Information Algorithm for Non-Invasive Evaluation of Osteoresorbable Side Effects of Glucocorticosteroids in Patients with Ulcerative Colitis
https://doi.org/10.33647/2074-5982-16-3-92-96
Abstract
A study involving 45 patients with ulcerative colitis found that the activity of the Cathepsin K bone resorption marker measured by an enzyme-linked immunosorbent assay in gingival fluid could be used as a non-invasive control over the development of steroid osteoporosis caused by systemic use of glucocorticoids. When the concentration of Cathepsin K in the gingival fluid exceeded 3.7 pmol/L, the risk of developing osteoporosis in patients with ulcerative colitis taking glucocorticosteroids on a regular basis increased by 7.9 times with a diagnostic accuracy of 82.6% (p=0.002). As a result of the study, an effective method for non-invasive assessment of osteoresorbable side effects of glucocorticosteroids in autoimmune diseases was proposed.
About the Authors
A. V. Safronenko
Rostov State Medical University of the Ministry of Health Care of Russia
Russian Federation
Russian Federation
Andrey V. Safronenko, Dr. Sci. (Med.), Assoc. Prof.
344022, Rostov-on-Don, Nakhichevansky lane, 29
V. A. Kosenko
Rostov State Medical University of the Ministry of Health Care of Russia
Russian Federation
Russian Federation
Vladislav A. Kosenko
344022, Rostov-on-Don, Nakhichevansky lane, 29
A. A. Demidova
Rostov State Medical University of the Ministry of Health Care of Russia
Russian Federation
Russian Federation
Aleksandra A. Demidova, Cand. Sci. (Med.), Assoc. Prof.
344022, Rostov-on-Don, Nakhichevansky lane, 29
I. A. Demidov
Rostov State Medical University of the Ministry of Health Care of Russia
Russian Federation
Russian Federation
Igor A. Demidov, Cand. Sci. (Med.)
344022, Rostov-on-Don, Nakhichevansky lane, 29
N. V. Sukhorukova
Rostov State Medical University of the Ministry of Health Care of Russia
Russian Federation
Russian Federation
Natalya V. Sukhorukova, Cand. Sci. (Med.)
344022, Rostov-on-Don, Nakhichevansky lane, 29
E. V. Gantsgorn
Rostov State Medical University of the Ministry of Health Care of Russia
Russian Federation
Russian Federation
Elena V. Gantsgorn, Cand. Sci. (Med.)
344022, Rostov-on-Don, Nakhichevansky lane, 29
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Review
For citations:
Safronenko A.V., Kosenko V.A., Demidova A.A., Demidov I.A., Sukhorukova N.V., Gantsgorn E.V. Information Algorithm for Non-Invasive Evaluation of Osteoresorbable Side Effects of Glucocorticosteroids in Patients with Ulcerative Colitis. Journal Biomed. 2020;16(3):92-96. (In Russ.) https://doi.org/10.33647/2074-5982-16-3-92-96
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