rats // Journal of Orthopaedic research. 2001. V. 19. P. 229-232.Díaz-Herreral P., Torres A., Morcuende J.A., Garcia-Castellano J.M., Calbet J.A.L., Sarrat R. Effect of endurance running on cardiac and skeletal muscle in rats // Histol. Histopathol. 2001. V. 16. P. 29-35.Díaz-Herreral P., Torres A., Morcuende J.A., Garcia-Castellano J.M., Calbet J.A.L., Sarrat R. Effect of endurance running on cardiac and skeletal muscle in rats // Histol. Histopathol. 2001. V. 16. P. 29-35.Guerreiro L.F., Pereira A.A., Martins C.N., Wally C., Gonçalves C.A.N. Swimming Physical Training in Rats: Cardiovascular Adaptation to Exercise Training Protocols at Different Intensities // JEPonline. 2015. V. 18. No. 1. P. 1-12.Guerreiro L.F., Pereira A.A., Martins C.N., Wally C., Gonçalves C.A.N. Swimming Physical Training in Rats: Cardiovascular Adaptation to Exercise Training Protocols at Different Intensities // JEPonline. 2015. V. 18. No. 1. P. 1-12.Haram P.M., Kemi O.J., Lee S.J., Bendheim M.O., Al-Share Q.Y., Waldum H.L., Gilligan L.J., Koch L.G., Britton S.L., Najjar S.M., Wisloff U. Aerobic interval training vs. continuous moderate exercise in the metabolic syndrome of rats artificially selected for low aerobic capacity // Cardiovascular research. 2009. V. 81. P. 723-732.Haram P.M., Kemi O.J., Lee S.J., Bendheim M.O., Al-Share Q.Y., Waldum H.L., Gilligan L.J., Koch L.G., Britton S.L., Najjar S.M., Wisloff U. Aerobic interval training vs. continuous moderate exercise in the metabolic syndrome of rats artificially selected for low aerobic capacity // Cardiovascular research. 2009. V. 81. P. 723-732.Jones A.M., Doust J.H. The validity of the lactate minimum test for determination of the maximal lactate steady state // Medicine&Science in Sports&Exercise. 1998. V. 30. No. 8. P. 1304-1313.Jones A.M., Doust J.H. The validity of the lactate minimum test for determination of the maximal lactate steady state // Medicine&Science in Sports&Exercise. 1998. V. 30. No. 8. P. 1304-1313.Jones A.M., Vanhatalo A., Burnley M., Morton R.H., Poole D.C. Critical Power: Implications for Deter-mination of VO2max and Exercise Tolerance // Med. sci. sports exerc. 2010. V. 42. No. 10. P. 1876-1890.Jones A.M., Vanhatalo A., Burnley M., Morton R.H., Poole D.C. Critical Power: Implications for Deter-mination of VO2max and Exercise Tolerance // Med. sci. sports exerc. 2010. V. 42. No. 10. P. 1876-1890.Krege J.H., Hodgin J.B., Hagaman J.R., Smithies O. A Noninvasive Computerized Tail-Cuff System for Measuring Blood Pressure in Mice // Hypertension. 1995. V. 25. P. 1111-1115.Krege J.H., Hodgin J.B., Hagaman J.R., Smithies O. A Noninvasive Computerized Tail-Cuff System for Measuring Blood Pressure in Mice // Hypertension. 1995. V. 25. P. 1111-1115.Manchado-Gobatto F.B., Gobatto C.A., Contarteze R.L., Papoti M., Araujo G.G., Mello M.A.R. Determination of Critical Velocity and Anaerobic Capacity of Running Rats // JEPonline. 2010; 13(4):40-49.Manchado-Gobatto F.B., Gobatto C.A., Contarteze R.L., Papoti M., Araujo G.G., Mello M.A.R. Determination of Critical Velocity and Anaerobic Capacity of Running Rats // JEPonline. 2010; 13(4):40-49.Monteiro M.F., Filho D.C.S. Physical exercise and blood pressure control // Rev. bras. med. esporte. 2004. V. 10. No. 6. P. 517-519.Monteiro M.F., Filho D.C.S. Physical exercise and blood pressure control // Rev. bras. med. esporte. 2004. V. 10. No. 6. P. 517-519.Moraska A., Deak T., Spencer R.L., Roth D., Fleshner M. Treadmill running produces both positive and negative physiological adaptations in Sprague-Dawley rats // Am. J. Physiol. regulatory integrative comp. physiol. 2000. V. 279. P. R1321-R1329.Moraska A., Deak T., Spencer R.L., Roth D., Fleshner M. Treadmill running produces both positive and negative physiological adaptations in Sprague-Dawley rats // Am. J. Physiol. regulatory integrative comp. physiol. 2000. V. 279. P. R1321-R1329.Nakatani A., Han D.H., Hansen P.A., Nolte L.A., Host H.H., Hickner R.C., Holloszy J.O. Effect of endurance exercise training on muscle glycogen supercompensation in rats // J. Appl. Physiol. 1997. V. 82 (2). P. 711-715.Nakatani A., Han D.H., Hansen P.A., Nolte L.A., Host H.H., Hickner R.C., Holloszy J.O. Effect of endurance exercise training on muscle glycogen supercompensation in rats // J. Appl. Physiol. 1997. V. 82 (2). P. 711-715.Veras-Silva A.S., Mattos K.C., Gava N.S., Brum P.C., Negrao C.E., Krieger E.M. Low-intensity exercise training decreases cardiac output and hypertension in spontaneously hypertensive rats // Am. J. Physiol. heart circ. physiol. 1997. V. 273. No. 42. P. H2627-H2631.Veras-Silva A.S., Mattos K.C., Gava N.S., Brum P.C., Negrao C.E., Krieger E.M. Low-intensity exercise training decreases cardiac output and hypertension in spontaneously hypertensive rats // Am. J. Physiol. heart circ. physiol. 1997. V. 273. No. 42. P. H2627-H2631.Voltarelli F.A., Gobatto C.A., Mello M.A.R. Determination of anaerobic threshold in rats using the lactate minimum test // Braz. J. med. biol. res. 2002. V. 35. No. 11. P. 1389-1394.Voltarelli F.A., Gobatto C.A., Mello M.A.R. Determination of anaerobic threshold in rats using the lactate minimum test // Braz. J. med. biol. res. 2002. V. 35. No. 11. P. 1389-1394.Zendzian-Piotrowska M., Gorski J. Metabolic adaptation to daily exercise of moderate intensity to exhaustion in the rat // Eur. J. Appl. physiol. 1993. V. 67. P. 77-82.Zendzian-Piotrowska M., Gorski J. Metabolic adaptation to daily exercise of moderate intensity to exhaustion in the rat // Eur. J. Appl. physiol. 1993. V. 67. P. 77-82.Zajceva M.S., Ivanov D.G., Aleksandrovskaja N.V. Rabotosposobnost' krys v teste «Plavanie s gruzom» i prichiny ee variabel'nosti // Biomedicina. 2015. № 4. S. 30-42.Zajceva M.S., Ivanov D.G., Aleksandrovskaja N.V. Rabotosposobnost' krys v teste «Plavanie s gruzom» i prichiny ee variabel'nosti // Biomedicina. 2015. № 4. S. 30-42.Karkischenko N.N. Al'ternativy biomediciny. T. 1. Osnovy biomediciny i farmakomodelirovanija. - M.: Izd-vo VPK, 2007. - 320 s.Karkischenko N.N. Al'ternativy biomediciny. T. 1. Osnovy biomediciny i farmakomodelirovanija. - M.: Izd-vo VPK, 2007. - 320 s.Solov'eva G.A. Zajceva N.N., Telepnjova V.I. Uglevody i lipidy // Praktikum po biohimii. - M.: Izd-vo Moskovskogo universiteta. 1989. S. 5-78.Solov'eva G.A. Zajceva N.N., Telepnjova V.I. Uglevody i lipidy // Praktikum po biohimii. - M.: Izd-vo Moskovskogo universiteta. 1989. S. 5-78.Tkachenko A.V. Metabolicheskie processy v serdce i pecheni krys pri jeksperimental'noj gipokinezii i ih korrekcija fitosiropom «Valeoton» // Vestnik Har'kovskogo nacional'nogo universiteta. Serija: Biologija. 2011. V. 14. № 971. S. 177-184.Tkachenko A.V. Metabolicheskie processy v serdce i pecheni krys pri jeksperimental'noj gipokinezii i ih korrekcija fitosiropom «Valeoton» // Vestnik Har'kovskogo nacional'nogo universiteta. Serija: Biologija. 2011. V. 14. № 971. S. 177-184.Fomin N.A., Vavilov Ju.N. Fiziologicheskie osnovy dvigatel'noj aktivnosti. M.: Fizkul'tura i sport, 1991. - 224 s.Fomin N.A., Vavilov Ju.N. Fiziologicheskie osnovy dvigatel'noj aktivnosti. M.: Fizkul'tura i sport, 1991. - 224 s.Ament W., Verkerke G.J. Exercise and Fatigue // Sports Med. 2009. V. 39. No. 5. P. 389-422.Ament W., Verkerke G.J. Exercise and Fatigue // Sports Med. 2009. V. 39. No. 5. P. 389-422.Baptista S., Piloto N., Reis F., Teixeira-de-Lemos E., Garrido A.P., Dias A., Lourenco M., Palmeiro A., Ferrer-Antunes C., Teixeira F. Treadmill running and swimming imposes distinct cardiovascular physiological adaptations in the rat: focus on serotonergic and sympathetic nervous systems modulation // Acta Physiologica Hungarica. 2008. doi: 10.1556/APhysiol.2008.0002.Baptista S., Piloto N., Reis F., Teixeira-de-Lemos E., Garrido A.P., Dias A., Lourenco M., Palmeiro A., Ferrer-Antunes C., Teixeira F. Treadmill running and swimming imposes distinct cardiovascular physiological adaptations in the rat: focus on serotonergic and sympathetic nervous systems modulation // Acta Physiologica Hungarica. 2008. doi: 10.1556/APhysiol.2008.0002.Billat V.L. Sirvent P., Py G., Koralsztein J.P. Mercie J. The concept of maximal lactate steady state a bridge between biochemistry, physiology and sport science // Sports Med. 2003. V. 33. No. 6. P. 407-426.Billat V.L. Sirvent P., Py G., Koralsztein J.P. Mercie J. The concept of maximal lactate steady state a bridge between biochemistry, physiology and sport science // Sports Med. 2003. V. 33. No. 6. P. 407-426.Brooks G.A., White T.P. Determination of metabolic and heart rate responses of rats to treadmill exercise // J. Appl. Physiol.: respirat. environ. exercise physiol. 1978. V.45. No. 6. P. 1009-1015.Brooks G.A., White T.P. Determination of metabolic and heart rate responses of rats to treadmill exercise // J. Appl. Physiol.: respirat. environ. exercise physiol. 1978. V.45. No. 6. P. 1009-1015.Chen Z.P., Stephens T.J., Murthy S., Canny B.J., Hargreaves M., Witters L.A., Kemp B.E., McConell G.K. Effect of exercise intensity on skeletal muscle AMPK signaling in humans // Diabetes. 2003. V. 52. P. 2205-2212.Chen Z.P., Stephens T.J., Murthy S., Canny B.J., Hargreaves M., Witters L.A., Kemp B.E., McConell G.K. Effect of exercise intensity on skeletal muscle AMPK signaling in humans // Diabetes. 2003. V. 52. P. 2205-2212.Copp S.W., Hirai D.M., Musch T.I., Poole D.C. Critical speed in the rat: implications for hindlimb muscle blood flow distribution and fibre recruitment // J. Physiol. 2010. V. 588. No. 24. P. 5077-5087.Copp S.W., Hirai D.M., Musch T.I., Poole D.C. Critical speed in the rat: implications for hindlimb muscle blood flow distribution and fibre recruitment // J. Physiol. 2010. V. 588. No. 24. P. 5077-5087.Dantas E.M., Pimentel E.B., Gonçalves C.P., Lunz W., Rodrigues S.L., Mill J.G. Effects of chronic treadmill training on body mass gain and visceral fat accumulation in overfed rats // Brazilian J. of medical and biological research. 2010. V. 43. P. 515-521.Dantas E.M., Pimentel E.B., Gonçalves C.P., Lunz W., Rodrigues S.L., Mill J.G. Effects of chronic treadmill training on body mass gain and visceral fat accumulation in overfed rats // Brazilian J. of medical and biological research. 2010. V. 43. P. 515-521.Delp M.D., Duan C. Composition and size of type I, IIA, IID/X, and IIB fibers and citrate synthase activity of rat muscle // J. Appl. Physiol. 1996. V. 80. P. 261-270.Delp M.D., Duan C. Composition and size of type I, IIA, IID/X, and IIB fibers and citrate synthase activity of rat muscle // J. Appl. Physiol. 1996. V. 80. P. 261-270.Díaz-Herreral P., Garcia-Castellano J.M., Torres A., Morcuende J.A., Calbet J.A.L., Sarrat R. Effect of high-intensity running in rectus femoris muscle fiber in rats // Journal of Orthopaedic research. 2001. V. 19. P. 229-232.Díaz-Herreral P., Garcia-Castellano J.M., Torres A., Morcuende J.A., Calbet J.A.L., Sarrat R. Effect of high-intensity running in rectus femoris muscle fiber in rats // Journal of Orthopaedic research. 2001. V. 19. P. 229-232.Díaz-Herreral P., Torres A., Morcuende J.A., Garcia-Castellano J.M., Calbet J.A.L., Sarrat R. Effect of endurance running on cardiac and skeletal muscle in rats // Histol. Histopathol. 2001. V. 16. P. 29-35.Díaz-Herreral P., Torres A., Morcuende J.A., Garcia-Castellano J.M., Calbet J.A.L., Sarrat R. Effect of endurance running on cardiac and skeletal muscle in rats // Histol. Histopathol. 2001. V. 16. P. 29-35.Guerreiro L.F., Pereira A.A., Martins C.N., Wally C., Gonçalves C.A.N. Swimming Physical Training in Rats: Cardiovascular Adaptation to Exercise Training Protocols at Different Intensities // JEPonline. 2015. V. 18. No. 1. P. 1-12.Guerreiro L.F., Pereira A.A., Martins C.N., Wally C., Gonçalves C.A.N. Swimming Physical Training in Rats: Cardiovascular Adaptation to Exercise Training Protocols at Different Intensities // JEPonline. 2015. V. 18. No. 1. P. 1-12.Haram P.M., Kemi O.J., Lee S.J., Bendheim M.O., Al-Share Q.Y., Waldum H.L., Gilligan L.J., Koch L.G., Britton S.L., Najjar S.M., Wisloff U. Aerobic interval training vs. continuous moderate exercise in the metabolic syndrome of rats artificially selected for low aerobic capacity // Cardiovascular research. 2009. V. 81. P. 723-732.Haram P.M., Kemi O.J., Lee S.J., Bendheim M.O., Al-Share Q.Y., Waldum H.L., Gilligan L.J., Koch L.G., Britton S.L., Najjar S.M., Wisloff U. Aerobic interval training vs. continuous moderate exercise in the metabolic syndrome of rats artificially selected for low aerobic capacity // Cardiovascular research. 2009. V. 81. P. 723-732.Jones A.M., Doust J.H. The validity of the lactate minimum test for determination of the maximal lactate steady state // Medicine&Science in Sports&Exercise. 1998. V. 30. No. 8. P. 1304-1313.Jones A.M., Doust J.H. The validity of the lactate minimum test for determination of the maximal lactate steady state // Medicine&Science in Sports&Exercise. 1998. V. 30. No. 8. P. 1304-1313.Jones A.M., Vanhatalo A., Burnley M., Morton R.H., Poole D.C. Critical Power: Implications for Deter-mination of VO2max and Exercise Tolerance // Med. sci. sports exerc. 2010. V. 42. No. 10. P. 1876-1890.Jones A.M., Vanhatalo A., Burnley M., Morton R.H., Poole D.C. Critical Power: Implications for Deter-mination of VO2max and Exercise Tolerance // Med. sci. sports exerc. 2010. V. 42. No. 10. P. 1876-1890.Krege J.H., Hodgin J.B., Hagaman J.R., Smithies O. A Noninvasive Computerized Tail-Cuff System for Measuring Blood Pressure in Mice // Hypertension. 1995. V. 25. P. 1111-1115.Krege J.H., Hodgin J.B., Hagaman J.R., Smithies O. A Noninvasive Computerized Tail-Cuff System for Measuring Blood Pressure in Mice // Hypertension. 1995. V. 25. P. 1111-1115.Manchado-Gobatto F.B., Gobatto C.A., Contarteze R.L., Papoti M., Araujo G.G., Mello M.A.R. Determination of Critical Velocity and Anaerobic Capacity of Running Rats // JEPonline. 2010; 13(4):40-49.Manchado-Gobatto F.B., Gobatto C.A., Contarteze R.L., Papoti M., Araujo G.G., Mello M.A.R. Determination of Critical Velocity and Anaerobic Capacity of Running Rats // JEPonline. 2010; 13(4):40-49.Monteiro M.F., Filho D.C.S. Physical exercise and blood pressure control // Rev. bras. med. esporte. 2004. V. 10. No. 6. P. 517-519.Monteiro M.F., Filho D.C.S. Physical exercise and blood pressure control // Rev. bras. med. esporte. 2004. V. 10. No. 6. P. 517-519.Moraska A., Deak T., Spencer R.L., Roth D., Fleshner M. Treadmill running produces both positive and negative physiological adaptations in Sprague-Dawley rats // Am. J. Physiol. regulatory integrative comp. physiol. 2000. V. 279. P. R1321-R1329.Moraska A., Deak T., Spencer R.L., Roth D., Fleshner M. Treadmill running produces both positive and negative physiological adaptations in Sprague-Dawley rats // Am. J. Physiol. regulatory integrative comp. physiol. 2000. V. 279. P. R1321-R1329.Nakatani A., Han D.H., Hansen P.A., Nolte L.A., Host H.H., Hickner R.C., Holloszy J.O. Effect of endurance exercise training on muscle glycogen supercompensation in rats // J. Appl. Physiol. 1997. V. 82 (2). P. 711-715.Nakatani A., Han D.H., Hansen P.A., Nolte L.A., Host H.H., Hickner R.C., Holloszy J.O. Effect of endurance exercise training on muscle glycogen supercompensation in rats // J. Appl. Physiol. 1997. V. 82 (2). P. 711-715.Veras-Silva A.S., Mattos K.C., Gava N.S., Brum P.C., Negrao C.E., Krieger E.M. Low-intensity exercise training decreases cardiac output and hypertension in spontaneously hypertensive rats // Am. J. Physiol. heart circ. physiol. 1997. V. 273. No. 42. P. H2627-H2631.Veras-Silva A.S., Mattos K.C., Gava N.S., Brum P.C., Negrao C.E., Krieger E.M. Low-intensity exercise training decreases cardiac output and hypertension in spontaneously hypertensive rats // Am. J. Physiol. heart circ. physiol. 1997. V. 273. No. 42. P. H2627-H2631.Voltarelli F.A., Gobatto C.A., Mello M.A.R. Determination of anaerobic threshold in rats using the lactate minimum test // Braz. J. med. biol. res. 2002. V. 35. No. 11. P. 1389-1394.Voltarelli F.A., Gobatto C.A., Mello M.A.R. Determination of anaerobic threshold in rats using the lactate minimum test // Braz. J. med. biol. res. 2002. V. 35. No. 11. P. 1389-1394.Zendzian-Piotrowska M., Gorski J. Metabolic adaptation to daily exercise of moderate intensity to exhaustion in the rat // Eur. J. Appl. physiol. 1993. V. 67. P. 77-82.Zendzian-Piotrowska M., Gorski J. Metabolic adaptation to daily exercise of moderate intensity to exhaustion in the rat // Eur. J. Appl. physiol. 1993. V. 67. P. 77-82.

The authors declare that there are no conflicts of interest present.