Investigation of the adjuvant properties of nanoparticles from a birch bark extract used for immunization of mini pigs of the Svetlogorsk population
https://doi.org/10.33647/2713-0428-17-3E-133-138
Abstract
The adjuvant properties of nanoparticles derived from a dry birch bark extract were studied. Immunization experiments were carried out on mini pigs of the Svetlogorsk population, a human biomodel. Animals received two subcutaneous injections of the antigen at a dose of 0.1 mg/kg with an interval of 14 days. The addition of an aqueous suspension of nanoparticles to the immunogen samples up to a final concentration of 0.5 mg/ml led to an increase in the immune response. No side effects were observed. The antibody titers in blood sera on the 60th and 90th days from the start of immunization were comparable to those obtained under similar conditions using Freund’s adjuvant (1:4000).
About the Authors
A. G. Berzina
National Scientific Center of Narcology — Branch of the National Medical Research Center of Psychiatry and Narcology named after V.P. Serbskiy of the Ministry of Health Care of Russia
Russian Federation
Russian Federation
Cand. Sci. (Biol.),
119034, Moscow, Kropotkinskiy lane, 23
N. V. Stankova
Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
143442, Moscow Region, Krasnogorsk District, Svetlye Gory Village, 1
A. P. Kaplun
MIREA — Russian Technological University
Russian Federation
Russian Federation
119454, Moscow, Vernadskogo Avenue, 78
A. A. Burkova
MIREA — Russian Technological University
Russian Federation
Russian Federation
119454, Moscow, Vernadskogo Avenue, 78
N. B. Gamaleya
National Scientific Center of Narcology — Branch of the National Medical Research Center of Psychiatry and Narcology named after V.P. Serbskiy of the Ministry of Health Care of Russia
Russian Federation
Russian Federation
119034, Moscow, Kropotkinskiy lane, 23
References
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Review
For citations:
Berzina A.G., Stankova N.V., Kaplun A.P., Burkova A.A., Gamaleya N.B. Investigation of the adjuvant properties of nanoparticles from a birch bark extract used for immunization of mini pigs of the Svetlogorsk population. Journal Biomed. 2021;17(3E):133-138. (In Russ.) https://doi.org/10.33647/2713-0428-17-3E-133-138
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