Efficacy of High Doses of Protons on the Induction of Solid Tumors in Mice by Ex vivo Irradiation of Ehrlich Ascitic Carcinoma Cells
https://doi.org/10.33647/2713-0428-19-3E-66-70
Abstract
We study the induction patterns of the solid form of Ehrlich ascitic carcinoma (EAC) in mice in the short(1 month) and long-term (18 months) periods after inoculation of ascitic cells irradiated ex vivo with a proton beam at doses of 30, 60, 90, 120, and 150 Gr. The growth rate of solid tumors after inoculation of irradiated cells ex vivo coincided with the growth of tumors in the control group. The frequency of tumor induction in mice transplanted with EAC cells was dose-dependent and decreased from 80% to 0% along with an increase in radiation dose. Thus, using the ex vivo model of tumor cell irradiation followed by in vivo grafting allowed us to determine the parameters of the antitumor effect of new proton therapy regimens.
Supporting agencies: the work was carried out within fundamental scientific research on the topic of GZ No. 075-013027-22-00 and at the expense of partial financial support from the funds of the agreement between the
About the Authors
N. S. Strelnikova
Branch “Physical Technical Center”, P.N. Lebedev Physical Institute of the Russian Academy of Sciences
Russian Federation
Russian Federation
Nataliia S. Strelnikova
142281, Moscow Region, Protvino, Akademicheskiy Passage, 2
O. M. Rozanova
Institute of Theoretical and Experimental Biophysics of the Russian Academy of Sciences
Russian Federation
Russian Federation
Olga M. Rozanova
142290, Moscow Region, Pushchino, Institutskaya Str., 3
H. N. Smirnova
Institute of Theoretical and Experimental Biophysics of the Russian Academy of Sciences
Russian Federation
Russian Federation
Helena N. Smirnova
142290, Moscow Region, Pushchino, Institutskaya Str., 3
T. A. Belyakova
Branch “Physical Technical Center”, P.N. Lebedev Physical Institute of the Russian Academy of Sciences
Russian Federation
Russian Federation
Tatiana A. Belyakova
142281, Moscow Region, Protvino, Akademicheskiy Passage, 2
A. V. Smirnov
Branch “Physical Technical Center”, P.N. Lebedev Physical Institute of the Russian Academy of Sciences
Russian Federation
Russian Federation
Aleksandr V. Smirnov
142281, Moscow Region, Protvino, Akademicheskiy Passage, 2
References
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Review
For citations:
Strelnikova N.S., Rozanova O.M., Smirnova H.N., Belyakova T.A., Smirnov A.V. Efficacy of High Doses of Protons on the Induction of Solid Tumors in Mice by Ex vivo Irradiation of Ehrlich Ascitic Carcinoma Cells. Journal Biomed. 2023;19(3E):66-70. (In Russ.) https://doi.org/10.33647/2713-0428-19-3E-66-70
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