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Experimental Study of the Efficacy of Pharmaconutrient Enteral Nutrition and Inulin in the Correction of Intestinal Motor Disorders and Microbiocenosis in the Postoperative Period Under Endotoxemia Conditions

https://doi.org/10.33647/2713-0428-19-3E-71-76

Abstract

A scheme for correcting intestinal motor disorders and microbiocenosis is proposed. Experiments on rats included a sequential jejunum administration of pharmaconutrient enteral nutrition (Intestamine, containing glutamine and tributyrin) and inulin, a prebiotic preparation. The application of this scheme in the postoperative period in the setting of endotoxemia prevents excessive bacterial growth in the jejunum, stimulates the appearance of propulsive peristalsis, eliminates pathological motility patterns and promotes early recovery of coordinated peristalsis of the small intestine.

About the Authors

N. S. Tropskaya
N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health Department; Moscow Aviation Institute (National Research University)
Russian Federation

Nataliya S. Tropskaya - Dr. Sci. (Biol.).

129090, Moscow, B. Sukharevskaya Sq., 3; 125993, Moscow, Volokolamskoe Highway, 4



E. A. Kislyаkova
N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health Department
Russian Federation

Ekaterina A. Kislyakova - Cand. Sci. (Biol.).

129090, Moscow, B. Sukharevskaya Sq., 3



I. G. Vilkova
N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health Department
Russian Federation

Irina G. Vilkova

129090, Moscow, B. Sukharevskaya Sq., 3



Yu. V. Gurman
N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health Department
Russian Federation

Yulia V. Gurman

129090, Moscow, B. Sukharevskaya Sq., 3



O. S. Kislitsyna
N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health Department
Russian Federation

Oksana S. Kislitsyna

129090, Moscow, B. Sukharevskaya Sq., 3



Ye. N. Borodina
N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health Department
Russian Federation

Yevgeniya N. Borodina

129090, Moscow, B. Sukharevskaya Sq., 3



T. V. Chernen’kaya
N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health Department
Russian Federation

Tatyana V. Chernen’kaya - Cand. Sci. (Med.).

129090, Moscow, B. Sukharevskaya Sq., 3



T. S. Popova
N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health Department
Russian Federation

Tamara S. Popova - Dr. Sci. (Biol.), Prof.

129090, Moscow, B. Sukharevskaya Sq., 3



References

1. Kislyakova E.A., Tropskaya N.S., Popova T.S. Enteral'noe vvedenie tributirina kak komponenta nutritivnoj podderzhki v korrekcii narushenij elektricheskoj aktivnosti tonkoj kishki pri eksperimental'noj endotoksemii [Enteral administration of tributyrin as an element of nutritional support in the treatment of disruption of the intestinal electrical activity during experimental endotoxemia]. Biomedicina [Journal Biomed]. 2015;4:77–83. (In Russian).

2. Popova T.S., Tropskaya N.S. Farmakonutrienty. Parenteral'noe i enteral'noe pitanie: nats. ruk-vo. [Pharmaconutrients. Parenteral and enteral nutrition: Nat. Guideline] / Ed. by Petrikov S.S., Hubutiya M.Sh., Popova T.S., 2023, 2nd ed. Moscow: GEOTAR-Media Publ., 2023:259–296. (In Russian).

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5. Hou Y., Wang L., Yi D., Ding B., Chen X., Wang Q., Zhu H., Liu Y., Yin Y., Gong J., Wu G. Dietary supplementation with tributyrin alleviates intestinal injury in piglets challenged with intrarectal administration of acetic acid. Br. J. Nutr. 2014;111(10):1748–1758. DOI: 10.1017/S0007114514000038.

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For citations:


Tropskaya N.S., Kislyаkova E.A., Vilkova I.G., Gurman Yu.V., Kislitsyna O.S., Borodina Ye.N., Chernen’kaya T.V., Popova T.S. Experimental Study of the Efficacy of Pharmaconutrient Enteral Nutrition and Inulin in the Correction of Intestinal Motor Disorders and Microbiocenosis in the Postoperative Period Under Endotoxemia Conditions. Journal Biomed. 2023;19(3E):71-76. (In Russ.) https://doi.org/10.33647/2713-0428-19-3E-71-76

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ISSN 2074-5982 (Print)
ISSN 2713-0428 (Online)