Influence of acute hypobaric hypoxia on reproductive function of laboratory rats and mice Message 1: Research of consequences of influence of acute hypobaric hypoxia at a stage early organogenesis on viability of embryos at females of rats and mice

Abstract

On rats from the strain (HY/Y) low-steady against a hypoxia, deduced and supported in SCBMT of RAMS and on the mice strain C57BL/6Y supported also in collection fund of the Center, investigated consequences of influence of a sharp hypobaric hypoxia on viability of embryos. To acute hypoxia stress of females of both types subjected at the 10th bottom of pregnancy. As a result of the carried-out experiment it is established that the general embryonic mortality was equal in the postimplantation period of development in females of rats of skilled group of 9,5%, at females of mice – 11,2%. Thus the contribution recessive lethal in embryonic mortality at females of rats and at females of mice made 4,36 and 5,1%, respectively. Thus, the share of the lost embryos caused by influence of a hypoxia, equaled at females of rats of 6,0%, at females of mice – 6,1%.