Edative activity of a new allylmorpholine derivative in the novel tank diving test in zebrafish Danio rerio
https://doi.org/10.33647/2713-0428-17-3E-161-164
Abstract
A new chromone-containing allylmorpholine derivative, (E)-4-[1-(8-bromo-6-methyl-4-oxo-4H-chromen3-yl)-4-methylpent-1-en-3-yl]morpholin-4-ium chloride, was screened for behavioral effects in zebrafish Danio rerio using the novel tank diving test. Based on the observed alterations in behavior, the compound was confirmed to exert a sedative effect in zebrafish.
About the Authors
V. A. PrikhodkoRussian Federation
197376, St. Petersburg, Professora Popova Str., 14, let. A
Yu. I. Sysoev
Russian Federation
Cand. Sci. (Biol.), 197376, St. Petersburg, Professora Popova Str., 14, let. A;
199034, St. Petersburg, Universitetskaya Embankment, 7–9
References
1. Chernov N.M., Shutov R.V., Barygin O.I., et al. Synthesis of chromone-containing allylmorpholines through a Morita-Baylis-Hillman-type reaction. Eur. J. Org. Chem. 2018;2018(45):6304–6313. DOI: 10.1002/ejoc.201801159.
2. Demin K.A., Kolesnikova T.O., Khatsko S.L., et al. Acute effects of amitriptyline on adult zebrafish: Potential relevance to antidepressant drug screening and modeling human toxidromes. Neurotoxicol. Teratol. 2017;62:27–33. DOI: 10.1016/j.ntt.2017.04.002.
3. Egan R.J., Bergner C.L., Hart P.C., et al. Understanding behavioral and physiological phenotypes of stress and anxiety in zebrafish. Behav. Brain Res. 2009;205(1):38–44. DOI: 10.1016/j.bbr.2009.06.022.
Review
For citations:
Prikhodko V.A., Sysoev Yu.I. Edative activity of a new allylmorpholine derivative in the novel tank diving test in zebrafish Danio rerio. Journal Biomed. 2021;17(3E):161-164. (In Russ.) https://doi.org/10.33647/2713-0428-17-3E-161-164