Experimental Evaluation of the Effectiveness and Safety of a New Propandic Acid Derivative Exhibiting Cardiotropic Action
https://doi.org/10.33647/2074-5982-18-3-109-112
Abstract
An entire cycle of preclinical studies of 4-[(3-ethoxy-3-oxopropanoyl)amino]benzoic acid (etmaben) exhibiting cardiotropic action was carried out. Its potential action mechanism and pharmacological effects, general toxic effects in acute and chronic experiments, specific types of toxicity (allergenicity, immunotoxicity, reproductive toxicity, mutagenicity), and pharmacokinetics were studied. The drug was found to have a pronounced cardiotropic effect and a positive safety profile, which justifies the launch of phase I clinical trials.
About the Authors
D. Yu. Ivkin
Saint-Petersburg State Chemical and Pharmaceutical University; The Herzen State Pedagogical University of Russia
Russian Federation
Russian Federation
Dmitry Yu. Ivkin - Cand. Sci. (Biol.), Assoc. Prof., St. Petersburg State Chemical and Pharmaceutical University of the Ministry of Health Care of Russia, The Herzen State Pedagogical University of Russia.
197376, St. Petersburg, Professora Popova Str., 14, lit. A; 191186, Saint Petersburg, Embankment of the Moika River, 48.
A. A. Karpov
Saint-Petersburg State Chemical and Pharmaceutical University
Russian Federation
Russian Federation
Andrey A. Karpov - Cand. Sci. (Med.), St. Petersburg State Chemical and Pharmaceutical University of the Ministry of Health Care of Russia.
197376, St. Petersburg, Professora Popova Str., 14, lit. A.
References
1. Ivkin D.Yu., Karpov A.A., Dracheva A.V., et al. Vliyanie proizvodnogo benzoynoy kisloty na formirovanie eksperimental'noy khronicheskoy serdechnoy nedostatochnosti [Effect of a benzoic acid derivative on the development of experimental chronic heart failure]. Pharmacy. 2016;63(4):49-52. (In Russian).
2. Kazachenko A.A., Okovityj S.V., Kulikov A.N., et al. Eksperimental'noe modelirovanie khronicheskoy serdechnoy nedostatochnosti [Experimental modeling of chronic warm insufficiency]. Biomeditsina [Journal Biomed]. 2013;3:41-48. (In Russian).
3. Karpov A.A., Ivkin D.Yu., Dracheva A.V., et al. Modelirovanie postinfarktnoy serdechnoy nedostatochnosti putem okklyuzii levoy koronarnoy arterii u krys: tekhnika i metody morfofunktsional'noy otsenki [Rat model of post-infarct heart failure by left coronary artery occlusion: Technical aspects, functional and morphological assessment]. Biomeditsina [Journal Biomed]. 2014;3:32-48. (In Russian).
Review
For citations:
Ivkin D.Yu., Karpov A.A. Experimental Evaluation of the Effectiveness and Safety of a New Propandic Acid Derivative Exhibiting Cardiotropic Action. Journal Biomed. 2022;18(3):109-112. (In Russ.) https://doi.org/10.33647/2074-5982-18-3-109-112
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