Effect of Saccharina latissima Extract on the Antioxidant System Parameters of Rat Blood After Exposure to Carbendazim
https://doi.org/10.33647/2074-5982-18-3-113-117
Abstract
An experimental study of antioxidant parameters in rats after exposure to carbendazim was carried out to study the effect of their pharmacological correction by an intragastric administration of Saccharina latissima extract at a dose of 250 mg/kg for 14 days. The extract under study was found to reduce the activity of lipid peroxidation and promote the neutralization of hydrogen peroxide.
About the Authors
M. V. Melnikova
Golikov Research Clinical Center of Toxicology of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Margarita V. Melnikova.
192019, Saint Petersburg, Bekhtereva Str., 1.
V. A. Kashuro
St. Petersburg State Pediatric Medical University of the Ministry of Health Care of Russia; Herzen State Pedagogical University of Russia
Russian Federation
Russian Federation
Vadim A. Kashuro - Dr. Sci. (Med.), Assoc. Prof., St. Petersburg State Pediatric Medical University of the Ministry of Health Care of Russia; Herzen State Pedagogical University of Russia.
194100, Saint-Petersburg, Litovskaya Str., 2; 191186, Saint Petersburg, Embankment of the Moika River, 48.
E. G. Batotsyrenova
Golikov Research Clinical Center of Toxicology of the Federal Medical and Biological Agency of Russia; St. Petersburg State Pediatric Medical University of the Ministry of Health Care of Russia
Russian Federation
Russian Federation
Ekaterina G. Batotsyrenova - Cand. Sci. (Biol.), Assoc. Prof., Golikov Research Clinical Center of Toxicology of the Federal Medical and Biological Agency of Russia; St. Petersburg State Pediatric Medical University of the Ministry of Health Care of Russia.
192019, Saint Petersburg, Bekhtereva Str., 1; 194100, Saint-Petersburg, Litovskaya Str., 2.
L. G. Kubarskaya
Golikov Research Clinical Center of Toxicology of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Larisa G. Kubarskaya - Cand. Sci. (Biol.), Golikov Research Clinical Center of Toxicology of the Federal Medical and Biological Agency of Russia.
192019, Saint Petersburg, Bekhtereva Str., 1.
E. A. Zolotoverkhaia
Golikov Research Clinical Center of Toxicology of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Ekaterina A. Zolotoverkhaia - Cand. Sci. (Biol.), Golikov Research Clinical Center of Toxicology of the Federal Medical and Biological Agency of Russia.
192019, Saint Petersburg, Bekhtereva Str., 1.
T. A. Kolbasova
Golikov Research Clinical Center of Toxicology of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Taisiia A. Kolbasova - Cand. Sci. (Med.), Golikov Research Clinical Center of Toxicology of the Federal Medical and Biological Agency of Russia.
192019, Saint Petersburg, Bekhtereva Str., 1.
O. A. Vakunenkova
Golikov Research Clinical Center of Toxicology of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Olga A. Vakunenkova.
192019, Saint Petersburg, Bekhtereva Str., 1.
A. S. Gladchuk
Golikov Research Clinical Center of Toxicology of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Aleksey S. Gladchuk.
192019, Saint Petersburg, Bekhtereva Str., 1.
References
1. Batotsyrenova E.G., Kashuro V.A., Sharabanov A.V. Farmakologicheskaya korrektsiya otdalennykh posledstviy ostrogo tyazhelogo otravleniya tiopentalom natriya v usloviyakh khronicheskogo svetovogo desinkhronoza [Pharmacological correction of longterm effects of acute severe poisoning with sodium thiopental under chronic light desynchronosis]. Biomedicina [Journal Biomed]. 2021;17(3):23-28. (In Russian). DOI: 10.33647/2074-5982-17-3-23-28.
2. Krasnov К.А., Gladchuk A.S., Alexandrova M.L., Keltsieva O.A., Zaytseva M.A., Melnikova M.V., Reinyuk V.L., Podolskaya E.P. Izuchenie sostava lipidnykh pigmentov belomorskoy vodorosli Saccharina latissima metodami TSKh i MALDI-MS [Study of the lipid pigment composition in the white sea algae Saccharina latissima using TLC and MALDI-MS]. Toksikologicheskij vestnik [Toxicological Review]. 2020;(5):50-56. (In Russian). DOI: 10.36946/08697922-2020-5-50-56.
3. Podosinovikova N.P., Krasnov К.А., Bondarenko A.A., Alexandrova M.L., Zaytseva M.A., Khalaman V.V. Izuchenie toksichnosti i bezopasnosti lipofil'nykh ekstraktov belomorskikh burykh vodorosley — fukusa puzyrchatogo i laminarii sakharistoy na modeli Daphnia magna Straus [Studying the toxicity and safety of the lipophilic extracts of belomorian brown algae — fucus vesiculosus and saccharina latissima on the Daphnia magna Straus model]. Toksikologicheskiy vestnik [Toxicological Review]. 2020;4:49-55. (In Russian). DOI: 10.36946/0869-7922-2020-4-49-55.
4. Muthuviveganandavel V., Muthuraman P., Muthu S., Srikumar K. Toxic effects of carbendazim at low dose levels in male rats. J. Toxicol. Sci. 2008;33(1):25-30. DOI: 10.2131/jts.33.25.
5. Selmanoglu G., Barlas N., Songur S., Ko^kaya E.A. Carbendazim-induced haematological, biochemical and histopathological changes to the liver and kidney of male rats. Hum. Exp. Toxicol. 2001;20(12):625-630. DOI: 10.1191/096032701718890603.
Review
For citations:
Melnikova M.V., Kashuro V.A., Batotsyrenova E.G., Kubarskaya L.G., Zolotoverkhaia E.A., Kolbasova T.A., Vakunenkova O.A., Gladchuk A.S. Effect of Saccharina latissima Extract on the Antioxidant System Parameters of Rat Blood After Exposure to Carbendazim. Journal Biomed. 2022;18(3):113-117. (In Russ.) https://doi.org/10.33647/2074-5982-18-3-113-117
Views:
285
Email this article 
