Metabolic Response of Laboratory Rats to Extreme Hyperthermia
https://doi.org/10.33647/2074-5982-20-3-80-83
Abstract
The dynamics of basic parameters of metabolism and lipid peroxidation in the blood serum of rats was studied during the formation of a state of hyperthermia (exposure to air at a temperature of +40 °C for 60 min). It was found that the albumin/globulin ratio, uric acid, cholesterol, triglycerides, blood electrolytes, as well as the activity of the enzymes alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, superoxide dismutase, glutathione peroxidase under short-term heat exposure did not have statistically significant differences from the values in the state of normothermia. The level of lipid hydroperoxides and reduced glutathione changes significantly already during the mobilization phase of thermoregulatory mechanisms. The dynamics of these indicators are stable, which allows these indicators to be correlated with hyperthermia itself.
About the Authors
A. E. Kim
Military Medical Academy named after S.M. Kirov of the Ministry of Defense of Russia
Russian Federation
Russian Federation
Aleksey E. Kim, Cand. Sci. (Med.), Assoc. Prof.
194044, Saint Petersburg, Lebedeva Str., 6
E. B. Shustov
Golikov Research Clinical Center of Toxicology of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Evgeniy B. Shustov, Dr. Sci. (Med.), Prof.
192019, Saint Petersburg, Bekhtereva Str., 1
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Review
For citations:
Kim A.E., Shustov E.B. Metabolic Response of Laboratory Rats to Extreme Hyperthermia. Journal Biomed. 2024;20(3):80-83. (In Russ.) https://doi.org/10.33647/2074-5982-20-3-80-83
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