Experimental Modeling of Heart Failure in Mice
https://doi.org/10.33647/2074-5982-20-3-84-88
Abstract
The article presents the results of testing a heart failure model in laboratory animals by single administration of amyloidogen. White outbred mice were used as biomodels, which were divided into intact and experimental groups. Animals from the experimental group were once injected with amyloidogen containing mouse myocardial homogenate to reproduce a pronounced cardiopathic effect. Structural and functional changes of the myocardium were monitored using echocardiography. According to the results obtained, animals in the experimental group demonstrated a remodeling of the heart similar to restrictive cardiomyopathy and a myocardial disfunction of both ventricles, indicating the formation of heart failure.
About the Authors
D. S. Kulchanovskaya
Saint Petersburg State Chemical and Pharmaceutical University of the Ministry of Health Care of Russia
Russian Federation
Russian Federation
Daria S. Kulchanovskaya
197376, Saint Petersburg, Professora Popova Str., 14, lit. A
A. V. Chernomordova
First Saint Petersburg State Medical University named after Academician I.P. Pavlov of the Ministry of Health Care of Russia
Russian Federation
Russian Federation
Alexandra V. Chernomordova
197022, Saint Petersburg, L’va Tolstogo Str., 6–8
S. V. Okovitiy
Saint Petersburg State Chemical and Pharmaceutical University of the Ministry of Health Care of Russia
Russian Federation
Russian Federation
Sergey V. Okovitiy, Dr. Sci. (Med.), Prof.
197376, Saint Petersburg, Professora Popova Str., 14, lit. A
A. N. Kulikov
First Saint Petersburg State Medical University named after Academician I.P. Pavlov of the Ministry of Health Care of Russia
Russian Federation
Russian Federation
Alexander N. Kulikov, Dr. Sci. (Med.), Prof.
197022, Saint Petersburg, L’va Tolstogo Str., 6–8
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Review
For citations:
Kulchanovskaya D.S., Chernomordova A.V., Okovitiy S.V., Kulikov A.N. Experimental Modeling of Heart Failure in Mice. Journal Biomed. 2024;20(3):84-88. (In Russ.) https://doi.org/10.33647/2074-5982-20-3-84-88
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