New biomodels of metabolic syndrome
Abstract
The work is devoted to the search and research of new biomodels of metabolic syndrome. Mouse line NZB and CC57Br was investigated like as new biomodel of metabolic syndrome by clinical, biochemical, and morphological methods of analysis, which reproduce the course of the development of the metabolic syndrome and the corresponding pathogenetic, functional and structural changes in the body. It was established that C57Bl/KsLeprdb/+ line of mice can be used as the metabolic syndrome biomodel from the first to the third month of life, NZB and CC57Br mice - starting from the sixth month. Animals of the NZB line have a higher level of glucose and HbA1c, as well as more pronounced obesity, however, aggressiveness was noted in this line compared to animals of the CC57Br.
About the Authors
V. N. Karkischenko
ФГБУН «Научный центр биомедицинских технологий ФМБА России»
Russian Federation
Russian Federation
R. A. Klesov
ФГБУН «Научный центр биомедицинских технологий ФМБА России»
Russian Federation
Russian Federation
O. I. Stepanova
ФГБУН «Научный центр биомедицинских технологий ФМБА России»
Russian Federation
Russian Federation
O. V. Baranova
ФГАУ «Лечебно-реабилитационный центр» Минздрава России
Russian Federation
Russian Federation
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Review
For citations:
Karkischenko V.N., Klesov R.A., Stepanova O.I., Baranova O.V. New biomodels of metabolic syndrome. Journal Biomed. 2018;(4):18-28. (In Russ.)
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