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Effect of Infrared Radiation on the Regulation of Oxidative Netabolism in C57BL/KsJYLeprdb/+ Mice

https://doi.org/10.33647/2713-0428-19-3E-59-65

Abstract

We studied the effect of infrared radiation (IR) course exposure on pathological changes in the tissues of C57BL/KsJYLeprdb/+ (db/db) mutant mice with type 2 diabetes mellitus using a LASMA ST device. This apparatus allows simultaneous non-invasive monitoring of blood and lymph microcirculation, as well as determining the activity of mitochondrial oxidative coenzymes in tissues before and after IR therapy. IR waves (690 nm) were found to have a positive therapeutic effect on the functional state of db/db mice. This included a rapid healing of skin wounds caused by maceration and prolonged normalization of oxidative metabolism parameters (NADH, FAD, POM) in body tissues. IR therapy has a cumulative effect, leading to a 2.3–2.5-fold increase in life expectancy and life quality, compared to the control group.

About the Authors

O. I. Stepanova
Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia
Russian Federation

Olga I. Stepanova - Cand. Sci. (Biol.).

143442, Moscow Region, Krasnogorsk District, Svetlye Gory Village, 1



R. A. Klesov
Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia
Russian Federation

Roman A. Klesov

143442, Moscow Region, Krasnogorsk District, Svetlye Gory Village, 1



Kh. Kh. Semenov
Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia
Russian Federation

Khyzyr Kh. Semenov - Cand. Sci. (Biol.).

143442, Moscow Region, Krasnogorsk District, Svetlye Gory Village, 1



I. A. Pomytkin
Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia
Russian Federation

Igor A. Pomytkin - Cand. Sci. (Chem.)

143442, Moscow Region, Krasnogorsk District, Svetlye Gory Village, 1



V. N. Karkischenko
Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia
Russian Federation

Vladislav N. Karkischenko - Dr. Sci. (Med.), Prof.

143442, Moscow Region, Krasnogorsk District, Svetlye Gory Village, 1



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For citations:


Stepanova O.I., Klesov R.A., Semenov Kh.Kh., Pomytkin I.A., Karkischenko V.N. Effect of Infrared Radiation on the Regulation of Oxidative Netabolism in C57BL/KsJYLeprdb/+ Mice. Journal Biomed. 2023;19(3E):59-65. (In Russ.) https://doi.org/10.33647/2713-0428-19-3E-59-65

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ISSN 2074-5982 (Print)
ISSN 2713-0428 (Online)