Effect of the Succinic Salt of Diethylethanolamine Fumar Ester on Cognitive Functions of Laboratory Animals
https://doi.org/10.33647/2074-5982-18-3-104-108
Abstract
The effect of succinic salt of diethylethanolamine fumaric ester on the cognitive abilities of male CBA mice and outbred male rats was studied. It was found that the test substance at doses of 10 and 75 mg/kg in the “Extrapolation escape task” test has a positive effect on the short-term and long-term memory of animals, contributing to the preservation and reproduction of the information received. In the “T-maze” test, the succinic salt of diethylethanolamine fumaric ester in both doses was superior, and in the “Extrapolation escape task” test, it had a comparable effect with the reference drug piracetam (dose 900 mg/kg).
About the Authors
V. Ts. Bolotova
Saint-Petersburg State Chemical and Pharmaceutical University
Russian Federation
Russian Federation
Vera Ts. Bolotova - Cand. Sci. (Pharm.), Assoc. Prof., St. Petersburg State Chemical and Pharmaceutical University of the Ministry of Health Care of Russia.
197376, St. Petersburg, Professora Popova Str., 14, lit. A.
I. A. Titovich
Saint-Petersburg State Chemical and Pharmaceutical University
Russian Federation
Russian Federation
Irina A. Titovich - Cand. Sci. (Biol.), Assoc. Prof., St. Petersburg State Chemical and Pharmaceutical University of the Ministry of Health Care of Russia.
197376, St. Petersburg, Professora Popova Str., 14, lit. A.
E. B. Shustov
Saint-Petersburg State Chemical and Pharmaceutical University
Russian Federation
Russian Federation
Evgeniy B. Shustov - Dr. Sci. (Med.), Prof., St. Petersburg State Chemical and Pharmaceutical University of the Ministry of Health Care of Russia.
197376, St. Petersburg, Professora Popova Str., 14, lit. A.
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Review
For citations:
Bolotova V.Ts., Titovich I.A., Shustov E.B. Effect of the Succinic Salt of Diethylethanolamine Fumar Ester on Cognitive Functions of Laboratory Animals. Journal Biomed. 2022;18(3):104-108. (In Russ.) https://doi.org/10.33647/2074-5982-18-3-104-108
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