Experimental pharmacokinetics of the GZK-111 drug preparation exhibiting neuroprotective activity
https://doi.org/10.33647/2713-0428-17-3E-156-160
Abstract
We studied the pharmacokinetics of a drug preparation, ethyl ester of N-phenylacetyl-glycyl-L-proline, exhibiting neuroprotective activity and its metabolite cyclo-L-prolylglycine in rat blood plasma after a single intravenous administration at a dose of 20 mg/kg. The metabolite was found to circulate in the systemic bloodstream of animals twice as long as the ethyl ester of N-phenylacetyl-glycyl-L-proline, with its plasma concentrations being 50–70 times higher than those of the parent compound.
About the Authors
A. L. Podolko
Zakusov Institute of Pharmacology
Russian Federation
Russian Federation
125315, Moscow, Baltiyskaya Str., 8
P. O. Bochkov
Zakusov Institute of Pharmacology
Russian Federation
Russian Federation
Cand. Sci. (Biol.),
125315, Moscow, Baltiyskaya Str., 8
R. V. Shevchenko
Zakusov Institute of Pharmacology
Russian Federation
Russian Federation
Cand. Sci. (Med.),
125315, Moscow, Baltiyskaya Str., 8
A. A. Litvin
Zakusov Institute of Pharmacology
Russian Federation
Russian Federation
Dr. Sci. (Biol.),
125315, Moscow, Baltiyskaya Str., 8
G. B. Kolyvanov
Zakusov Institute of Pharmacology
Russian Federation
Russian Federation
Dr. Sci. (Biol.),
125315, Moscow, Baltiyskaya Str., 8
V. P. Zherdev
Zakusov Institute of Pharmacology
Russian Federation
Russian Federation
Dr. Sci. (Med.), Prof.,
125315, Moscow, Baltiyskaya Str., 8
References
1. Antipova T.A., Kolyasnikova K.N., Volkova Yu.S., Antipov P.I., Kuznetsova E.A., Nikolaev S.V. Neyroprotektornye svoystva in vitro novykh zameshchennykh gliprolinov [Neuroprotective properties of novel substituted glyprolines in vitro]. Pharmacokinetics and Pharmacodynamics. 2018;3:31–36. (In Russian). DOI: 10.24411/2587-7836-2018-10021.
2. Gudasheva T.A., Kolyasnikova K.N., Kuznetsova E.A., et al. Etilovyy efir N-fenilatsetil-glitsil-L-prolina metaboliziruetsya do tsiklo-L-prolilglitsina, proyavlyaya skhodnyy spektr neyropsikhotropnoy aktivnosti [N-phenylacetylglycylL-proline ethyl ester converts into cyclo-L-prolylglycine showing a similar spectrum of neuropsychotropic activity]. Chemistry and Pharmaceutical Journal. 2017;50(11):705–710. (In Russian). DOI: 10.1007/ s11094-017-1516-4
3. Zhuikova S.E. Gliproliny — regulyatornye peptidy s integrativnym deystviem [Glyprolines: Regulatory peptides with an integrative action]. Integrative Physiology. 2020;1(4):303–316. (In Russian). DOI: 10.33910/2687-1270-2020-1-4-303-316.
4. Nikolaev S.V., Logvinov I.O., Koliasnikova K.N., Kuznetsova E.A., Antipov P.I., Antipova T.A. Neyroprotektornye svoystva in vitro novykh gliprolinov, zameshchennykh po N-kontsu [In vitro neuroprotective activity of analogues of N-terminus substituted glyprolines]. Pharmacokinetics and Pharmacodynamics. 2020;2:4– 10. (In Russian). DOI: 10.37489/2587-7836-2020-2-4-10.
5. Khavinson V.Kh. Lekarstvennye peptidnye preparaty: proshloe, nastoyashchee, budushchee [Peptide medicines: Past, present, future]. Clinical Medicine. 2020;98(3):165–177. (In Russian). DOI: 10.30629/0023-2149-2020-98-3-165-177.
6. Apostolopoulos V., Bojarska J., Chai T.-T. A global review on short peptides. Frontiers and Perspectives Molecules. 2021;26:430. DOI: 10.3390/molecules26020430.
Review
For citations:
Podolko A.L., Bochkov P.O., Shevchenko R.V., Litvin A.A., Kolyvanov G.B., Zherdev V.P. Experimental pharmacokinetics of the GZK-111 drug preparation exhibiting neuroprotective activity. Journal Biomed. 2021;17(3E):156-160. (In Russ.) https://doi.org/10.33647/2713-0428-17-3E-156-160
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