The role of cholinergic mechanisms in the effects of GABA on the small bowel electrical activity

Abstract

On a sample of 14 rats, the role of cholinergic mechanisms in the effects of GABA on the small bowel electrical activity under the conditions of 18-hour food deprivation in a chronic experiment was studied. Administration of GABA at a dose of 70 mg/kg resulted in stimulation of phase II (irregular activity) and the disappearance of phases I (rest) and III (regular activity) of the migrating myoelectric complex (MMC). The main effect of the M-cholinoblockator — atropine (1 mg/kg) was manifested in the disappearance of phase III MMC. The administration of GABA after the administration of atropine caused the appearance of extraordinary phase III MMC, thereby exerting a release effect on the regular (propulsive) activity of the small intestine. Therefore, one of the mechanisms of GABA action on the electrical activity of the small intestine is cholinergic pathways.