scbmtБИОМЕДИЦИНАJournal Biomed2074-59822713-0428Scientific center of biomedical technologies of Federal Medical and Biological Agencyscbmt-713Research ArticleСтатьиПолиморфный маркер Arg16Gly гена ADRB2 не ассоциирован с хронической артериальной гипертонией у русских беременных женщин Polymorphic markers Arg16Gly gene ADRB2 not associated with chronic hypertension in Russian pregnant womenСоковаЕ. А.elmed@yandex.ruЦентр клинической фармакологии ФГБУ НЦ ЭСМП Росздравнадзора РФ, МоскваRussian Federation20111302202014129131Copyright © Сокова Е.А., 20202020Сокова Е.А.Сокова Е.А.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.scbmt.ru/jour/article/view/713

Изучена взаимосвязь полиморфного маркера Arg16Gly гена ADRB2 с хронической артериальной гипертензией у русских беременных женщин. Не обнаружили значимых различий ни по частотам гено- типов, ни по частотам аллелей полиморфного маркера Arg16Gly гена ADRB2, поэтому можно сделать вывод, что полиморфизм Arg16Gly гена ADRB2 не ассоциирован у беременных с хронической артери- альной гипертонией. The relationship of the polymorphic marker gene ADRB2 Arg16Gly with chronic hypertension from Russian pregnant women are studied. Significant differences either in genotype frequencies or allele frequencies of polymorphic marker gene Arg16Gly ADRB2 is not fuond, so it can be concluded that the polymorphism of ADRB2 gene Arg16Gly not associated in women with chronic hypertension.

артериальная гипертония у беременныхгенетический полиморфизмhypertension in pregnancygenetic polymorphismReferencesBrodde O-E. Beta-1 and beta-2 adrenoceptor polymorphisms: functional importance, impact on cardiovascular diseases and drug responses// Pharmacol Ther. 2008. 117. p.1-29.Brodde O-E. Beta-1 and beta-2 adrenoceptor polymorphisms: functional importance, impact on cardiovascular diseases and drug responses// Pharmacol Ther. 2008. 117. p.1-29.Ge D, Huang J, He J, Li B, Duan X, Chen R, Gu D. beta2-Adrenergic receptor gene variations associated with stage-2 hypertension in northern Han Chinese.// Ann Hum Genet. 2005. Jan;69(Pt 1). P. 36-44.Ge D, Huang J, He J, Li B, Duan X, Chen R, Gu D. beta2-Adrenergic receptor gene variations associated with stage-2 hypertension in northern Han Chinese.// Ann Hum Genet. 2005. Jan;69(Pt 1). P. 36-44.Hahntow I.N., Koopmans R.P., Michel M.C. The b2-adrenoceptor gene and hypertension: is it the promoter or the coding region or neither? //J. Hypertens. 2006. 24. р.1003-1007.Hahntow I.N., Koopmans R.P., Michel M.C. The b2-adrenoceptor gene and hypertension: is it the promoter or the coding region or neither? //J. Hypertens. 2006. 24. р.1003-1007.Kirsten Leineweber* and Gerd Heusch. β1- and β2-Adrenoceptor polymorphismsandcardiovascular diseases//Br J Pharmacol. 2009. 158. 1. P. 61-69.Kirsten Leineweber* and Gerd Heusch. β1- and β2-Adrenoceptor polymorphismsandcardiovascular diseases//Br J Pharmacol. 2009. 158. 1. P. 61-69.Pereira AC, Floriano MS, Mota GFA et al. β2 Adrenoceptor functional gene variants, obesity, and blood pressure level interactions in the general population.// Hypertension. 2003. 42. Р. 685-692.Pereira AC, Floriano MS, Mota GFA et al. β2 Adrenoceptor functional gene variants, obesity, and blood pressure level interactions in the general population.// Hypertension. 2003. 42. Р. 685-692.Tomaszewski M, Brain NJ, Charchar FJ. et al. Essential hypertension and beta2-adrenergic receptor gene: linkage and association analysis.//Hypertension. 2002. 40. Р. 286-291.Tomaszewski M, Brain NJ, Charchar FJ. et al. Essential hypertension and beta2-adrenergic receptor gene: linkage and association analysis.//Hypertension. 2002. 40. Р. 286-291.

The authors declare that there are no conflicts of interest present.