Small Bowel Electrical Activity in an Experimental Model of Hypochlorhydria
https://doi.org/10.33647/2074-5982-18-3-58-61
Abstract
Variations in the basic parameters of the electrical activity of the small intestine in rats were studied using an experimental model of hypochlorhydria caused by an intragastric administration of rabeprazole for 16 days. Hypochlorhydria was found to lead to an increased duration of irregular electric activity and a reduction in the period of quiescence, which indicates an increase in uncoordinated contractions of the small intestine. A decrease in the number of migrating myoelectric complexes and, consequently, a partial suppression of propulsive peristalsis contributes to an excessive bacterial overgrowth in the proximal small intestine.
About the Authors
I. G. Vilkova
N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health Care Department
Russian Federation
Russian Federation
Irina G. Vilkova.
129090, Moscow, Bolshaya Sukharevskaya Square, 3.
N. S. Tropskaya
N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health Care Department; Moscow Aviation Institute (National Research University)
Russian Federation
Russian Federation
Nataliva S. Tropskava - Dr. Sci. (Biol.), N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health Care Department; Moscow Aviation Institute (National Research University).
129090, Moscow, Bolshaya Sukharevskaya Square, 3; 125993, Moscow, Volokolamskoe Highway, 4.
T. V. Chernen'kaya
N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health Care Department
Russian Federation
Russian Federation
Tatvana V. Chernen'kava - Cand. Sci. (Med.), N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health Care Department.
129090, Moscow, Bolshaya Sukharevskaya Square, 3.
T. S. Popova
N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health Care Department
Russian Federation
Russian Federation
Tamara S. Popova - Dr. Sci. (Biol.), Prof., N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health Care Department.
129090, Moscow, Bolshaya Sukharevskaya Square, 3.
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Review
For citations:
Vilkova I.G., Tropskaya N.S., Chernen'kaya T.V., Popova T.S. Small Bowel Electrical Activity in an Experimental Model of Hypochlorhydria. Journal Biomed. 2022;18(3):58-61. (In Russ.) https://doi.org/10.33647/2074-5982-18-3-58-61
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