Edative activity of a new allylmorpholine derivative in the novel tank diving test in zebrafish Danio rerio
https://doi.org/10.33647/2713-0428-17-3E-161-164
Abstract
A new chromone-containing allylmorpholine derivative, (E)-4-[1-(8-bromo-6-methyl-4-oxo-4H-chromen3-yl)-4-methylpent-1-en-3-yl]morpholin-4-ium chloride, was screened for behavioral effects in zebrafish Danio rerio using the novel tank diving test. Based on the observed alterations in behavior, the compound was confirmed to exert a sedative effect in zebrafish.
About the Authors
V. A. Prikhodko
St. Petersburg State Chemical and Pharmaceutical University of the Ministry of Health Сare of Russia
Russian Federation
Russian Federation
197376, St. Petersburg, Professora Popova Str., 14, let. A
Yu. I. Sysoev
St. Petersburg State Chemical and Pharmaceutical University of the Ministry of Health Сare of Russia;
St. Petersburg State University
Russian Federation
Russian Federation
Cand. Sci. (Biol.), 197376, St. Petersburg, Professora Popova Str., 14, let. A;
199034, St. Petersburg, Universitetskaya Embankment, 7–9
References
1. Chernov N.M., Shutov R.V., Barygin O.I., et al. Synthesis of chromone-containing allylmorpholines through a Morita-Baylis-Hillman-type reaction. Eur. J. Org. Chem. 2018;2018(45):6304–6313. DOI: 10.1002/ejoc.201801159.
2. Demin K.A., Kolesnikova T.O., Khatsko S.L., et al. Acute effects of amitriptyline on adult zebrafish: Potential relevance to antidepressant drug screening and modeling human toxidromes. Neurotoxicol. Teratol. 2017;62:27–33. DOI: 10.1016/j.ntt.2017.04.002.
3. Egan R.J., Bergner C.L., Hart P.C., et al. Understanding behavioral and physiological phenotypes of stress and anxiety in zebrafish. Behav. Brain Res. 2009;205(1):38–44. DOI: 10.1016/j.bbr.2009.06.022.
Review
For citations:
Prikhodko V.A., Sysoev Yu.I. Edative activity of a new allylmorpholine derivative in the novel tank diving test in zebrafish Danio rerio. Journal Biomed. 2021;17(3E):161-164. (In Russ.) https://doi.org/10.33647/2713-0428-17-3E-161-164
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