Behavioural Changes in Heterozygous Rats by Gene Knockout of the Dopamine Transporter (DAT)
https://doi.org/10.33647/2074-5982-16-1-82-88
Abstract
This paper presents the results of a comparative analysis of behavioural indicators in rats with modelled genetic dopamine transporter (DAT) deficiency. Two groups of laboratory animals — heterozygous DAT knockout rats (DAT-HET) and Wistar rats — underwent the “Open field”, “Elevated plus maze” and “Extrapolation deliverance” tests. It is established that DAT-HET rats are characterized by an increased locomotor and research activity along with reduced anxiety and cognitive impairment compared to Wistar rats used as control.
About the Authors
A. R. Gainetdinov
Bashkir State University
Russian Federation
Russian Federation
Albert R. Gainetdinov
450076, Republic of Bashkortostan, Ufa, Zaki Validi str., 32
Z. S. Fesenko
Saint Petersburg State University
Russian Federation
Russian Federation
Zoya S. Fesenko
199034, Saint Petersburg, Universitetskaya embankment, 7/9
Z. R. Khismatullina
Bashkir State University
Russian Federation
Russian Federation
Zuhra R. Khismatullina - Dr. Sci. (Biol.), Prof.
450076, Republic of Bashkortostan, Ufa, Zaki Validi str., 32
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Review
For citations:
Gainetdinov A.R., Fesenko Z.S., Khismatullina Z.R. Behavioural Changes in Heterozygous Rats by Gene Knockout of the Dopamine Transporter (DAT). Journal Biomed. 2020;16(1):82-88. (In Russ.) https://doi.org/10.33647/2074-5982-16-1-82-88
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