<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">scbmt</journal-id><journal-title-group><journal-title xml:lang="ru">БИОМЕДИЦИНА</journal-title><trans-title-group xml:lang="en"><trans-title>Journal Biomed</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2074-5982</issn><issn pub-type="epub">2713-0428</issn><publisher><publisher-name>Scientific center of biomedical technologies of Federal Medical and Biological Agency</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">scbmt-986</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>Состояние клеточной β-адренорецепции при артериальной гипертонии и ее модификация на фоне лечения различными формами 
β-адреноблокатора метопролола</article-title><trans-title-group xml:lang="en"><trans-title></trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Манешина</surname><given-names>О. А.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Леонова</surname><given-names>М. В.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Белоусов</surname><given-names>Ю. Б.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Духанин</surname><given-names>А. С.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>ГОУ ВПО РГМУ, Москва</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2006</year></pub-date><pub-date pub-type="epub"><day>13</day><month>02</month><year>2020</year></pub-date><volume>1</volume><issue>3</issue><fpage>50</fpage><lpage>52</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Манешина О.А., Леонова М.В., Белоусов Ю.Б., Духанин А.С., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Манешина О.А., Леонова М.В., Белоусов Ю.Б., Духанин А.С.</copyright-holder><copyright-holder xml:lang="en">Манешина О.А., Леонова М.В., Белоусов Ю.Б., Духанин А.С.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.scbmt.ru/jour/article/view/986">https://journal.scbmt.ru/jour/article/view/986</self-uri><kwd-group xml:lang="ru"><kwd>Β-адренорецепторы</kwd><kwd>артериальная гипертония</kwd><kwd>β-адреноблокаторы</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Lücker P, Moore G, Wiselgren I, et al. Pharmacokinetic and pharmacodynamic comparison of metoprolol CR/ZOK once daily with conventional tablets once daily and in divided doses. J Clin Pharmacol 1990; 30 (Suppl): S17-27</mixed-citation><mixed-citation xml:lang="en">Lücker P, Moore G, Wiselgren I, et al. Pharmacokinetic and pharmacodynamic comparison of metoprolol CR/ZOK once daily with conventional tablets once daily and in divided doses. J Clin Pharmacol 1990; 30 (Suppl): S17-27</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Plosker GL, Clissold SP. Controlled release metoprolol formulations. A review of their pharmacodynamic and pharmacokinetic properties, and therapeutic use in hypertension and ischaemic heart disease. Drugs 1992; 43 (3): 382-414.</mixed-citation><mixed-citation xml:lang="en">Plosker GL, Clissold SP. Controlled release metoprolol formulations. A review of their pharmacodynamic and pharmacokinetic properties, and therapeutic use in hypertension and ischaemic heart disease. Drugs 1992; 43 (3): 382-414.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Zineh I &lt;http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&amp;cmd=Search&amp;itool=PubMed_Abstract&amp;term=%22Zineh+I%22%5BAuthor%5D&gt;, Beitelshees AL &lt;http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&amp;cmd=Search&amp;itool=PubMed_Abstract&amp;term=%22Beitelshees+AL%22%5BAuthor%5D&gt;, Gaedigk A &lt;http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&amp;cmd=Search&amp;itool=PubMed_Abstract&amp;term=%22Gaedigk+A%22%5BAuthor%5D&gt;, Walker JR &lt;http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&amp;cmd=Search&amp;itool=PubMed_Abstract&amp;term=%22Walker+JR%22%5BAuthor%5D&gt;, Pauly DF &lt;http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&amp;cmd=Search&amp;itool=PubMed_Abstract&amp;term=%22Pauly+DF%22%5BAuthor%5D&gt;, Eberst K &lt;http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&amp;cmd=Search&amp;itool=PubMed_Abstract&amp;term=%22Eberst+K%22%5BAuthor%5D&gt;, Leeder JS &lt;http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&amp;cmd=Search&amp;itool=PubMed_Abstract&amp;term=%22Leeder+JS%22%5BAuthor%5D&gt;, Phillips MS &lt;http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&amp;cmd=Search&amp;itool=PubMed_Abstract&amp;term=%22Phillips+MS%22%5BAuthor%5D&gt;, Gelfand CA &lt;http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&amp;cmd=Search&amp;itool=PubMed_Abstract&amp;term=%22Gelfand+CA%22%5BAuthor%5D&gt;, Johnson JA &lt;http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&amp;cmd=Search&amp;itool=PubMed_Abstract&amp;term=%22Johnson+JA%22%5BAuthor%5D&gt;. Pharmacokinetics and CYP2D6 genotypes do not predict metoprolol adverse events or efficacy in hypertension. Clin Pharmacol Ther. &lt;javascript:AL_get(this,%20'jour',%20'Clin%20Pharmacol%20Ther.');&gt; 2004 Dec;76(6):536-44.</mixed-citation><mixed-citation xml:lang="en">Zineh I &lt;http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&amp;cmd=Search&amp;itool=PubMed_Abstract&amp;term=%22Zineh+I%22%5BAuthor%5D&gt;, Beitelshees AL &lt;http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&amp;cmd=Search&amp;itool=PubMed_Abstract&amp;term=%22Beitelshees+AL%22%5BAuthor%5D&gt;, Gaedigk A &lt;http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&amp;cmd=Search&amp;itool=PubMed_Abstract&amp;term=%22Gaedigk+A%22%5BAuthor%5D&gt;, Walker JR &lt;http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&amp;cmd=Search&amp;itool=PubMed_Abstract&amp;term=%22Walker+JR%22%5BAuthor%5D&gt;, Pauly DF &lt;http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&amp;cmd=Search&amp;itool=PubMed_Abstract&amp;term=%22Pauly+DF%22%5BAuthor%5D&gt;, Eberst K &lt;http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&amp;cmd=Search&amp;itool=PubMed_Abstract&amp;term=%22Eberst+K%22%5BAuthor%5D&gt;, Leeder JS &lt;http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&amp;cmd=Search&amp;itool=PubMed_Abstract&amp;term=%22Leeder+JS%22%5BAuthor%5D&gt;, Phillips MS &lt;http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&amp;cmd=Search&amp;itool=PubMed_Abstract&amp;term=%22Phillips+MS%22%5BAuthor%5D&gt;, Gelfand CA &lt;http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&amp;cmd=Search&amp;itool=PubMed_Abstract&amp;term=%22Gelfand+CA%22%5BAuthor%5D&gt;, Johnson JA &lt;http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&amp;cmd=Search&amp;itool=PubMed_Abstract&amp;term=%22Johnson+JA%22%5BAuthor%5D&gt;. Pharmacokinetics and CYP2D6 genotypes do not predict metoprolol adverse events or efficacy in hypertension. Clin Pharmacol Ther. &lt;javascript:AL_get(this,%20'jour',%20'Clin%20Pharmacol%20Ther.');&gt; 2004 Dec;76(6):536-44.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
