Efficacy Assessment of Dual Combined Therapy in Experimental Chronic Heart Failure
https://doi.org/10.33647/2074-5982-20-3-75-79
Abstract
The article presents the results of experimental studies into the efficacy of dual combinations of conventional drugs for the basic treatment of chronic heart failure with empagliflozin when modeling the pathology in laboratory outbred rats. As part of the study, survival, physical tolerance, and echocardiographic parameters were assessed. The most effective combination was found to be the therapy by empagliflozin with fosinopril. In this case, the six-month survival rate achieved 90%; a greater tolerance to physical activity was observed (50% increase in relation to animals in the pathology group without treatment); shortening and ejection fractions increased by 25%.
About the Authors
D. Yu. Ivkin
Saint Petersburg State Chemical and Pharmaceutical University of the Ministry of Health Care of Russia
Russian Federation
Russian Federation
Dmitry Yu. Ivkin, Cand. Sci. (Biol.), Assoc. Prof.
197376, Saint Petersburg, Professora Popova Str., 14, lit. A
M. V. Krasnova
Saint Petersburg State Chemical and Pharmaceutical University of the Ministry of Health Care of Russia
Russian Federation
Russian Federation
Marina V. Krasnova
197376, Saint Petersburg, Professora Popova Str., 14, lit. A
A. A. Karpov
Saint Petersburg State Chemical and Pharmaceutical University of the Ministry of Health Care of Russia
Russian Federation
Russian Federation
Andrew A. Karpov, Cand. Sci. (Med.)
197376, Saint Petersburg, Professora Popova Str., 14, lit. A
S. V. Okovitiy
Saint Petersburg State Chemical and Pharmaceutical University of the Ministry of Health Care of Russia
Russian Federation
Russian Federation
Sergey V. Okovitiy, Dr. Sci. (Med.), Prof.
197376, Saint Petersburg, Professora Popova Str., 14, lit. A
A. N. Kulikov
First Saint Petersburg State Medical University named after Academician I.P. Pavlov of the Ministry of Health Care of Russia
Russian Federation
Russian Federation
Alexander N. Kulikov, Dr. Sci. (Med.), Prof.
197022, Saint Petersburg, L’va Tolstogo Str., 6–8
References
1. [Karpov A.A., Ivkin D.Yu., Dracheva A.V., Pitukhina N.N., Uspenskaya Yu.K., Vaulina D.D., Uskov I.S., Eyvazova Sh.D., Minasyan S.M., Vlasov T.D., Buryakina A.V., Galagudza M.M. Modelirovanie postinfarktnoy serdechnoy nedostatochnosti putem okklyuzii levoy koronarnoy arterii u krys: tekhnika i metody morfofunktsional'noy otsenki [Rat model of post-infarct heart failure by left coronary artery occlusion: Technical aspects, functional and morphological assessment]. Biomeditsina [Journal Biomed]. 2014;3:32–48. (In Russian)].
2. Krasnova M., Kulikov A., Okovityi S., Ivkin D., Karpov A., Kaschina E., Smirnov A. Comparative efficacy of empagliflozin and drugs of baseline therapy in post-infarct heart failure in normoglycemic rats. Naunyn Schmiedebergs Arch. Pharmacol. 2020;393(9):1649–1658. DOI: 10.1007/s00210-020-01873-7
Review
For citations:
Ivkin D.Yu., Krasnova M.V., Karpov A.A., Okovitiy S.V., Kulikov A.N. Efficacy Assessment of Dual Combined Therapy in Experimental Chronic Heart Failure. Journal Biomed. 2024;20(3):75-79. (In Russ.) https://doi.org/10.33647/2074-5982-20-3-75-79
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