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Biomodeling of pulmonary pathologies by means of intratracheal instillation of sensitizing substances in laboratory animals

https://doi.org/10.33647/2713-0428-17-3E-95-98

Abstract

A method for endotracheal administration was studied and optimized for the tasks of the Scientific Centre for Biomedical Technologies (SCBMT), Russia, on small and large laboratory animals. By means of intratracheal instillation of sensitizing substances, a biomodel of coronavirus pneumonia was created and tested in preclinical studies. 

About the Authors

L. A. Taboyakova
Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia
Russian Federation

143442, Moscow Region, Krasnogorsk District, Svetlye Gory Village, 1



O. V. Alimkina
Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia
Russian Federation

143442, Moscow Region, Krasnogorsk District, Svetlye Gory Village, 1



N. S. Ogneva
Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia
Russian Federation

143442, Moscow Region, Krasnogorsk District, Svetlye Gory Village, 1



E. S. Savchenko
Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia
Russian Federation

143442, Moscow Region, Krasnogorsk District, Svetlye Gory Village, 1



References

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2. Makarenko I.E., Avdeeva O.I., Vanatiev G.V., Rybakova A.V., Khodko S.V., Makarova M.N., Makarov V.G. Vozmozhnye puti i ob»emy vvedeniya lekarstvennykh sredstv laboratornym zhivotnym [Possible routes and volumes of drug administration to laboratory animals]. Mezhdunarodnyj vestnik veterinarii [International Veterinary Bulletin]. 2013;3:78–83. (In Russian).

3. Rukovodstvo po laboratornym zhivotnym i al’ternativnym modelyam v biomedicinskih issledovaniyah [Manual on laboratory animals and alternative models in biomedical research]. Ed. by N.N. Karkischenko, et al. Moscow: Profil’-2S Publ., 2010:358. (In Russian).

4. Trofimets E.I., Makarova M.N., Katel`nikova A.E., Kryshen` K.L. Endotraheal’nyj sposob vvedeniya lekarstvennyh sredstv laboratornym zhivotnym [Endotracheal drug administration to laboratory animals]. Laboratornye zhivotnye dlya nauchnyh issledovanij [Laboratory Animals for Science]. 2020;2:65–75. (In Russian). DOI: 10.29296/2618723X-2020-02-08.


Review

For citations:


Taboyakova L.A., Alimkina O.V., Ogneva N.S., Savchenko E.S. Biomodeling of pulmonary pathologies by means of intratracheal instillation of sensitizing substances in laboratory animals. Journal Biomed. 2021;17(3E):95-98. (In Russ.) https://doi.org/10.33647/2713-0428-17-3E-95-98

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ISSN 2074-5982 (Print)
ISSN 2713-0428 (Online)